Nanocatalytic Innate Immunity Activation by Mitochondrial DNA Oxidative Damage for Tumor-Specific Therapy
The innate immune system performs a key position in defending the human physique from tumors, which, sadly, is essentially counteracted by their immune-suppression perform. Such an immune suppression has been reported to be induced by the immunosuppressive microenvironment, together with the exhausted cytotoxic T lymphocytes (CTLs) and tumor-promoting M2-polarized macrophages. Right here, a novel tumor-immunotherapeutic modality primarily based on the nanocatalytic innate immunity activation by tumor-specific mitochondrial DNA (mtDNA) oxidative harm is proposed.
Intimately, a nanocatalytic medication, Fe2+ -Ru2+ -loaded mesoporous silica nanoparticle named as MSN-Ru2+ /Fe2+ (MRF), is constructed to induce oxidative harm within the mtDNA of tumor cells. Such an oxidative mtDNA is ready to escape from the tumor cells and acts as an immunogenic damage-associated molecular sample to M1-polarize tumor-associated macrophages (TAMs), ensuing within the reactivated immunoresponse of macrophages in opposition to most cancers cells, and the following inflammatory response of innate immunity. Most significantly, the therapy technique primarily based on regulating the innate immune response of TAMs not solely stops the first tumor development, but additionally nearly fully inhibits the expansion of distant tumors within the intervals of remedies.
Activation of NF-κB signaling through cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA frequent deletion
Scar formation on account of corneal wound therapeutic is a number one explanation for blindness. It’s a problem to grasp why scar formation is extra prone to happen within the central a part of the cornea as in comparison with the peripheral half. The aim of this research was to unravel the underlying mechanisms. We utilized RNA-seq to uncover the variations of expression profile in keratocytes within the central/peripheral a part of the cornea. The relative amount of mitochondrial RNA was measured by multiplex qPCR.
The characterization of mitochondrial RNA within the cytoplasm was confirmed by immunofluoresence microscope and biochemical strategy. Gene expression was analyzed by western blot and RT qPCR. We reveal that the prevalence of mitochondrial DNA frequent deletion is bigger in keratocytes from the central cornea as in comparison with these of the peripheral half.
The keratocytes with CD have elevated oxidative stress ranges, which results in the leakage of mitochondrial double-stranded RNA into the cytoplasm. The cytoplasmic mitochondrial double-stranded RNA is sensed by MDA5, which induces NF-κB activation. The NF-κB activation thereafter induces fibrosis-like extracellular matrix expressions and IL-Eight mRNA transcription. These outcomes present a novel clarification of the completely different scientific end result in several areas of the cornea throughout wound therapeutic.
Present and new Subsequent-Era Sequencing approaches to review mitochondrial DNA
Mitochondria harbor a number of copies of a maternally inherited non-nuclear genome; level mutations, deletions, or depletion of the mitochondrial DNA have been related to numerous human ailments. Totally different approaches have been used to research mitochondrial DNA defects: Sanger sequencing, Southern blot, lengthy and quantitative PCR. All these applied sciences are inherently hampered by limitations in pace, throughput, sensitivity, and related prices. Just lately, Subsequent Era Sequencing has been launched on this discipline and all its potential functions nonetheless should be absolutely validated.
Evaluation of mitochondrial DNA from 16 management samples and 33 affected samples, beforehand investigated by conventional strategies, was carried out. Totally different Subsequent Era Sequencing approaches had been examined, utilizing classical library preparation primarily based on PCR amplifications and an modern PCR-free protocol, defining their suitability and utility for: (i) producing full correct mtDNA sequence, (ii) assessing heteroplasmy for single level mutations with excessive accuracy, (iii) detecting break positions and heteroplasmy of single massive deletions. This research confirmed that PCR-based library preparations are applicable for the primary two factors whereas confirmed {that a} new PCR-free technique gave the most effective outcomes for the third goal.
Phylogeography and demographic historical past of Thai Pediculus humanus capitis (Phthiraptera: Pediculidae) revealed by mitochondrial DNA sequences
Pediculus humanus (human louse) is a hematophagous insect that feeds on human blood. It’s distributed worldwide. Understanding phylogeography and population-genetic construction of the human louse will illuminate the evolution of this insect and the dynamics of how resistance alleles may unfold within the panorama. On this work, we used mitochondrial (cox1 and cytb genes) sequences of the human louse to research genetic range, population-genetic construction and demographic historical past of the louse in Thailand.
Human lice in Thailand belonged to mitochondrial clades A and C. Most genetic variation was attributed to intra-region 65.71% inside provinces for clade A and 68.92% for clade C, whereas inter-region stage was 34.40% amongst provinces inside areas for clade A and 20.09% for clade C. Neutrality and different indices urged that louse populations from clades A and C in Thailand have skilled a inhabitants enlargement. However head lice from Khon Kaen Province in clade C demonstrated a major current inhabitants bottleneck or pure selective stress with fixed inhabitants dimension.
