H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
Most cancers is likely one of the ailments that threatens human well being and is a number one reason behind mortality worldwide. Excessive ranges of reactive oxygen species (ROS) have been noticed in most cancers tissues in contrast with regular tissues in vivo, and it’s not but recognized how this influences chemotherapeutic drug motion. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer utilized in photodynamic remedy (PDT) and a telomerase inhibitor used within the remedy of telomerase-positive most cancers.
Right here, we investigated the anticancer exercise of TMPyP4 in A549 and PANC cells cultured in H2O2. The outcomes confirmed that in comparison with TMPyP4 alone, the mix of TMPyP4 and H2O2 exhibited sensitization results on cell viability and colony formation inhibition and apoptosis in A549 and PANC cells, however had no impact in human regular MIHA cells.
Mechanistically, the mix of TMPyP4 and H2O2 prompts excessive ROS and mitochondrial membrane potential in A549 and PANC cells, leading to intense DNA harm and DNA harm responses. Consequently, in comparison with TMPyP4 alone, TMPyP4 and H2O2 mixed remedy upregulates the expression of BAX, cleaved caspase 3, and p-JNK and downregulates the expression of Bcl-2 in A549 and PANC cells. Taken collectively, these knowledge prompt that H2O2 enhanced the anticancer exercise of TMPyP4-mediated ROS-dependent DNA harm and associated apoptotic protein regulation, revealing that the excessive ROS tumor microenvironment performs an vital position in chemotherapeutic drug motion.
Survival of an launched ectomycorrhizal Laccaria bicolor pressure in a European forest plantation monitored by mitochondrial ribosomal DNA evaluation
Mitochondrial and nuclear genes have totally different inheritance, thus research of fungal populations ought to use each mitochondrial and nuclear markers. Utilizing nuclear markers, the S238N pressure of the ectomycorrhizal basidiomycete Laccaria bicolor ((Maire) Orton) has been beforehand proven to persist for a minimum of 10 yr after outplanting in a plantation of Douglas fir (Pseudotsuga menziesii (Mir.) Franco) inoculated with this pressure. Within the current research, we’ve got sampled 539 sporophores of Laccaria spp. from this plantation, a few of which had the S238N nuclear genotype, to review mitochondrial DNA polymorphism and persistence of the inoculated S238N mitochondrial genome.
Size polymorphism in fragments of the big subunit of mitochondrial ribosomal DNA (LrDNA) allowed distinction of the haplotypes current within the plantation on the species stage. As well as, heteroduplex evaluation and sequencing revealed intraspecific polymorphism of LrDNA among the many L. bicolor sporophores and enabled particular identification of S238N LrDNA. This haplotype was solely retained in sporophores carrying the S238N nuclear genome, confirming the survival of this launched pressure in a pure inhabitants.
Bioallethrin enhances technology of ROS, damages DNA, impairs the redox system and causes mitochondrial dysfunction in human lymphocytes
Bioallethrin is an artificial pesticide that’s extensively used to manage insect pests. The broad use of bioallethrin has resulted in inevitable human publicity. On this research we report the impact of various concentrations of bioallethrin (10 to 200 µM, 2 h at 37 °C) on human lymphocytes underneath in vitro circumstances. Bioallethrin remedy resulted in lack of cell viability (> 30% at 200 µM bioallethrin). Oxidative stress markers like lipid peroxidation and protein oxidation have been considerably elevated accompanied by decrease ratio of decreased to oxidized glutathione.
Enhanced ROS technology was noticed by way of fluorescence spectroscopy and microscopy. Bioallethrin-induced oxidative stress additionally compromised the antioxidant defence because it decreased antioxidant capability of cells and inhibited main antioxidant enzymes. Biomolecular modifications and systemic toxicity by bioallethrin resulted in plasma membrane harm with mitochondrial depolarization.
