H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
- Ellie
- 0
Most cancers is likely one of the ailments that threatens human well being and is a number one reason behind mortality worldwide. Excessive ranges of reactive oxygen species (ROS) have been noticed in most cancers tissues in contrast with regular tissues in vivo, and it’s not but recognized how this influences chemotherapeutic drug motion. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer utilized in photodynamic remedy (PDT) and a telomerase inhibitor used within the remedy of telomerase-positive most cancers.
Right here, we investigated the anticancer exercise of TMPyP4 in A549 and PANC cells cultured in H2O2. The outcomes confirmed that in comparison with TMPyP4 alone, the mix of TMPyP4 and H2O2 exhibited sensitization results on cell viability and colony formation inhibition and apoptosis in A549 and PANC cells, however had no impact in human regular MIHA cells.
Mechanistically, the mix of TMPyP4 and H2O2 prompts excessive ROS and mitochondrial membrane potential in A549 and PANC cells, leading to intense DNA harm and DNA harm responses. Consequently, in comparison with TMPyP4 alone, TMPyP4 and H2O2 mixed remedy upregulates the expression of BAX, cleaved caspase 3, and p-JNK and downregulates the expression of Bcl-2 in A549 and PANC cells. Taken collectively, these knowledge prompt that H2O2 enhanced the anticancer exercise of TMPyP4-mediated ROS-dependent DNA harm and associated apoptotic protein regulation, revealing that the excessive ROS tumor microenvironment performs an vital position in chemotherapeutic drug motion.
Survival of an launched ectomycorrhizal Laccaria bicolor pressure in a European forest plantation monitored by mitochondrial ribosomal DNA evaluation
Mitochondrial and nuclear genes have totally different inheritance, thus research of fungal populations ought to use each mitochondrial and nuclear markers. Utilizing nuclear markers, the S238N pressure of the ectomycorrhizal basidiomycete Laccaria bicolor ((Maire) Orton) has been beforehand proven to persist for a minimum of 10 yr after outplanting in a plantation of Douglas fir (Pseudotsuga menziesii (Mir.) Franco) inoculated with this pressure. Within the current research, we’ve got sampled 539 sporophores of Laccaria spp. from this plantation, a few of which had the S238N nuclear genotype, to review mitochondrial DNA polymorphism and persistence of the inoculated S238N mitochondrial genome.
Size polymorphism in fragments of the big subunit of mitochondrial ribosomal DNA (LrDNA) allowed distinction of the haplotypes current within the plantation on the species stage. As well as, heteroduplex evaluation and sequencing revealed intraspecific polymorphism of LrDNA among the many L. bicolor sporophores and enabled particular identification of S238N LrDNA. This haplotype was solely retained in sporophores carrying the S238N nuclear genome, confirming the survival of this launched pressure in a pure inhabitants.
Bioallethrin enhances technology of ROS, damages DNA, impairs the redox system and causes mitochondrial dysfunction in human lymphocytes
Bioallethrin is an artificial pesticide that’s extensively used to manage insect pests. The broad use of bioallethrin has resulted in inevitable human publicity. On this research we report the impact of various concentrations of bioallethrin (10 to 200 µM, 2 h at 37 °C) on human lymphocytes underneath in vitro circumstances. Bioallethrin remedy resulted in lack of cell viability (> 30% at 200 µM bioallethrin). Oxidative stress markers like lipid peroxidation and protein oxidation have been considerably elevated accompanied by decrease ratio of decreased to oxidized glutathione.
Enhanced ROS technology was noticed by way of fluorescence spectroscopy and microscopy. Bioallethrin-induced oxidative stress additionally compromised the antioxidant defence because it decreased antioxidant capability of cells and inhibited main antioxidant enzymes. Biomolecular modifications and systemic toxicity by bioallethrin resulted in plasma membrane harm with mitochondrial depolarization.
Comet assay confirmed nuclear DNA fragmentation and strand scission with vital enhance in tail size and olive tail second. Apoptosis and necrosis of cells was confirmed by way of acridine orange/ethidium bromide twin staining and visualization underneath fluorescence microscope. Thus, bioallethrin causes oxidative harm and compromises the antioxidant system resulting in DNA harm, mobile and organelle toxicity, leading to apoptosis and necrosis of human lymphocytes.