Head lice in Thailand confirmed various levels of low to excessive genetic differentiation on the stage of province with many populations being genetically distinct from one another amongst areas and throughout the similar area. Data of the clades current in Thailand and that gene circulation happens between areas will help in creating applicable methods for administration of head lice on the native stage within the nation.
Mitochondrial DNA revealed the validation of Quasipaa robertingeri (Amphibia: Anura: Dicroglossidae) and its inhabitants genetic range
The spiny frog Quasipaa robertingeri is endemic to a slim area of southwest China and its taxonomic validation continues to be controversial. Primarily based on COI gene sequences of 110 people from seven populations of Q. robertingeri and its associated species, we investigated the phylogenetic place and inhabitants genetic construction of the species.
Recombinant Bordetella petrii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1146458-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1215 |
Recombinant Bordetella petrii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1146458-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1295 |
Recombinant Bordetella avium Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1483805-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1350 |
Recombinant Bordetella avium Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1483805-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Bordetella avium Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1483805-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Bordetella avium Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1483805-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1220 |
Recombinant Bordetella avium Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1483805-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1300 |
Recombinant Bordetella pertussis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1430668-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Bordetella pertussis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1430668-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1030 |
Recombinant Bordetella pertussis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1430668-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1130 |
Recombinant Bordetella pertussis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1430668-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1200 |
Recombinant Bordetella pertussis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1430668-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1285 |
Recombinant Bordetella bronchiseptica Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1398709-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1345 |
Recombinant Bordetella bronchiseptica Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1398709-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Bordetella bronchiseptica Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1398709-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1140 |
Recombinant Bordetella bronchiseptica Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1398709-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1220 |
Recombinant Bordetella bronchiseptica Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1398709-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1300 |
Recombinant Chromosomal replication initiator protein DnaA (dnaA), partial |
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| MBS1116065-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Chromosomal replication initiator protein DnaA (dnaA), partial |
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| MBS1083125-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Borrelia garinii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1347181-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1350 |
Recombinant Borrelia garinii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1347181-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Borrelia garinii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1347181-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia garinii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1347181-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1225 |
Recombinant Borrelia garinii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1347181-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Borrelia duttonii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1026061-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1350 |
Recombinant Borrelia duttonii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1026061-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Borrelia duttonii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1026061-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia duttonii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1026061-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1225 |
Recombinant Borrelia duttonii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1026061-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Borrelia hermsii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1065572-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1350 |
Recombinant Borrelia hermsii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1065572-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Borrelia hermsii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1065572-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia hermsii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1065572-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1225 |
Recombinant Borrelia hermsii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1065572-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Borrelia afzelii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1463920-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Borrelia afzelii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1463920-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1350 |
Recombinant Borrelia afzelii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1463920-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1050 |
Recombinant Borrelia afzelii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1463920-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia afzelii Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1463920-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1225 |
Recombinant Nostoc sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1299838-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1325 |
Recombinant Nostoc sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1299838-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1015 |
Recombinant Nostoc sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1299838-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Nostoc sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1299838-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Nostoc sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1299838-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1275 |
Recombinant Borrelia recurrentis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1105112-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1350 |
Recombinant Borrelia recurrentis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1105112-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Borrelia recurrentis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1105112-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia recurrentis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1105112-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1225 |
Recombinant Borrelia recurrentis Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1105112-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1193511-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1355 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1193511-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1050 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1193511-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1193511-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1225 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1193511-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Borrelia turicatae Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1134609-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1350 |
Recombinant Borrelia turicatae Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1134609-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Borrelia turicatae Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1134609-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia turicatae Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1134609-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1225 |
Recombinant Borrelia turicatae Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1134609-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1229773-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1355 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1229773-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1050 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1229773-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1229773-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1230 |
Recombinant Borrelia burgdorferi Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1229773-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1305 |
Recombinant Vibrio parahaemolyticus Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1380146-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Vibrio parahaemolyticus Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1380146-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1030 |
Recombinant Vibrio parahaemolyticus Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1380146-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1130 |
Recombinant Vibrio parahaemolyticus Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1380146-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1200 |
Recombinant Vibrio parahaemolyticus Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1380146-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1285 |
Recombinant Azoarcus sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1227481-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1345 |
Recombinant Azoarcus sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1227481-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1045 |
Recombinant Azoarcus sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1227481-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1140 |
Recombinant Azoarcus sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1227481-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1220 |
Recombinant Azoarcus sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1227481-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1300 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1169423-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1169423-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1025 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1169423-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1125 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1169423-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1195 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1169423-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1285 |
Recombinant Salmonella paratyphi B Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1122185-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Salmonella paratyphi B Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1122185-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1025 |
Recombinant Salmonella paratyphi B Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1122185-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1125 |
Recombinant Salmonella paratyphi B Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1122185-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1195 |
Recombinant Salmonella paratyphi B Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1122185-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1285 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1386256-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1386256-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1025 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1386256-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1125 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1386256-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1195 |
Recombinant Salmonella paratyphi A Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1386256-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1285 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1238485-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1238485-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1020 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1238485-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1238485-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1238485-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1275 |
