• June 23, 2021
H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage

H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage

Most cancers is likely one of the ailments that threatens human well being and is a number one reason behind mortality worldwide. Excessive ranges of reactive oxygen species (ROS) have been noticed in most cancers tissues in contrast with regular tissues in vivo, and it’s not but recognized how this influences chemotherapeutic drug motion. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer utilized in photodynamic remedy (PDT) and a telomerase inhibitor used within the remedy of telomerase-positive most cancers.
Right here, we investigated the anticancer exercise of TMPyP4 in A549 and PANC cells cultured in H2O2. The outcomes confirmed that in comparison with TMPyP4 alone, the mix of TMPyP4 and H2O2 exhibited sensitization results on cell viability and colony formation inhibition and apoptosis in A549 and PANC cells, however had no impact in human regular MIHA cells.
Mechanistically, the mix of TMPyP4 and H2O2 prompts excessive ROS and mitochondrial membrane potential in A549 and PANC cells, leading to intense DNA harm and DNA harm responses. Consequently, in comparison with TMPyP4 alone, TMPyP4 and H2O2 mixed remedy upregulates the expression of BAX, cleaved caspase 3, and p-JNK and downregulates the expression of Bcl-2 in A549 and PANC cells. Taken collectively, these knowledge prompt that H2O2 enhanced the anticancer exercise of TMPyP4-mediated ROS-dependent DNA harm and associated apoptotic protein regulation, revealing that the excessive ROS tumor microenvironment performs an vital position in chemotherapeutic drug motion.

Survival of an launched ectomycorrhizal Laccaria bicolor pressure in a European forest plantation monitored by mitochondrial ribosomal DNA evaluation

Mitochondrial and nuclear genes have totally different inheritance, thus research of fungal populations ought to use each mitochondrial and nuclear markers. Utilizing nuclear markers, the S238N pressure of the ectomycorrhizal basidiomycete Laccaria bicolor ((Maire) Orton) has been beforehand proven to persist for a minimum of 10 yr after outplanting in a plantation of Douglas fir (Pseudotsuga menziesii (Mir.) Franco) inoculated with this pressure. Within the current research, we’ve got sampled 539 sporophores of Laccaria spp. from this plantation, a few of which had the S238N nuclear genotype, to review mitochondrial DNA polymorphism and persistence of the inoculated S238N mitochondrial genome.
Size polymorphism in fragments of the big subunit of mitochondrial ribosomal DNA (LrDNA) allowed distinction of the haplotypes current within the plantation on the species stage. As well as, heteroduplex evaluation and sequencing revealed intraspecific polymorphism of LrDNA among the many L. bicolor sporophores and enabled particular identification of S238N LrDNA. This haplotype was solely retained in sporophores carrying the S238N nuclear genome, confirming the survival of this launched pressure in a pure inhabitants.

Bioallethrin enhances technology of ROS, damages DNA, impairs the redox system and causes mitochondrial dysfunction in human lymphocytes

Bioallethrin is an artificial pesticide that’s extensively used to manage insect pests. The broad use of bioallethrin has resulted in inevitable human publicity. On this research we report the impact of various concentrations of bioallethrin (10 to 200 µM, 2 h at 37 °C) on human lymphocytes underneath in vitro circumstances. Bioallethrin remedy resulted in lack of cell viability (> 30% at 200 µM bioallethrin). Oxidative stress markers like lipid peroxidation and protein oxidation have been considerably elevated accompanied by decrease ratio of decreased to oxidized glutathione.
H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
Enhanced ROS technology was noticed by way of fluorescence spectroscopy and microscopy. Bioallethrin-induced oxidative stress additionally compromised the antioxidant defence because it decreased antioxidant capability of cells and inhibited main antioxidant enzymes. Biomolecular modifications and systemic toxicity by bioallethrin resulted in plasma membrane harm with mitochondrial depolarization.
Comet assay confirmed nuclear DNA fragmentation and strand scission with vital enhance in tail size and olive tail second. Apoptosis and necrosis of cells was confirmed by way of acridine orange/ethidium bromide twin staining and visualization underneath fluorescence microscope. Thus, bioallethrin causes oxidative harm and compromises the antioxidant system resulting in DNA harm, mobile and organelle toxicity, leading to apoptosis and necrosis of human lymphocytes.

