• June 23, 2021
H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage

H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage

Most cancers is likely one of the ailments that threatens human well being and is a number one reason behind mortality worldwide. Excessive ranges of reactive oxygen species (ROS) have been noticed in most cancers tissues in contrast with regular tissues in vivo, and it’s not but recognized how this influences chemotherapeutic drug motion. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer utilized in photodynamic remedy (PDT) and a telomerase inhibitor used within the remedy of telomerase-positive most cancers.
Right here, we investigated the anticancer exercise of TMPyP4 in A549 and PANC cells cultured in H2O2. The outcomes confirmed that in comparison with TMPyP4 alone, the mix of TMPyP4 and H2O2 exhibited sensitization results on cell viability and colony formation inhibition and apoptosis in A549 and PANC cells, however had no impact in human regular MIHA cells.
Mechanistically, the mix of TMPyP4 and H2O2 prompts excessive ROS and mitochondrial membrane potential in A549 and PANC cells, leading to intense DNA harm and DNA harm responses. Consequently, in comparison with TMPyP4 alone, TMPyP4 and H2O2 mixed remedy upregulates the expression of BAX, cleaved caspase 3, and p-JNK and downregulates the expression of Bcl-2 in A549 and PANC cells. Taken collectively, these knowledge prompt that H2O2 enhanced the anticancer exercise of TMPyP4-mediated ROS-dependent DNA harm and associated apoptotic protein regulation, revealing that the excessive ROS tumor microenvironment performs an vital position in chemotherapeutic drug motion.

Survival of an launched ectomycorrhizal Laccaria bicolor pressure in a European forest plantation monitored by mitochondrial ribosomal DNA evaluation

Mitochondrial and nuclear genes have totally different inheritance, thus research of fungal populations ought to use each mitochondrial and nuclear markers. Utilizing nuclear markers, the S238N pressure of the ectomycorrhizal basidiomycete Laccaria bicolor ((Maire) Orton) has been beforehand proven to persist for a minimum of 10 yr after outplanting in a plantation of Douglas fir (Pseudotsuga menziesii (Mir.) Franco) inoculated with this pressure. Within the current research, we’ve got sampled 539 sporophores of Laccaria spp. from this plantation, a few of which had the S238N nuclear genotype, to review mitochondrial DNA polymorphism and persistence of the inoculated S238N mitochondrial genome.
Size polymorphism in fragments of the big subunit of mitochondrial ribosomal DNA (LrDNA) allowed distinction of the haplotypes current within the plantation on the species stage. As well as, heteroduplex evaluation and sequencing revealed intraspecific polymorphism of LrDNA among the many L. bicolor sporophores and enabled particular identification of S238N LrDNA. This haplotype was solely retained in sporophores carrying the S238N nuclear genome, confirming the survival of this launched pressure in a pure inhabitants.

Bioallethrin enhances technology of ROS, damages DNA, impairs the redox system and causes mitochondrial dysfunction in human lymphocytes

Bioallethrin is an artificial pesticide that’s extensively used to manage insect pests. The broad use of bioallethrin has resulted in inevitable human publicity. On this research we report the impact of various concentrations of bioallethrin (10 to 200 µM, 2 h at 37 °C) on human lymphocytes underneath in vitro circumstances. Bioallethrin remedy resulted in lack of cell viability (> 30% at 200 µM bioallethrin). Oxidative stress markers like lipid peroxidation and protein oxidation have been considerably elevated accompanied by decrease ratio of decreased to oxidized glutathione.
H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
Enhanced ROS technology was noticed by way of fluorescence spectroscopy and microscopy. Bioallethrin-induced oxidative stress additionally compromised the antioxidant defence because it decreased antioxidant capability of cells and inhibited main antioxidant enzymes. Biomolecular modifications and systemic toxicity by bioallethrin resulted in plasma membrane harm with mitochondrial depolarization.
Comet assay confirmed nuclear DNA fragmentation and strand scission with vital enhance in tail size and olive tail second. Apoptosis and necrosis of cells was confirmed by way of acridine orange/ethidium bromide twin staining and visualization underneath fluorescence microscope. Thus, bioallethrin causes oxidative harm and compromises the antioxidant system resulting in DNA harm, mobile and organelle toxicity, leading to apoptosis and necrosis of human lymphocytes.