Unearthing Neanderthal inhabitants historical past utilizing nuclear and mitochondrial DNA from cave sediments
Bones and enamel are vital sources of Pleistocene hominin DNA, however are hardly ever recovered at archaeological websites. Mitochondrial DNA has been retrieved from cave sediments, however offers restricted worth for learning inhabitants relationships. We due to this fact developed strategies for the enrichment and evaluation of nuclear DNA from sediments, and utilized them to cave deposits in western Europe and southern Siberia dated to between roughly 200,000 and 50,000 years in the past.
We detect a inhabitants substitute in northern Spain roughly 100,000 years in the past, accompanied by a turnover of mitochondrial DNA. We additionally establish two radiation occasions in Neanderthal historical past through the early a part of the Late Pleistocene. Our work lays the bottom for learning the inhabitants historical past of historical hominins from hint quantities of nuclear DNA in sediments.
Mitochondrial DNA mutations contribute to excessive altitude pulmonary edema by way of elevated oxidative stress and metabolic reprogramming throughout hypobaric hypoxia
Excessive altitude pulmonary edema (HAPE) is skilled by non-acclimatized sea stage people on publicity to excessive altitude hypoxic circumstances. Obtainable proof means that genetic elements and perturbed mitochondrial redox standing could play an vital position in HAPE pathophysiology. Nevertheless, the exact mechanism has not been absolutely understood.
Within the current research, sequencing of mitochondrial DNA (mtDNA) from HAPE topics and acclimatized controls was carried out to establish pathogenic mutations and to find out their position in HAPE. Hypobaric hypoxia induced oxidative stress and metabolic alterations have been additionally assessed in HAPE topics. mtDNA copy quantity, mitochondrial oxidative phosphorylation (mtOXPHOS) exercise, mitochondrial biogenesis have been measured to find out mitochondrial features.
The information revealed that the mutations in Advanced I genes impacts the secondary construction of protein in HAPE topics. Additional, elevated oxidative stress throughout hypobaric hypoxia, decreased mitochondrial biogenesis and mtOXPHOS exercise induced metabolic reprogramming which may contribute to mitochondrial dysfunctions in HAPE people.
Recombinant Taq Dna Polymerase |
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27079806 | Scientific Laboratory Supplies | EACH | EUR 607.62 |
Taq DNA Polymerase (Recombinant) |
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22060707-1 | Glycomatrix | 1,000 Unit(s) | EUR 137.27 |
Taq DNA Polymerase (Recombinant) |
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22060707-2 | Glycomatrix | 1500 Unit(s) | EUR 182.1 |
Taq DNA Polymerase (Recombinant) |
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22060707-3 | Glycomatrix | 5000 Unit(s) | EUR 465.77 |
Taq DNA Polymerase (Recombinant) |
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22060707-4 | Glycomatrix | 10 KU | EUR 840.96 |
Recombinant Pfu DNA Polymerase |
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7-03322 | CHI Scientific | 100U | Ask for price |
Recombinant Pfu DNA Polymerase |
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7-03323 | CHI Scientific | 500U | Ask for price |
Recombinant Pfu DNA Polymerase |
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7-03324 | CHI Scientific | 2500U | Ask for price |
Recombinant Taq DNA Polymerase |
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7-03634 | CHI Scientific | 1,000U | Ask for price |
Recombinant Taq DNA Polymerase |
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7-03635 | CHI Scientific | 3,000U | Ask for price |
Recombinant Taq DNA Polymerase |
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7-03636 | CHI Scientific | 10,000U | Ask for price |
Pfu DNA Polymerase (Recombinant) |
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abx074017-100U | Abbexa | 100 U | EUR 393.6 |
Pfu DNA Polymerase (Recombinant) |
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abx074017-2500U | Abbexa | 2500 U | EUR 1528.8 |
Pfu DNA Polymerase (Recombinant) |
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abx074017-500U | Abbexa | 500 U | EUR 526.8 |
Taq DNA Polymerase (Recombinant) |
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abx073521-10000U | Abbexa | 10000 U | EUR 710.4 |
Taq DNA Polymerase (Recombinant) |
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abx073521-1000U | Abbexa | 1000 U | EUR 276 |
Taq DNA Polymerase (Recombinant) |
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abx073521-3000U | Abbexa | 3000 U | EUR 393.6 |
Taq DNA Polymerase Recombinant |
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rAP-1062 | Angio Proteomie | Inquiry | Ask for price |
DNA Topoisomerase-I (Recombinant) |
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20-abx073616 | Abbexa |
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Recombinant (E.Coli) T4 DNA Ligase |
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RP-374 | Alpha Diagnostics | 20 KU | EUR 196.8 |
Recombinant human DNA-directed DNA/RNA polymerase mu |
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P2815 | FN Test | 100ug | Ask for price |
Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu |
Recombinant Taq Dna Polymerase - EACH |