Unearthing Neanderthal inhabitants historical past utilizing nuclear and mitochondrial DNA from cave sediments

Bones and enamel are vital sources of Pleistocene hominin DNA, however are hardly ever recovered at archaeological websites. Mitochondrial DNA has been retrieved from cave sediments, however offers restricted worth for learning inhabitants relationships. We due to this fact developed strategies for the enrichment and evaluation of nuclear DNA from sediments, and utilized them to cave deposits in western Europe and southern Siberia dated to between roughly 200,000 and 50,000 years in the past.
We detect a inhabitants substitute in northern Spain roughly 100,000 years in the past, accompanied by a turnover of mitochondrial DNA. We additionally establish two radiation occasions in Neanderthal historical past through the early a part of the Late Pleistocene. Our work lays the bottom for learning the inhabitants historical past of historical hominins from hint quantities of nuclear DNA in sediments.

Mitochondrial DNA mutations contribute to excessive altitude pulmonary edema by way of elevated oxidative stress and metabolic reprogramming throughout hypobaric hypoxia

Excessive altitude pulmonary edema (HAPE) is skilled by non-acclimatized sea stage people on publicity to excessive altitude hypoxic circumstances. Obtainable proof means that genetic elements and perturbed mitochondrial redox standing could play an vital position in HAPE pathophysiology. Nevertheless, the exact mechanism has not been absolutely understood.
Within the current research, sequencing of mitochondrial DNA (mtDNA) from HAPE topics and acclimatized controls was carried out to establish pathogenic mutations and to find out their position in HAPE. Hypobaric hypoxia induced oxidative stress and metabolic alterations have been additionally assessed in HAPE topics. mtDNA copy quantity, mitochondrial oxidative phosphorylation (mtOXPHOS) exercise, mitochondrial biogenesis have been measured to find out mitochondrial features.
The information revealed that the mutations in Advanced I genes impacts the secondary construction of protein in HAPE topics. Additional, elevated oxidative stress throughout hypobaric hypoxia, decreased mitochondrial biogenesis and mtOXPHOS exercise induced metabolic reprogramming which may contribute to mitochondrial dysfunctions in HAPE people.

Recombinant Pfu DNA Polymerase

7-03324 2500U Ask for price

Recombinant T4 DNA Ligase

7-03622 20,000IU Ask for price

Recombinant T4 DNA Ligase

7-03623 100,000IU Ask for price

Recombinant T4 DNA Ligase

7-03624 500,000IU Ask for price

Recombinant Taq DNA Polymerase

7-03634 1,000U Ask for price

Recombinant Taq DNA Polymerase

7-03635 3,000U Ask for price

Recombinant Taq DNA Polymerase

7-03636 10,000U Ask for price

T4 DNA Ligase (Recombinant)

abx073011-100000IU 100.000 IU
EUR 610.8

T4 DNA Ligase (Recombinant)

abx073011-20000IU 20.000 IU
EUR 309.6

T4 DNA Ligase (Recombinant)

abx073011-500000IU 500.000 IU
EUR 1846.8

Thymine-DNA Glycosylase (Recombinant)

20-abx073364
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Taq DNA Polymerase (Recombinant)

abx073521-10000U 10000 U
EUR 710.4

Taq DNA Polymerase (Recombinant)

abx073521-1000U 1000 U
EUR 276

Taq DNA Polymerase (Recombinant)

abx073521-3000U 3000 U
EUR 393.6

DNA Topoisomerase-I (Recombinant)