Unearthing Neanderthal inhabitants historical past utilizing nuclear and mitochondrial DNA from cave sediments

Bones and enamel are vital sources of Pleistocene hominin DNA, however are hardly ever recovered at archaeological websites. Mitochondrial DNA has been retrieved from cave sediments, however offers restricted worth for learning inhabitants relationships. We due to this fact developed strategies for the enrichment and evaluation of nuclear DNA from sediments, and utilized them to cave deposits in western Europe and southern Siberia dated to between roughly 200,000 and 50,000 years in the past.
We detect a inhabitants substitute in northern Spain roughly 100,000 years in the past, accompanied by a turnover of mitochondrial DNA. We additionally establish two radiation occasions in Neanderthal historical past through the early a part of the Late Pleistocene. Our work lays the bottom for learning the inhabitants historical past of historical hominins from hint quantities of nuclear DNA in sediments.

Mitochondrial DNA mutations contribute to excessive altitude pulmonary edema by way of elevated oxidative stress and metabolic reprogramming throughout hypobaric hypoxia

Excessive altitude pulmonary edema (HAPE) is skilled by non-acclimatized sea stage people on publicity to excessive altitude hypoxic circumstances. Obtainable proof means that genetic elements and perturbed mitochondrial redox standing could play an vital position in HAPE pathophysiology. Nevertheless, the exact mechanism has not been absolutely understood.
Within the current research, sequencing of mitochondrial DNA (mtDNA) from HAPE topics and acclimatized controls was carried out to establish pathogenic mutations and to find out their position in HAPE. Hypobaric hypoxia induced oxidative stress and metabolic alterations have been additionally assessed in HAPE topics. mtDNA copy quantity, mitochondrial oxidative phosphorylation (mtOXPHOS) exercise, mitochondrial biogenesis have been measured to find out mitochondrial features.
The information revealed that the mutations in Advanced I genes impacts the secondary construction of protein in HAPE topics. Additional, elevated oxidative stress throughout hypobaric hypoxia, decreased mitochondrial biogenesis and mtOXPHOS exercise induced metabolic reprogramming which may contribute to mitochondrial dysfunctions in HAPE people.

Pfu DNA Polymerase (Recombinant)

abx074017-2500U 2500 U
EUR 1528.8

Pfu DNA Polymerase (Recombinant)

abx074017-500U 500 U
EUR 526.8

Recombinant Taq Dna Polymerase

27079804 EACH
EUR 117.6

Recombinant Taq Dna Polymerase

27079806 EACH
EUR 639.6

Taq DNA Polymerase (Recombinant)

abx073521-10000U 10000 U
EUR 710.4

Taq DNA Polymerase (Recombinant)

abx073521-1000U 1000 U
EUR 276

Taq DNA Polymerase (Recombinant)

abx073521-3000U 3000 U
EUR 393.6

Recombinant Pfu DNA Polymerase

7-03322 100U Ask for price

Recombinant Pfu DNA Polymerase

7-03323 500U Ask for price

Recombinant Pfu DNA Polymerase

7-03324 2500U Ask for price

Recombinant Taq DNA Polymerase

7-03634 1,000U Ask for price

Recombinant Taq DNA Polymerase

7-03635 3,000U Ask for price

Recombinant Taq DNA Polymerase

7-03636 10,000U Ask for price

Taq DNA Polymerase (Recombinant)

22060707-1 1,000 Unit (s)
EUR 137.27

Taq DNA Polymerase (Recombinant)

22060707-2 1500 Unit (s)
EUR 182.1

Taq DNA Polymerase (Recombinant)

22060707-3 5000 Unit (s)
EUR 465.77

Taq DNA Polymerase (Recombinant)