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27079804 | Scientific Laboratory Supplies | EACH | EUR 132.3 |
Recombinant Taq Plus DNA Polymerase |
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7-03631 | CHI Scientific | 250U | Ask for price |
Recombinant Taq Plus DNA Polymerase |
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7-03632 | CHI Scientific | 750U | Ask for price |
Recombinant Taq Plus DNA Polymerase |
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7-03633 | CHI Scientific | 2,500U | Ask for price |
Taq Plus DNA Polymerase (Recombinant) |
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abx073522-2500U | Abbexa | 2.500 U | EUR 710.4 |
Taq Plus DNA Polymerase (Recombinant) |
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abx073522-250U | Abbexa | 250 U | EUR 276 |
Taq Plus DNA Polymerase (Recombinant) |
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abx073522-750U | Abbexa | 750 U | EUR 393.6 |
Recombinant (E.Coli) Taq DNA Polymerase |
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RP-394 | Alpha Diagnostics | 1000 IU | EUR 196.8 |
Taq Plus DNA Polymerase Recombinant |
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rAP-1063 | Angio Proteomie | Inquiry | Ask for price |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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CSB-YP889065HU | Cusabio | 6730 mg | Ask for price |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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CSB-EP889065HU | Cusabio | 4769 mg | Ask for price |
Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) |
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AP77539 | SAB | each | Ask for price |
Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) |
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AP77602 | SAB | 1mg | EUR 2826 |
Recombinant Human DNA-directed DNA/RNA polymerase mu(POLM) |
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AP77996 | SAB | each | Ask for price |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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CSB-BP889065HU | Cusabio | 277 mg | Ask for price |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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RPC23722-100ug | Biomatik Corporation | 100ug | EUR 572 |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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RPC23722-1mg | Biomatik Corporation | 1mg | EUR 2884.7 |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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RPC23722-20ug | Biomatik Corporation | 20ug | EUR 353.4 |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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RPC20704-100ug | Biomatik Corporation | 100ug | EUR 1463 |
Recombinant Human DNA-directed DNA/RNA polymerase mu (POLM) |
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RPC20704-20ug | Biomatik Corporation | 20ug | EUR 580.8 |
Recombinant Uracil DNA Glycosylase (UNG) |
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RPU51901-100ug | Biomatik Corporation | 100ug | EUR 504.9 |
Recombinant Uracil DNA Glycosylase (UNG) |
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RPU51901-1mg | Biomatik Corporation | 1mg | EUR 2238.6 |
Recombinant Uracil DNA Glycosylase (UNG) |
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RPU51901-50ug | Biomatik Corporation | 50ug | EUR 405.9 |
Recombinant Uracil DNA Glycosylase (UNG) |
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RPG917Hu01 | Cloud-Clone | 10ug | EUR 164 |
Recombinant Uracil DNA Glycosylase (UNG) |
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4-RPG917Hu01 | Cloud-Clone |
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Description: Recombinant Human Uracil DNA Glycosylase expressed in: E.coli |
Human DNA Topoisomerase-I (Recombinant) |
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22060306-1 | Glycomatrix | 5 µg | EUR 146.42 |
Recombinant Human DNA Topoisomerase-I |
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7-03658 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Topoisomerase-I |
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7-03659 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Topoisomerase-I |
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7-03660 | CHI Scientific | 1mg | Ask for price |
DNA Polymerase beta Recombinant Protein |
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91-139 | ProSci | 0.05 mg | EUR 651.3 |
Description: Human DNA polymerase beta is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. The activity cannot be affected by Aphidicolin, which is an inhibitor of DNA polymerase beta . |
Uracil DNA Glycosylase E.Coli Recombinant |
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rAP-1141 | Angio Proteomie | Inquiry | Ask for price |
DNA Topoisomerase-I Human Recombinant |
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rAP-1220 | Angio Proteomie | Inquiry | Ask for price |
E.Coli Adenine DNA Glycosylase (Recombinant) |
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20-abx074009 | Abbexa |
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Polymerase (DNA directed), beta (Recombinant) |
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20-abx073237 | Abbexa |
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Adenine DNA Glycosylase E.Coli Recombinant |