20-abx073616
  • EUR 5805.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

Pfu DNA Polymerase (Recombinant)

abx074017-100U 100 U
EUR 393.6

Pfu DNA Polymerase (Recombinant)

abx074017-2500U 2500 U
EUR 1528.8

Pfu DNA Polymerase (Recombinant)

abx074017-500U 500 U
EUR 526.8

Recombinant Taq Dna Polymerase

27079804 EACH
EUR 99.18

Recombinant Taq Dna Polymerase

27079806 EACH
EUR 539.22

Genomic DNA - Rat Male

D1434999-G01 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Genomic DNA - Rat Female

D1434999-G02 100 ug
EUR 225.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Rat Methylated DNA Control

D6434149 5 ug Ask for price
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

n-DNA-Ab/ Rat n- DNA- Ab ELISA Kit

ELA-E1126r 96 Tests
EUR 1063.2

Recombinant Taq Plus DNA Polymerase

7-03631 250U Ask for price

Recombinant Taq Plus DNA Polymerase

7-03632 750U Ask for price

Recombinant Taq Plus DNA Polymerase

7-03633 2,500U Ask for price

Recombinant Human DNA Topoisomerase-I

7-03658 5µg Ask for price

Recombinant Human DNA Topoisomerase-I

7-03659 20µg Ask for price

Recombinant Human DNA Topoisomerase-I

7-03660 1mg Ask for price

DNA Polymerase beta Recombinant Protein

91-139 0.05 mg
EUR 651.3
Description: Human DNA polymerase beta is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. The activity cannot be affected by Aphidicolin, which is an inhibitor of DNA polymerase beta .

Polymerase (DNA directed), beta (Recombinant)

20-abx073237
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

8-Oxoguanine DNA Glycosylase (Recombinant)

20-abx073274
  • EUR 4101.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 25 ug
  • 5 ug

Taq Plus DNA Polymerase (Recombinant)

abx073522-2500U 2.500 U
EUR 710.4

Taq Plus DNA Polymerase (Recombinant)

abx073522-250U 250 U
EUR 276

Taq Plus DNA Polymerase (Recombinant)

abx073522-750U 750 U
EUR 393.6

N-Methylpurine-DNA Glycosylase (Recombinant)

20-abx073622
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Polymerase (DNA directed), lambda (Recombinant)

20-abx073724
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

E.Coli Formamidopyrimidine-DNA Glycosylase (Recombinant)

20-abx073795
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Tyrosyl-DNA Phosphodiesterase 2 (Recombinant)

20-abx073819
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

E.Coli Adenine DNA Glycosylase (Recombinant)

20-abx074009
  • EUR 276.00
  • EUR 1946.40
  • EUR 393.60
  • 1 µg
  • 50 ug
  • 5 ug

DNA-PKcs recombinant monoclonal antibody

A5876 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human DNA-PKcs for WB, IHC,ELISA

Recombinant Uracil DNA Glycosylase (UNG)

4-RPG917Hu01
  • EUR 560.83
  • EUR 273.60
  • EUR 1773.12
  • EUR 671.04
  • EUR 1222.08
  • EUR 451.20
  • EUR 4252.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Uracil DNA Glycosylase expressed in: E.coli

Recombinant DNA Methyltransferase 1 (DNMT1)

4-RPJ244Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Methyltransferase 1 expressed in: E.coli

Recombinant DNA Methyltransferase 3B (DNMT3B)

4-RPJ246Mu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Methyltransferase 3B expressed in: E.coli

Recombinant (E.Coli) T4 DNA Ligase

RP-374 20 KU
EUR 196.8

Recombinant (E.Coli) Taq DNA Polymerase

RP-394 1000 IU
EUR 196.8

Rat Anti-DNA ELISA Kit

ERD0216 96Tests
EUR 625.2

Recombinant Human N-Methylpurine-DNA Glycosylase

7-03169 2µg Ask for price

Recombinant Human N-Methylpurine-DNA Glycosylase

7-03170 10µg Ask for price

Recombinant Human N-Methylpurine-DNA Glycosylase

7-03171 1mg Ask for price

Recombinant Human 8-Oxoguanine DNA Glycosylase

7-03277 5µg Ask for price

Recombinant Human 8-Oxoguanine DNA Glycosylase

7-03278 20µg Ask for price

Recombinant Human 8-Oxoguanine DNA Glycosylase

7-03279 1mg Ask for price

Recombinant Human DNA Topoisomerase-I 70kDa

7-03661 5µg Ask for price

Recombinant Human DNA Topoisomerase-I 70kDa

7-03662 20µg Ask for price

Recombinant Human DNA Topoisomerase-I 70kDa

7-03663 1mg Ask for price

DNA Polymerase beta recombinant monoclonal antibody

A5473 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human DNA Polymerase beta for WB,ELISA