22060707-4 10 KU
EUR 840.96

DNA Topoisomerase-I (Recombinant)

20-abx073616
  • EUR 5805.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Recombinant (E.Coli) T4 DNA Ligase

RP-374 20 KU
EUR 196.8

Recombinant human DNA-directed DNA/RNA polymerase mu

P2815 100ug Ask for price
Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu

Taq Plus DNA Polymerase (Recombinant)

abx073522-2500U 2.500 U
EUR 710.4

Taq Plus DNA Polymerase (Recombinant)

abx073522-250U 250 U
EUR 276

Taq Plus DNA Polymerase (Recombinant)

abx073522-750U 750 U
EUR 393.6

Recombinant Taq Plus DNA Polymerase

7-03631 250U Ask for price

Recombinant Taq Plus DNA Polymerase

7-03632 750U Ask for price

Recombinant Taq Plus DNA Polymerase

7-03633 2,500U Ask for price

Recombinant (E.Coli) Taq DNA Polymerase

RP-394 1000 IU
EUR 196.8

Recombinant Uracil DNA Glycosylase (UNG)

4-RPG917Hu01
  • EUR 560.83
  • EUR 273.60
  • EUR 1773.12
  • EUR 671.04
  • EUR 1222.08
  • EUR 451.20
  • EUR 4252.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Uracil DNA Glycosylase expressed in: E.coli

Recombinant Human DNA Topoisomerase-I

7-03658 5µg Ask for price

Recombinant Human DNA Topoisomerase-I

7-03659 20µg Ask for price

Recombinant Human DNA Topoisomerase-I

7-03660 1mg Ask for price

DNA Polymerase beta Recombinant Protein

91-139 0.05 mg
EUR 651.3
Description: Human DNA polymerase beta is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. The activity cannot be affected by Aphidicolin, which is an inhibitor of DNA polymerase beta .

Human DNA Topoisomerase-I (Recombinant)

22060306-1 5 µg
EUR 146.42

Polymerase (DNA directed), beta (Recombinant)

20-abx073237
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

E.Coli Adenine DNA Glycosylase (Recombinant)

20-abx074009
  • EUR 276.00
  • EUR 1946.40
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

Polymerase (DNA directed), lambda (Recombinant)

20-abx073724
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

8-Oxoguanine DNA Glycosylase (Recombinant)

20-abx073274
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

DNA-PKcs recombinant monoclonal antibody

A5876 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human DNA-PKcs for WB, IHC,ELISA

Recombinant DNA Methyltransferase 1 (DNMT1)

4-RPJ244Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Methyltransferase 1 expressed in: E.coli

Recombinant DNA Methyltransferase 3B (DNMT3B)

4-RPJ246Mu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Methyltransferase 3B expressed in: E.coli

DNA Topoisomerase-I 70 kDa (Recombinant)

20-abx073615
  • EUR 5805.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Recombinant (E.Coli) Taq Plus DNA Polymerase

RP-395 250 U
EUR 196.8

Recombinant human DNA repair protein REV1

P2230 100ug Ask for price
Description: Recombinant protein for human DNA repair protein REV1

Recombinant DNA Repair Protein RAD50 (RAD50)

4-RPK111Hu01
  • EUR 700.61
  • EUR 310.80
  • EUR 2297.28
  • EUR 845.76
  • EUR 1571.52
  • EUR 544.80
  • EUR 5563.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli

Recombinant DNA Repair Protein RAD50 (RAD50)

4-RPK111Hu02
  • EUR 700.61
  • EUR 310.80
  • EUR 2297.28
  • EUR 845.76
  • EUR 1571.52
  • EUR 544.80
  • EUR 5563.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli

Recombinant DNA Repair Protein RAD50 (RAD50)

4-RPK111Mu01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Repair Protein RAD50 expressed in: E.coli

Recombinant human DNA-binding protein RFX2

P2855 100ug Ask for price
Description: Recombinant protein for human DNA-binding protein RFX2