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rAP-1139 | Angio Proteomie | Inquiry | Ask for price |
Recombinant Human DNA ligase 1 (LIG1) |
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CSB-EP012930HU | Cusabio | 1617 mg | Ask for price |
Recombinant Human DNA ligase 1(LIG1) |
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AP70504 | SAB | 1mg | EUR 1978 |
DNA-PKcs recombinant monoclonal antibody |
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A5876 | Bimake | 100ul X 3 | EUR 714 |
Description: A recombinant monoclonal antibody from rabbit against human DNA-PKcs for WB, IHC,ELISA |
8-Oxoguanine DNA Glycosylase (Recombinant) |
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20-abx073274 | Abbexa |
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Polymerase (DNA directed), lambda (Recombinant) |
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20-abx073724 | Abbexa |
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Recombinant DNA Methyltransferase 1 (DNMT1) |
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RPJ244Hu01 | Cloud-Clone | 10ug | EUR 172 |
Recombinant DNA Methyltransferase 1 (DNMT1) |
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4-RPJ244Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Methyltransferase 1 expressed in: E.coli |
Recombinant DNA Methyltransferase 1 (DNMT1) |
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RPJ244Mu01 | Cloud-Clone | 10ug | EUR 140 |
Recombinant DNA Methyltransferase 1 (DNMT1) |
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RPJ244Mu02 | Cloud-Clone | 10ug | EUR 140 |
Recombinant DNA Methyltransferase 1 (DNMT1) |
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RPU41218-100ug | Biomatik Corporation | 100ug | EUR 530.2 |
Recombinant DNA Methyltransferase 1 (DNMT1) |
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RPU41218-1mg | Biomatik Corporation | 1mg | EUR 2347.8 |
Recombinant DNA Methyltransferase 1 (DNMT1) |
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RPU41218-50ug | Biomatik Corporation | 50ug | EUR 425.7 |
Recombinant DNA Methyltransferase 3A (DNMT3A) |
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RPJ245Hu01 | Cloud-Clone | 10ug | EUR 140 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPJ246Hu01 | Cloud-Clone | 10ug | EUR 140 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPJ246Mu01 | Cloud-Clone | 10ug | EUR 172 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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4-RPJ246Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Methyltransferase 3B expressed in: E.coli |
Recombinant DNA Methyltransferase 3A (DNMT3A) |
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RPU59419-100ug | Biomatik Corporation | 100ug | EUR 470.4 |
Recombinant DNA Methyltransferase 3A (DNMT3A) |
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RPU59419-1mg | Biomatik Corporation | 1mg | EUR 2047.5 |
Recombinant DNA Methyltransferase 3A (DNMT3A) |
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RPU59419-50ug | Biomatik Corporation | 50ug | EUR 336 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU57666-100ug | Biomatik Corporation | 100ug | EUR 470.4 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU57666-1mg | Biomatik Corporation | 1mg | EUR 2184 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU57666-50ug | Biomatik Corporation | 50ug | EUR 385 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU57667-100ug | Biomatik Corporation | 100ug | EUR 470.4 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU57667-1mg | Biomatik Corporation | 1mg | EUR 2184 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU57667-50ug | Biomatik Corporation | 50ug | EUR 385 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU52741-100ug | Biomatik Corporation | 100ug | EUR 530.2 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU52741-1mg | Biomatik Corporation | 1mg | EUR 2347.8 |
Recombinant DNA Methyltransferase 3B (DNMT3B) |
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RPU52741-50ug | Biomatik Corporation | 50ug | EUR 425.7 |
DNA Topoisomerase-I 70 kDa (Recombinant) |
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20-abx073615 | Abbexa |
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Recombinant (E.Coli) Taq Plus DNA Polymerase |
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RP-395 | Alpha Diagnostics | 250 U | EUR 196.8 |
Recombinant DNA-binding protein fis (fis) |
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CSB-YP358868SWW | Cusabio | 10100 mg | Ask for price |
Recombinant human DNA repair protein REV1 |
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P2230 | FN Test | 100ug | Ask for price |
Description: Recombinant protein for human DNA repair protein REV1 |
TAR DNA Binding Protein Human Recombinant |