O-6-Methylguanine-DNA Methyltransferase (Recombinant)

20-abx073555
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

DNA Topoisomerase-I 70 kDa (Recombinant)

20-abx073615
  • EUR 5805.60
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

DNA Ligase IV recombinant monoclonal antibody

A5820 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human DNA Ligase IV for WB, IHC, IF,ELISA

Recombinant human DNA repair protein REV1

P2230 100ug Ask for price
Description: Recombinant protein for human DNA repair protein REV1

Recombinant human DNA topoisomerase I, mitochondrial

P2243 100ug Ask for price
Description: Recombinant protein for human DNA topoisomerase I, mitochondrial

Recombinant human DNA-binding protein RFXANK

P2771 100ug Ask for price
Description: Recombinant protein for human DNA-binding protein RFXANK

Recombinant human DNA-binding protein RFX2

P2855 100ug Ask for price
Description: Recombinant protein for human DNA-binding protein RFX2

TOP1 DNA Topoisomerase-IHuman Recombinant Protein

PROTP11387-1 Regular: 20ug
EUR 380.4
Description: DNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 Dalton (excluding glycosilation) 102 kDa total mass. The TOP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.

Recombinant N-Methylpurine DNA Glycosylase (MPG)

4-RPH625Hu01
  • EUR 573.73
  • EUR 277.20
  • EUR 1821.50
  • EUR 687.17
  • EUR 1254.34
  • EUR 459.60
  • EUR 4373.76
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human N-Methylpurine DNA Glycosylase expressed in: E.coli

Recombinant N-Methylpurine DNA Glycosylase (MPG)

4-RPH625Mu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse N-Methylpurine DNA Glycosylase expressed in: E.coli

Recombinant N-Methylpurine DNA Glycosylase (MPG)

4-RPH625Ra01
  • EUR 625.34
  • EUR 290.40
  • EUR 2015.04
  • EUR 751.68
  • EUR 1383.36
  • EUR 494.40
  • EUR 4857.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat N-Methylpurine DNA Glycosylase expressed in: E.coli

Recombinant DNA Repair Protein RAD50 (RAD50)

4-RPK111Hu01
  • EUR 700.61
  • EUR 310.80
  • EUR 2297.28
  • EUR 845.76
  • EUR 1571.52
  • EUR 544.80
  • EUR 5563.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli

Recombinant DNA Repair Protein RAD50 (RAD50)

4-RPK111Hu02
  • EUR 700.61
  • EUR 310.80
  • EUR 2297.28
  • EUR 845.76
  • EUR 1571.52
  • EUR 544.80
  • EUR 5563.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli

Recombinant DNA Repair Protein RAD50 (RAD50)

4-RPK111Mu01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Repair Protein RAD50 expressed in: E.coli

Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1)

4-RPC785Mu01
  • EUR 474.82
  • EUR 250.80
  • EUR 1450.56
  • EUR 563.52
  • EUR 1007.04
  • EUR 393.60
  • EUR 3446.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli

Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1)

4-RPC785Ra01
  • EUR 485.57
  • EUR 253.20
  • EUR 1490.88
  • EUR 576.96
  • EUR 1033.92
  • EUR 400.80
  • EUR 3547.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli

Recombinant (E.Coli) Taq Plus DNA Polymerase

RP-395 250 U
EUR 196.8

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-.1 100 uL/well(10 mM solution)
EUR 4666.8

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-.25 250 uL/well(10 mM solution)
EUR 8286