Recombinant Human DNA Topoisomerase-I 70kDa

7-03661 5µg Ask for price

Recombinant Human DNA Topoisomerase-I 70kDa

7-03662 20µg Ask for price

Recombinant Human DNA Topoisomerase-I 70kDa

7-03663 1mg Ask for price

DNA Ligase IV recombinant monoclonal antibody

A5820 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human DNA Ligase IV for WB, IHC, IF,ELISA

Recombinant DNA expression in Pichia pastoris

HESAP-1002-10G 10G
EUR 2250

Recombinant human DNA-binding protein RFXANK

P2771 100ug Ask for price
Description: Recombinant protein for human DNA-binding protein RFXANK

Recombinant Human DNA Polymerase β (C-6His)

C159-10ug 10ug
EUR 187.2
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human DNA Polymerase β (C-6His)

C159-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human DNA Polymerase β (C-6His)

C159-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human DNA Polymerase β (C-6His)

C159-50ug 50ug
EUR 442.8
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant ATP Dependent DNA ligase I (LIG1)

4-RPB269Hu01
  • EUR 625.34
  • EUR 290.40
  • EUR 2015.04
  • EUR 751.68
  • EUR 1383.36
  • EUR 494.40
  • EUR 4857.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human ATP Dependent DNA ligase I expressed in: E.coli

Recombinant ATP Dependent DNA ligase I (LIG1)

4-RPB269Ra01
  • EUR 646.85
  • EUR 296.40
  • EUR 2095.68
  • EUR 778.56
  • EUR 1437.12
  • EUR 508.80
  • EUR 5059.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat ATP Dependent DNA ligase I expressed in: E.coli

Recombinant Human 8-Oxoguanine DNA Glycosylase

7-03277 5µg Ask for price

Recombinant Human 8-Oxoguanine DNA Glycosylase

7-03278 20µg Ask for price

Recombinant Human 8-Oxoguanine DNA Glycosylase

7-03279 1mg Ask for price

Recombinant N-Methylpurine DNA Glycosylase (MPG)

4-RPH625Hu01
  • EUR 573.73
  • EUR 277.20
  • EUR 1821.50
  • EUR 687.17
  • EUR 1254.34
  • EUR 459.60
  • EUR 4373.76
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human N-Methylpurine DNA Glycosylase expressed in: E.coli

Recombinant N-Methylpurine DNA Glycosylase (MPG)

4-RPH625Mu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse N-Methylpurine DNA Glycosylase expressed in: E.coli

Recombinant N-Methylpurine DNA Glycosylase (MPG)

4-RPH625Ra01
  • EUR 625.34
  • EUR 290.40
  • EUR 2015.04
  • EUR 751.68
  • EUR 1383.36
  • EUR 494.40
  • EUR 4857.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat N-Methylpurine DNA Glycosylase expressed in: E.coli

Recombinant CMV ICP36 DNA Binding Protein [GST]

VAng-Lsx0042-inquire inquire Ask for price
Description: CMV ICP36 DNA Binding Protein [GST], recombinant protein from E. coli.

Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1)

4-RPC785Mu01
  • EUR 474.82
  • EUR 250.80
  • EUR 1450.56
  • EUR 563.52
  • EUR 1007.04
  • EUR 393.60
  • EUR 3446.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli

Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1)

4-RPC785Ra01
  • EUR 485.57
  • EUR 253.20
  • EUR 1490.88
  • EUR 576.96
  • EUR 1033.92
  • EUR 400.80
  • EUR 3547.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli

Recombinant Single-stranded DNA Binding Protein

TTOPP-1902 100ug Ask for price

DNA Polymerase beta recombinant monoclonal antibody

A5473 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human DNA Polymerase beta for WB,ELISA

TOP1 DNA Topoisomerase-IHuman Recombinant Protein

PROTP11387-1 Regular: 20ug
EUR 380.4
Description: DNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 Dalton (excluding glycosilation) 102 kDa total mass. The TOP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.