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rAP-4928 | Angio Proteomie | Inquiry | Ask for price |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU41219-100ug | Biomatik Corporation | 100ug | EUR 665.5 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU41219-1mg | Biomatik Corporation | 1mg | EUR 2948.4 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU41219-50ug | Biomatik Corporation | 50ug | EUR 534.6 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU41220-100ug | Biomatik Corporation | 100ug | EUR 665.5 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU41220-1mg | Biomatik Corporation | 1mg | EUR 2948.4 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU41220-50ug | Biomatik Corporation | 50ug | EUR 534.6 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU54001-100ug | Biomatik Corporation | 100ug | EUR 566.5 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU54001-1mg | Biomatik Corporation | 1mg | EUR 2511.6 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU54001-50ug | Biomatik Corporation | 50ug | EUR 455.4 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU56270-100ug | Biomatik Corporation | 100ug | EUR 573.1 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU56270-1mg | Biomatik Corporation | 1mg | EUR 2538.9 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPU56270-50ug | Biomatik Corporation | 50ug | EUR 460.9 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPK111Hu01 | Cloud-Clone | 10ug | EUR 216 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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4-RPK111Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPK111Hu02 | Cloud-Clone | 10ug | EUR 216 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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4-RPK111Hu02 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPK111Mu01 | Cloud-Clone | 10ug | EUR 184 |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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4-RPK111Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Repair Protein RAD50 expressed in: E.coli |
Recombinant DNA Repair Protein RAD50 (RAD50) |
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RPK111Ra01 | Cloud-Clone | 10ug | EUR 188 |
OPPA00808-20KIU - T4 DNA Ligase Recombinant |
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OPPA00808-20KIU | Aviva Systems Biology | 20,000IU | EUR 81 |
Recombinant Escherichia coli DNA ligase (ligA) |
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CSB-EP322745ENV | Cusabio | 2850 mg | Ask for price |
Recombinant Escherichia coli DNA ligase(ligA) |
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AP71013 | SAB | 1mg | EUR 2826 |
Recombinant human DNA-binding protein RFX2 |
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P2855 | FN Test | 100ug | Ask for price |
Description: Recombinant protein for human DNA-binding protein RFX2 |
Recombinant Human DNA Topoisomerase-I 70kDa |
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7-03661 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Topoisomerase-I 70kDa |
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7-03662 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Topoisomerase-I 70kDa |
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7-03663 | CHI Scientific | 1mg | Ask for price |
DNA Ligase IV recombinant monoclonal antibody |
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A5820 | Bimake | 100ul X 3 | EUR 714 |
Description: A recombinant monoclonal antibody from rabbit against human DNA Ligase IV for WB, IHC, IF,ELISA |
Recombinant DNA expression in Pichia pastoris |
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HESAP-1002-10G | Cyagen | 10G | EUR 2250 |
DNA Topoisomerase-I 70kDa Recombinant Human |
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rAP-1208 | Angio Proteomie | Inquiry | Ask for price |
Recombinant human DNA-binding protein RFXANK |
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P2771 | FN Test | 100ug | Ask for price |
Description: Recombinant protein for human DNA-binding protein RFXANK |
Polymerase (DNA directed), Beta Human Recombinant |
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rAP-1060 | Angio Proteomie | Inquiry | Ask for price |
Recombinant Human DNA nucleotidylexotransferase (DNTT) |
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CSB-EP007088HU | Cusabio | 1036 mg | Ask for price |
Recombinant Human DNA nucleotidylexotransferase(DNTT) |
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AP70241 | SAB | 1mg | EUR 1978 |
Recombinant Human DNA nucleotidylexotransferase (DNTT) |
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RPC21219-100ug | Biomatik Corporation | 100ug | EUR 460.9 |
Recombinant Human DNA nucleotidylexotransferase (DNTT) |
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RPC21219-1mg | Biomatik Corporation | 1mg | EUR 2237.8 |
Recombinant Human DNA nucleotidylexotransferase (DNTT) |
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RPC21219-20ug | Biomatik Corporation | 20ug | EUR 258.7 |
Recombinant Human 8-Oxoguanine DNA Glycosylase |
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7-03277 | CHI Scientific | 5µg | Ask for price |
Recombinant Human 8-Oxoguanine DNA Glycosylase |
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7-03278 | CHI Scientific | 20µg | Ask for price |
Recombinant Human 8-Oxoguanine DNA Glycosylase |
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7-03279 | CHI Scientific | 1mg | Ask for price |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPH625Hu01 | Cloud-Clone | 10ug | EUR 169 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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4-RPH625Hu01 | Cloud-Clone |
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Description: Recombinant Human N-Methylpurine DNA Glycosylase expressed in: E.coli |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPH625Mu01 | Cloud-Clone | 10ug | EUR 176 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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4-RPH625Mu01 | Cloud-Clone |