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-5 5 mg/well
EUR 10806

DNA antibody

10-D20A 500 ug
EUR 591.6
Description: Mouse monoclonal DNA antibody

T7 DNA

310-005 200µg
EUR 98.4

T7 DNA

310-025 5x200 µg
EUR 270

DNA antibody

10C-CR6034M1 100 ug
EUR 289.2
Description: Mouse monoclonal DNA antibody

DNA antibody

10R-D114b 100 ug
EUR 672
Description: Mouse monoclonal DNA antibody

DNA Antibody

abx023805-02mg 0.2 mg
EUR 777.6

DNA Polymerase

ABF5235 100 ug
EUR 525.6

DNA pol

ABF9055 100 ug
EUR 525.6

DNA Polymerase

ABD3082 100 ug
EUR 525.6

DNA-Fect

DF37100-1 1 ml
EUR 418.8

DNA-Fect293

DF37293-1 1 ml
EUR 349.2

DNA-fectamine

DNAF001 1ml
EUR 334.57

pBR322 DNA

MSD14 50ug
EUR 183.19

pUC18 DNA

G40-300 50µg
EUR 67.2

pUC18 DNA

G40-305 5x50µg
EUR 176.4

Rat N-DNA-AB ELISA Kit

ERN0082 96Tests
EUR 625.2

Rat Mitochondrial DNA Copy Number Kit

MCN2 1 Kit
EUR 418.8

Rat DNA Methyltransferase 1 ELISA kit

E02D0320-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 1 ELISA kit

E02D0320-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 1 ELISA kit

E02D0320-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 3A ELISA kit

E02D0321-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 3A ELISA kit

E02D0321-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 3A ELISA kit

E02D0321-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 3beta ELISA kit

E02D0322-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3beta in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 3beta ELISA kit

E02D0322-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3beta in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA Methyltransferase 3beta ELISA kit

E02D0322-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3beta in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Uracil DNA Glycosylase ELISA kit

E02U0076-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Uracil DNA Glycosylase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Uracil DNA Glycosylase ELISA kit

E02U0076-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Uracil DNA Glycosylase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Uracil DNA Glycosylase ELISA kit

E02U0076-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Uracil DNA Glycosylase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA (Double Stranded) ELISA kit

E02A0440-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat DNA (Double Stranded) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA (Double Stranded) ELISA kit

E02A0440-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat DNA (Double Stranded) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA (Double Stranded) ELISA kit

E02A0440-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat DNA (Double Stranded) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat DNA methyltransferase(DNAM)ELISA Kit

GA-E0805RT-48T 48T
EUR 380.4

Rat DNA methyltransferase(DNAM)ELISA Kit

GA-E0805RT-96T 96T
EUR 595.2

Rat DNA methyltransferase3α(DNAM3α)ELISA Kit

GA-E0807RT-48T 48T
EUR 380.4

Rat DNA methyltransferase3α(DNAM3α)ELISA Kit

GA-E0807RT-96T 96T
EUR 595.2

Rat DNA methyltransferase3α(DNAM3α)ELISA Kit

QY-E10845 96T
EUR 433.2

Rat DNA methyltransferase(DNAM)ELISA Kit

QY-E10847 96T
EUR 433.2

Rat Real-time PCR DNA Quantitation after QPCR DNA Damage Analysis Kit

DD2R 1 Kit
EUR 516

Mouse Anti-DNA Antibody (DNA) ELISA Kit

abx257816-96tests 96 tests
EUR 895.2

DNA Ligase I (DNA Ligase I) Antibody

abx232431-100ug 100 ug
EUR 577.2

Taq DNA polymerase (TQ21) , DNA Aptamer, Biotinylated

AD-146-B Custom Ask for price

Taq DNA polymerase (TQ21) , DNA Aptamer, unlabeled

AD-146-U Custom Ask for price

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)

N150 500 units
EUR 122.4

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)

N152 5x500 units
EUR 472.8

DFS-"HOT" Taq DNA Polymerase (DNA-free sensitive, E-coli. DNA Free)