Recombinant Tar DNA Binding Protein 43kDa (TDP43)

4-RPB951Hu01
  • EUR 588.79
  • EUR 280.80
  • EUR 1877.95
  • EUR 705.98
  • EUR 1291.97
  • EUR 469.20
  • EUR 4514.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Tar DNA Binding Protein 43kDa expressed in: E.coli

Recombinant Tar DNA Binding Protein 43kDa (TDP43)

4-RPB951Mu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Tar DNA Binding Protein 43kDa expressed in: E.coli

Recombinant human DNA topoisomerase I, mitochondrial

P2243 100ug Ask for price
Description: Recombinant protein for human DNA topoisomerase I, mitochondrial

Recombinant human DNA polymerase delta subunit 2

P2733 100ug Ask for price
Description: Recombinant protein for human DNA polymerase delta subunit 2

Recombinant Polymerase DNA Directed Delta 1 (POLd)

4-RPC717Hu01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Polymerase DNA Directed Delta 1 expressed in: E.coli

Recombinant human DNA polymerase subunit gamma-1

P2838 100ug Ask for price
Description: Recombinant protein for human DNA polymerase subunit gamma-1

Recombinant Polymerase DNA Directed Alpha 1 (POLa1)

4-RPC713Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Polymerase DNA Directed Alpha 1 expressed in: E.coli

Recombinant Polymerase DNA Directed Alpha 1 (POLa1)

4-RPC713Mu01
  • EUR 578.04
  • EUR 278.40
  • EUR 1837.63
  • EUR 692.54
  • EUR 1265.09
  • EUR 462.00
  • EUR 4414.08
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Polymerase DNA Directed Alpha 1 expressed in: E.coli

Recombinant Polymerase DNA Directed Gamma 1 (POLg1)

4-RPF723Hu01
  • EUR 560.83
  • EUR 273.60
  • EUR 1773.12
  • EUR 671.04
  • EUR 1222.08
  • EUR 451.20
  • EUR 4252.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Polymerase DNA Directed Gamma 1 expressed in: E.coli

DNA Polymerase Delta Subunit 2 Recombinant Protein

92-121 0.05 mg
EUR 852.9
Description: DNA Polymerase Delta Subunit 2 (POLD2) belongs to the DNA polymerase delta/II small subunit family. POLD2 can form a heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. POLD2 possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. POLD2 is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA).

UNG Uracil DNA Glycosylase E.Coli Recombinant Protein

PROTP12295 Regular: 10ug
EUR 380.4
Description: UNG E.Coli Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229 a.a) and having a molecular mass of 28.1kDa.

Recombinant Human DNA Lyase/OGG1 Protein, Gst Tag

E40KMH992 20ug
EUR 495

Recombinant Human DNA Damage Inducible Transcript 3

7-04969 5µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 3

7-04970 20µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 3

7-04971 1mg Ask for price

Recombinant Human DNA Damage Inducible Transcript 4

7-04972 2µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 4

7-04973 10µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 4

7-04974 1mg Ask for price

Recombinant DNA Damage Inducible Transcript 3 (DDIT3)

4-RPJ282Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Damage Inducible Transcript 3 expressed in: E.coli

Recombinant DNA Damage Inducible Transcript 3 (DDIT3)

4-RPJ282Mu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Damage Inducible Transcript 3 expressed in: E.coli

DNA Damage Inducible Transcript 3 Human (Recombinant)

22060953-1 5 µg
EUR 137.27

DNA Damage Inducible Transcript 4 (Recombinant) Human

22060954-1 2 µg
EUR 137.27

DNA Binding Protein-7 (DBP-7), human recombinant

7603-100 each
EUR 705.6

DNA Binding Protein-7 (DBP-7), human recombinant

7603-1000 each
EUR 3909.6

DNA Binding Protein-7 (DBP-7), human recombinant

7603-20 each
EUR 294

Thymine-DNA Glycosylase (Recombinant)

20-abx073364
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

MutY Adenine DNA Glycosylase E.Coli Recombinant Protein

PROTP17802 Regular: 5ug
EUR 380.4
Description: MutY Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 373 amino acids (1-350) and having a molecular mass of 41.5kDa. MutY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant E.coli DNA ligase Protein, His, E.coli-1mg

QP7075-1mg 1mg
EUR 3037.2

Recombinant CAdV-1 DNA polymerase (POL) (aa 1-1149)

VAng-Cr4088-inquire inquire Ask for price
Description: CAdV-1 (strain CLL) DNA polymerase (POL), recombinant protein.