Comet assay confirmed nuclear DNA fragmentation and strand scission with vital enhance in tail size and olive tail second. Apoptosis and necrosis of cells was confirmed by way of acridine orange/ethidium bromide twin staining and visualization underneath fluorescence microscope. Thus, bioallethrin causes oxidative harm and compromises the antioxidant system resulting in DNA harm, mobile and organelle toxicity, leading to apoptosis and necrosis of human lymphocytes.
Unearthing Neanderthal inhabitants historical past utilizing nuclear and mitochondrial DNA from cave sediments
Bones and enamel are vital sources of Pleistocene hominin DNA, however are hardly ever recovered at archaeological websites. Mitochondrial DNA has been retrieved from cave sediments, however offers restricted worth for learning inhabitants relationships. We due to this fact developed strategies for the enrichment and evaluation of nuclear DNA from sediments, and utilized them to cave deposits in western Europe and southern Siberia dated to between roughly 200,000 and 50,000 years in the past.
We detect a inhabitants substitute in northern Spain roughly 100,000 years in the past, accompanied by a turnover of mitochondrial DNA. We additionally establish two radiation occasions in Neanderthal historical past through the early a part of the Late Pleistocene. Our work lays the bottom for learning the inhabitants historical past of historical hominins from hint quantities of nuclear DNA in sediments.
Mitochondrial DNA mutations contribute to excessive altitude pulmonary edema by way of elevated oxidative stress and metabolic reprogramming throughout hypobaric hypoxia
Excessive altitude pulmonary edema (HAPE) is skilled by non-acclimatized sea stage people on publicity to excessive altitude hypoxic circumstances. Obtainable proof means that genetic elements and perturbed mitochondrial redox standing could play an vital position in HAPE pathophysiology. Nevertheless, the exact mechanism has not been absolutely understood.
Within the current research, sequencing of mitochondrial DNA (mtDNA) from HAPE topics and acclimatized controls was carried out to establish pathogenic mutations and to find out their position in HAPE. Hypobaric hypoxia induced oxidative stress and metabolic alterations have been additionally assessed in HAPE topics. mtDNA copy quantity, mitochondrial oxidative phosphorylation (mtOXPHOS) exercise, mitochondrial biogenesis have been measured to find out mitochondrial features.
The information revealed that the mutations in Advanced I genes impacts the secondary construction of protein in HAPE topics. Additional, elevated oxidative stress throughout hypobaric hypoxia, decreased mitochondrial biogenesis and mtOXPHOS exercise induced metabolic reprogramming which may contribute to mitochondrial dysfunctions in HAPE people.
Pfu DNA Polymerase (Recombinant) |
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| abx074017-2500U | Abbexa | 2500 U | EUR 1528.8 |
Pfu DNA Polymerase (Recombinant) |
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| abx074017-500U | Abbexa | 500 U | EUR 526.8 |
Recombinant Taq Dna Polymerase |
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| 27079804 | Scientific Laboratory Supplies | EACH | EUR 117.6 |
Recombinant Taq Dna Polymerase |
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| 27079806 | Scientific Laboratory Supplies | EACH | EUR 639.6 |
Taq DNA Polymerase (Recombinant) |
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| abx073521-10000U | Abbexa | 10000 U | EUR 710.4 |
Taq DNA Polymerase (Recombinant) |
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| abx073521-1000U | Abbexa | 1000 U | EUR 276 |
Taq DNA Polymerase (Recombinant) |
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| abx073521-3000U | Abbexa | 3000 U | EUR 393.6 |
Recombinant Pfu DNA Polymerase |
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| 7-03322 | CHI Scientific | 100U | Ask for price |
Recombinant Pfu DNA Polymerase |
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| 7-03323 | CHI Scientific | 500U | Ask for price |
Recombinant Pfu DNA Polymerase |
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| 7-03324 | CHI Scientific | 2500U | Ask for price |
Recombinant Taq DNA Polymerase |
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| 7-03634 | CHI Scientific | 1,000U | Ask for price |
Recombinant Taq DNA Polymerase |
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| 7-03635 | CHI Scientific | 3,000U | Ask for price |
Recombinant Taq DNA Polymerase |
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| 7-03636 | CHI Scientific | 10,000U | Ask for price |
Taq DNA Polymerase (Recombinant) |
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| 22060707-1 | Bio-WORLD | 1,000 Unit (s) | EUR 137.27 |