N154 20x500 units
EUR 1830

Recombinant Human DNA Damage Inducible Transcript 3

7-04969 5µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 3

7-04970 20µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 3

7-04971 1mg Ask for price

Recombinant Human DNA Damage Inducible Transcript 4

7-04972 2µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 4

7-04973 10µg Ask for price

Recombinant Human DNA Damage Inducible Transcript 4

7-04974 1mg Ask for price

Recombinant Human DNA Fragmentation Factor Subunit Alpha

7-04978 5µg Ask for price

Recombinant Human DNA Fragmentation Factor Subunit Alpha

7-04979 25µg Ask for price

Recombinant Human DNA Fragmentation Factor Subunit Alpha

7-04980 1mg Ask for price

Recombinant Human O-6-Methylguanine-DNA Methyltransferase

7-03133 5µg Ask for price

Recombinant Human O-6-Methylguanine-DNA Methyltransferase

7-03134 20µg Ask for price

Recombinant Human O-6-Methylguanine-DNA Methyltransferase

7-03135 1mg Ask for price

DNA Polymerase Delta Subunit 2 Recombinant Protein

92-121 0.05 mg
EUR 852.9
Description: DNA Polymerase Delta Subunit 2 (POLD2) belongs to the DNA polymerase delta/II small subunit family. POLD2 can form a heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. POLD2 possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. POLD2 is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA).

DNA Cytosine-5--Methyltransferase 3-Like (Recombinant)

20-abx073992
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Recombinant Human DNA Polymerase β (C-6His)

C159-10ug 10ug
EUR 187.2
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human DNA Polymerase β (C-6His)

C159-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human DNA Polymerase β (C-6His)

C159-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant Human DNA Polymerase β (C-6His)

C159-50ug 50ug
EUR 442.8
Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8.

Recombinant human DNA-directed RNA polymerase, mitochondrial

P2352 100ug Ask for price
Description: Recombinant protein for human DNA-directed RNA polymerase, mitochondrial

Recombinant human DNA polymerase delta subunit 2

P2733 100ug Ask for price
Description: Recombinant protein for human DNA polymerase delta subunit 2

Recombinant human DNA polymerase subunit gamma-1

P2838 100ug Ask for price
Description: Recombinant protein for human DNA polymerase subunit gamma-1

MUTM Formamidopyrimidine-DNA Glycosylase E.Coli Recombinant Protein

PROTP05523 Regular: 10ug
EUR 380.4
Description: MUTM Recombinant produced in E. coli is a single polypeptide chain containing 289 amino acids (1-269) and having a molecular mass of 32.4kDa.;MUTM is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UNG Uracil DNA Glycosylase E.Coli Recombinant Protein

PROTP12295 Regular: 10ug
EUR 380.4
Description: UNG E.Coli Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229 a.a) and having a molecular mass of 28.1kDa.

MutY Adenine DNA Glycosylase E.Coli Recombinant Protein

PROTP17802 Regular: 5ug
EUR 380.4
Description: MutY Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 373 amino acids (1-350) and having a molecular mass of 41.5kDa. MutY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

TDG Thymine-DNA Glycosylase Human Recombinant Protein

PROTQ13569 Regular: 20ug
EUR 380.4
Description: TDG Human Recombinant produced in E. coli is a single polypeptide chain containing 433 amino acids (1-410) and having a molecular mass of 48.4 kDa.;TDG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant ATP Dependent DNA ligase I (LIG1)

4-RPB269Hu01
  • EUR 625.34
  • EUR 290.40
  • EUR 2015.04
  • EUR 751.68
  • EUR 1383.36
  • EUR 494.40
  • EUR 4857.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human ATP Dependent DNA ligase I expressed in: E.coli

Recombinant ATP Dependent DNA ligase I (LIG1)

4-RPB269Ra01
  • EUR 646.85
  • EUR 296.40
  • EUR 2095.68
  • EUR 778.56
  • EUR 1437.12
  • EUR 508.80
  • EUR 5059.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat ATP Dependent DNA ligase I expressed in: E.coli

Recombinant Tar DNA Binding Protein 43kDa (TDP43)