Recombinant Human p53 and DNA-Damage Regulated 1

7-05842 5µg Ask for price

Recombinant Human p53 and DNA-Damage Regulated 1

7-05843 20µg Ask for price

Recombinant Human p53 and DNA-Damage Regulated 1

7-05844 1mg Ask for price

Recombinant E.coli DNA ligase Protein, His, E.coli-10ug

QP7075-10ug 10ug
EUR 426

Recombinant E.coli DNA ligase Protein, His, E.coli-50ug

QP7075-50ug 50ug
EUR 567.6

p53 and DNA-Damage Regulated 1 Human, Recombinant

22060958-1 5 µg
EUR 137.27

Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa)

4-RPL426Hu01
  • EUR 599.54
  • EUR 283.20
  • EUR 1918.27
  • EUR 719.42
  • EUR 1318.85
  • EUR 476.40
  • EUR 4615.68
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Fragmentation Factor Subunit Alpha expressed in: E.coli

Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa)

4-RPL426Mu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Fragmentation Factor Subunit Alpha expressed in: E.coli

Recombinant E.coli DNA ligase Protein, His, E.coli-100ug

QP7075-100ug 100ug
EUR 925.2

Recombinant E.coli DNA ligase Protein, His, E.coli-200ug

QP7075-200ug 200ug
EUR 1468.8

Recombinant E.coli DNA ligase Protein, His, E.coli-500ug

QP7075-500ug 500ug
EUR 1936.8

Recombinant Human DNA Fragmentation Factor Subunit Alpha

7-04978 5µg Ask for price

Recombinant Human DNA Fragmentation Factor Subunit Alpha

7-04979 25µg Ask for price

Recombinant Human DNA Fragmentation Factor Subunit Alpha

7-04980 1mg Ask for price

Recombinant other T4 DNA Protein, Untagged, E.coli-20,000IU

QP10872-20000IU 20,000IU
EUR 186

DNA Cytosine-5--Methyltransferase 3-Like (Recombinant)

20-abx073992
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Recombinant other T4 DNA Protein, Untagged, E.coli-100,000IU

QP10872-100000IU 100,000IU
EUR 392.4

Recombinant other T4 DNA Protein, Untagged, E.coli-500,000IU

QP10872-500000IU 500,000IU
EUR 1263.6

Recombinant Human DNA Polymerase/POLD2 Protein, His Tag

E40KMH993 20ug
EUR 495

Recombinant Human DNA Polymeraseβ/POLB Protein, His Tag

E40KMH994 20ug
EUR 495

DNAI1 Recombinant Protein (Rat)

RP198266 100 ug Ask for price

DNAI2 Recombinant Protein (Rat)

RP198269 100 ug Ask for price

DNAL1 Recombinant Protein (Rat)

RP198401 100 ug Ask for price

DNAL4 Recombinant Protein (Rat)

RP198404 100 ug Ask for price

Recombinant Damage Specific DNA Binding Protein 2 (DDB2)

4-RPA319Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Damage Specific DNA Binding Protein 2 expressed in: E.coli

Recombinant Damage Specific DNA Binding Protein 2 (DDB2)

4-RPA319Mu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Damage Specific DNA Binding Protein 2 expressed in: E.coli

Dnaaf1 Recombinant Protein (Rat)

RP198257 100 ug Ask for price

Dnaaf2 Recombinant Protein (Rat)

RP198260 100 ug Ask for price

DNAJA1 Recombinant Protein (Rat)

RP198272 100 ug Ask for price

DNAJA2 Recombinant Protein (Rat)

RP198275 100 ug Ask for price

DnaJa3 Recombinant Protein (Rat)