Recombinant Jannaschia sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1342067-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1340 |
Recombinant Jannaschia sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1342067-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1035 |
Recombinant Jannaschia sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1342067-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1135 |
Recombinant Jannaschia sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1342067-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1210 |
Recombinant Jannaschia sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1342067-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1295 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1204809-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1320 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1204809-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1010 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1204809-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1115 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1204809-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1180 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1204809-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1270 |
Recombinant Thermotoga sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1153472-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1310 |
Recombinant Thermotoga sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1153472-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 995 |
Recombinant Thermotoga sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1153472-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1100 |
Recombinant Thermotoga sp. Chromosomal replication initiator protein DnaA (dnaA) |
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| MBS1153472-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1160 |
Recombinant Thermotoga sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1153472-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1255 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1307851-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1307851-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1020 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1307851-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1307851-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1307851-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1275 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1287709-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1287709-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1020 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1287709-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1287709-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1287709-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1275 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1252455-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1325 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1252455-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1015 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1252455-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1115 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1252455-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1180 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1252455-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1270 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1254198-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1320 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1254198-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1010 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1254198-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1115 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1254198-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1180 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1254198-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1270 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1109874-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1315 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1109874-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1000 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1109874-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1105 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1109874-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1170 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1109874-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1260 |
Recombinant Wolbachia sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1008657-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1105 |
Recombinant Wolbachia sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1008657-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 700 |
Recombinant Wolbachia sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1008657-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 860 |
Recombinant Wolbachia sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1008657-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 820 |
Recombinant Wolbachia sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1008657-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1005 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1076916-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1076916-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1020 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1076916-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1125 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1076916-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Shewanella sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1076916-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1280 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1080016-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1080016-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1020 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1080016-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1080016-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Cyanothece sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1080016-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1275 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1088073-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1330 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1088073-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1020 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1088073-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1120 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1088073-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1190 |
Recombinant Geobacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1088073-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1275 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1226199-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1315 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1226199-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1000 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1226199-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1110 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1226199-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1170 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1226199-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1260 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1218215-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1315 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1218215-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1000 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1218215-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1110 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1218215-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1170 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1218215-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1260 |
Recombinant Vibrio fischeri Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1329444-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Vibrio fischeri Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1329444-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1030 |
Recombinant Vibrio fischeri Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1329444-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1130 |
Recombinant Vibrio fischeri Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1329444-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1200 |
Recombinant Vibrio fischeri Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1329444-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1285 |
Recombinant Silicibacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1341265-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Silicibacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1341265-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1030 |
Recombinant Silicibacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1341265-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1130 |
Recombinant Silicibacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1341265-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1205 |
Recombinant Silicibacter sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1341265-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1290 |
Recombinant Geobacillus sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1193234-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1320 |
Recombinant Geobacillus sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1193234-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1005 |
Recombinant Geobacillus sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1193234-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1110 |
Recombinant Geobacillus sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1193234-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1175 |
Recombinant Geobacillus sp. Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1193234-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1265 |
Recombinant Oenococcus oeni Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1206743-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1320 |
Recombinant Oenococcus oeni Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1206743-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1005 |
Recombinant Oenococcus oeni Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1206743-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1110 |
Recombinant Oenococcus oeni Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1206743-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1175 |
Recombinant Oenococcus oeni Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1206743-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1265 |
Recombinant Rhizobium loti Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1367138-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1355 |
Recombinant Rhizobium loti Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1367138-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1055 |
Recombinant Rhizobium loti Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1367138-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1115 |
Recombinant Rhizobium loti Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1367138-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1230 |
Recombinant Rhizobium loti Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1367138-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1310 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1369093-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1315 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1369093-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1000 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1369093-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1110 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1369093-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1170 |
Recombinant Bacillus cereus Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1369093-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1260 |
Recombinant Vibrio harveyi Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1256576-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Vibrio harveyi Chromosomal replication initiator protein DnaA (dnaA) |
|||
| MBS1256576-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1030 |
Phylogenetic analyses indicated that Q. robertingeri was deeply genetically separated from its carefully associated species Q. boulengeri, indicating the validation of the species. All samples of Q. robertingeri had been clustered into two divergent lineages. Haplotype community, AMOVA, and genetic distance estimations additionally supported the separations of the 2 teams. Neutrality exams indicated that one lineage has been doubtless independently skilled a current inhabitants enlargement, resulting in a secondary contact space between the 2 lineages.