4-RPB951Hu01
  • EUR 588.79
  • EUR 280.80
  • EUR 1877.95
  • EUR 705.98
  • EUR 1291.97
  • EUR 469.20
  • EUR 4514.88
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Tar DNA Binding Protein 43kDa expressed in: E.coli

Recombinant Tar DNA Binding Protein 43kDa (TDP43)

4-RPB951Mu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Tar DNA Binding Protein 43kDa expressed in: E.coli

Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT)

4-RPC027Hu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human O-6-Methylguanine DNA Methyltransferase expressed in: E.coli

Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT)

4-RPC027Ra01
  • EUR 623.20
  • EUR 290.40
  • EUR 2006.98
  • EUR 748.99
  • EUR 1377.98
  • EUR 492.00
  • EUR 4837.44
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat O-6-Methylguanine DNA Methyltransferase expressed in: E.coli

Recombinant DNA Damage Inducible Transcript 3 (DDIT3)

4-RPJ282Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Damage Inducible Transcript 3 expressed in: E.coli

Recombinant DNA Damage Inducible Transcript 3 (DDIT3)

4-RPJ282Mu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Damage Inducible Transcript 3 expressed in: E.coli

Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa)

4-RPL426Hu01
  • EUR 599.54
  • EUR 283.20
  • EUR 1918.27
  • EUR 719.42
  • EUR 1318.85
  • EUR 476.40
  • EUR 4615.68
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human DNA Fragmentation Factor Subunit Alpha expressed in: E.coli

Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa)

4-RPL426Mu01
  • EUR 593.09
  • EUR 282.00
  • EUR 1894.08
  • EUR 711.36
  • EUR 1302.72
  • EUR 472.80
  • EUR 4555.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse DNA Fragmentation Factor Subunit Alpha expressed in: E.coli

Recombinant Z-DNA Binding Protein 1 (ZBP1)

4-RPB552Hu01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Z-DNA Binding Protein 1 expressed in: E.coli

Recombinant Polymerase DNA Directed Gamma 1 (POLg1)

4-RPF723Hu01
  • EUR 560.83
  • EUR 273.60
  • EUR 1773.12
  • EUR 671.04
  • EUR 1222.08
  • EUR 451.20
  • EUR 4252.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Polymerase DNA Directed Gamma 1 expressed in: E.coli

Recombinant Polymerase DNA Directed Alpha 1 (POLa1)

4-RPC713Hu01
  • EUR 582.34
  • EUR 279.60
  • EUR 1853.76
  • EUR 697.92
  • EUR 1275.84
  • EUR 465.60
  • EUR 4454.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Polymerase DNA Directed Alpha 1 expressed in: E.coli

Recombinant Polymerase DNA Directed Alpha 1 (POLa1)

4-RPC713Mu01
  • EUR 578.04
  • EUR 278.40
  • EUR 1837.63
  • EUR 692.54
  • EUR 1265.09
  • EUR 462.00
  • EUR 4414.08
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Polymerase DNA Directed Alpha 1 expressed in: E.coli

Recombinant Polymerase DNA Directed Delta 1 (POLd)

4-RPC717Hu01
  • EUR 571.58
  • EUR 276.00
  • EUR 1813.44
  • EUR 684.48
  • EUR 1248.96
  • EUR 458.40
  • EUR 4353.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Polymerase DNA Directed Delta 1 expressed in: E.coli

Recombinant CMV ICP36 DNA Binding Protein [GST]

VAng-Lsx0042-inquire inquire Ask for price
Description: CMV ICP36 DNA Binding Protein [GST], recombinant protein from E. coli.

Rat N-Methylpurine DNA Glycosylase (MPG) Protein

20-abx068316
  • EUR 878.40
  • EUR 343.20
  • EUR 2715.60
  • EUR 1045.20
  • EUR 627.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
Haplogroup evaluation means that mtDNA haplogroup H2a2a1 has potential contribution within the pathobiology of HAPE in lowlanders. This research suggests contribution of altered mitochondrial features in HAPE susceptibility.

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