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Description: Recombinant Mouse N-Methylpurine DNA Glycosylase expressed in: E.coli |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPH625Ra01 | Cloud-Clone | 10ug | EUR 188 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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4-RPH625Ra01 | Cloud-Clone |
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Description: Recombinant Rat N-Methylpurine DNA Glycosylase expressed in: E.coli |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43074-100ug | Biomatik Corporation | 100ug | EUR 520.3 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43074-1mg | Biomatik Corporation | 1mg | EUR 2303.6 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43074-50ug | Biomatik Corporation | 50ug | EUR 418 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43075-100ug | Biomatik Corporation | 100ug | EUR 542.3 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43075-1mg | Biomatik Corporation | 1mg | EUR 2402.4 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43075-50ug | Biomatik Corporation | 50ug | EUR 435.6 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43076-100ug | Biomatik Corporation | 100ug | EUR 578.6 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43076-1mg | Biomatik Corporation | 1mg | EUR 2566.2 |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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RPU43076-50ug | Biomatik Corporation | 50ug | EUR 465.3 |
8-Oxoguanine DNA Glycosylase Mouse Recombinant |
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rAP-1132 | Angio Proteomie | Inquiry | Ask for price |
8-Oxoguanine DNA Glycosylase Human Recombinant |
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rAP-1134 | Angio Proteomie | Inquiry | Ask for price |
Polymerase (DNA directed), Lambda Human Recombinant |
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rAP-1590 | Angio Proteomie | Inquiry | Ask for price |
Recombinant DNA-binding protein H-NS(hns) |
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AP74001 | SAB | 1mg | EUR 2826 |
Recombinant Human DNA Polymerase β (C-6His) |
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AP74892 | SAB | 1mg | EUR 3209 |
Recombinant Human DNA Polymerase β (C-6His) |
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C159-10ug | Novoprotein | 10ug | EUR 187.2 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
Recombinant Human DNA Polymerase β (C-6His) |
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C159-1mg | Novoprotein | 1mg | EUR 2739.6 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
Recombinant Human DNA Polymerase β (C-6His) |
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C159-500ug | Novoprotein | 500ug | EUR 1935.6 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
Recombinant Human DNA Polymerase β (C-6His) |
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C159-50ug | Novoprotein | 50ug | EUR 442.8 |
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPU54179-100ug | Biomatik Corporation | 100ug | EUR 578.6 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPU54179-1mg | Biomatik Corporation | 1mg | EUR 2566.2 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPU54179-50ug | Biomatik Corporation | 50ug | EUR 465.3 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPU54517-100ug | Biomatik Corporation | 100ug | EUR 603.9 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPU54517-1mg | Biomatik Corporation | 1mg | EUR 2675.4 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPU54517-50ug | Biomatik Corporation | 50ug | EUR 485.1 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPB269Hu01 | Cloud-Clone | 10ug | EUR 188 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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4-RPB269Hu01 | Cloud-Clone |
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Description: Recombinant Human ATP Dependent DNA ligase I expressed in: E.coli |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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RPB269Ra01 | Cloud-Clone | 10ug | EUR 196 |
Recombinant ATP Dependent DNA ligase I (LIG1) |
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4-RPB269Ra01 | Cloud-Clone |
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Description: Recombinant Rat ATP Dependent DNA ligase I expressed in: E.coli |
Recombinant Single-stranded DNA Binding Protein |
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AP60509 | SAB | 500ug | EUR 183 |
Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) |
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RPC785Hu01 | Cloud-Clone | 10ug | EUR 140 |
Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) |
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RPC785Mu01 | Cloud-Clone | 10ug | EUR 132 |
Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) |
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4-RPC785Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli |
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Haplogroup evaluation means that mtDNA haplogroup H2a2a1 has potential contribution within the pathobiology of HAPE in lowlanders. This research suggests contribution of altered mitochondrial features in HAPE susceptibility.
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