RP198278 100 ug Ask for price

DnaJa3 Recombinant Protein (Rat)

RP198281 100 ug Ask for price

DNAJA4 Recombinant Protein (Rat)

RP198284 100 ug Ask for price

DNAJB1 Recombinant Protein (Rat)

RP198287 100 ug Ask for price

DNAJB2 Recombinant Protein (Rat)

RP198302 100 ug Ask for price

DNAJB3 Recombinant Protein (Rat)

RP198305 100 ug Ask for price

DNAJB4 Recombinant Protein (Rat)

RP198308 100 ug Ask for price

DNAJB5 Recombinant Protein (Rat)

RP198311 100 ug Ask for price

DNAJB6 Recombinant Protein (Rat)

RP198314 100 ug Ask for price

DNAJB7 Recombinant Protein (Rat)

RP198317 100 ug Ask for price

DNAJB8 Recombinant Protein (Rat)

RP198320 100 ug Ask for price

DNAJB9 Recombinant Protein (Rat)

RP198323 100 ug Ask for price

DNAJC2 Recombinant Protein (Rat)

RP198350 100 ug Ask for price

DNAJC3 Recombinant Protein (Rat)

RP198371 100 ug Ask for price

DNAJC4 Recombinant Protein (Rat)

RP198377 100 ug Ask for price

DNAJC5 Recombinant Protein (Rat)

RP198380 100 ug Ask for price

DNAJC7 Recombinant Protein (Rat)

RP198392 100 ug Ask for price

DNAJC8 Recombinant Protein (Rat)

RP198395 100 ug Ask for price

DNAJC9 Recombinant Protein (Rat)

RP198398 100 ug Ask for price

DNALI1 Recombinant Protein (Rat)

RP198407 100 ug Ask for price

DNASE1 Recombinant Protein (Rat)

RP198410 100 ug Ask for price

Recombinant human DNA-binding protein inhibitor ID-1

P1872 100ug Ask for price
Description: Recombinant protein for human DNA-binding protein inhibitor ID-1

TARDBP TAR DNA Binding Protein Human Recombinant Protein

PROTQ13148 Regular: 10ug
EUR 380.4
Description: TARDBP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 296 amino acids (1-260 a.a) and having a molecular mass of 33.6kDa. TARDBP is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant human DNA-directed RNA polymerase, mitochondrial

P2352 100ug Ask for price
Description: Recombinant protein for human DNA-directed RNA polymerase, mitochondrial

Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT)

4-RPC027Hu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human O-6-Methylguanine DNA Methyltransferase expressed in: E.coli

Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT)

4-RPC027Ra01
  • EUR 623.20
  • EUR 290.40
  • EUR 2006.98
  • EUR 748.99
  • EUR 1377.98
  • EUR 492.00
  • EUR 4837.44
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat O-6-Methylguanine DNA Methyltransferase expressed in: E.coli

Recombinant Human DNA ligase 1 Protein, GST, E.coli-1mg

QP6308-ec-1mg 1mg
EUR 1958.4

DNAJB11 Recombinant Protein (Rat)

RP198290 100 ug Ask for price

DNAJB12 Recombinant Protein (Rat)

RP198293 100 ug Ask for price

DNAJB13 Recombinant Protein (Rat)

RP198296 100 ug Ask for price

DNAJB14 Recombinant Protein (Rat)

RP198299 100 ug Ask for price

DNAJC10 Recombinant Protein (Rat)

RP198326 100 ug Ask for price

DNAJC11 Recombinant Protein (Rat)

RP198329 100 ug Ask for price

DNAJC12 Recombinant Protein (Rat)

RP198332 100 ug Ask for price

DNAJC14 Recombinant Protein (Rat)

RP198335 100 ug Ask for price

DNAJC15 Recombinant Protein (Rat)

RP198338 100 ug Ask for price
Haplogroup evaluation means that mtDNA haplogroup H2a2a1 has potential contribution within the pathobiology of HAPE in lowlanders. This research suggests contribution of altered mitochondrial features in HAPE susceptibility.

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