Taq DNA Polymerase (Recombinant) |
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| 22060707-2 | Bio-WORLD | 1500 Unit (s) | EUR 182.1 |
Taq DNA Polymerase (Recombinant) |
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| 22060707-3 | Bio-WORLD | 5000 Unit (s) | EUR 465.77 |
Taq DNA Polymerase (Recombinant) |
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| 22060707-4 | Bio-WORLD | 10 KU | EUR 840.96 |
DNA Topoisomerase-I (Recombinant) |
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| 20-abx073616 | Abbexa |
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Recombinant (E.Coli) T4 DNA Ligase |
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| RP-374 | Alpha Diagnostics | 20 KU | EUR 196.8 |
Recombinant human DNA-directed DNA/RNA polymerase mu |
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| P2815 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu |
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Taq Plus DNA Polymerase (Recombinant) |
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| abx073522-2500U | Abbexa | 2.500 U | EUR 710.4 |
Taq Plus DNA Polymerase (Recombinant) |
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| abx073522-250U | Abbexa | 250 U | EUR 276 |
Taq Plus DNA Polymerase (Recombinant) |
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| abx073522-750U | Abbexa | 750 U | EUR 393.6 |
Recombinant Taq Plus DNA Polymerase |
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| 7-03631 | CHI Scientific | 250U | Ask for price |
Recombinant Taq Plus DNA Polymerase |
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| 7-03632 | CHI Scientific | 750U | Ask for price |
Recombinant Taq Plus DNA Polymerase |
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| 7-03633 | CHI Scientific | 2,500U | Ask for price |
Recombinant (E.Coli) Taq DNA Polymerase |
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| RP-394 | Alpha Diagnostics | 1000 IU | EUR 196.8 |
Recombinant Uracil DNA Glycosylase (UNG) |
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| 4-RPG917Hu01 | Cloud-Clone |
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Description: Recombinant Human Uracil DNA Glycosylase expressed in: E.coli |
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Recombinant Human DNA Topoisomerase-I |
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| 7-03658 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Topoisomerase-I |
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| 7-03659 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Topoisomerase-I |
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| 7-03660 | CHI Scientific | 1mg | Ask for price |
DNA Polymerase beta Recombinant Protein |
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| 91-139 | ProSci | 0.05 mg | EUR 651.3 |
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Description: Human DNA polymerase beta is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. The activity cannot be affected by Aphidicolin, which is an inhibitor of DNA polymerase beta . |
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Human DNA Topoisomerase-I (Recombinant) |
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| 22060306-1 | Bio-WORLD | 5 µg | EUR 146.42 |
Polymerase (DNA directed), beta (Recombinant) |
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| 20-abx073237 | Abbexa |
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E.Coli Adenine DNA Glycosylase (Recombinant) |
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| 20-abx074009 | Abbexa |
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Polymerase (DNA directed), lambda (Recombinant) |
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| 20-abx073724 | Abbexa |
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8-Oxoguanine DNA Glycosylase (Recombinant) |
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| 20-abx073274 | Abbexa |
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DNA-PKcs recombinant monoclonal antibody |
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| A5876 | Bimake | 100ul X 3 | EUR 714 |
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Description: A recombinant monoclonal antibody from rabbit against human DNA-PKcs for WB, IHC,ELISA |
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Recombinant DNA Methyltransferase 1 (DNMT1) |
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| 4-RPJ244Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Methyltransferase 1 expressed in: E.coli |
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Recombinant DNA Methyltransferase 3B (DNMT3B) |
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| 4-RPJ246Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Methyltransferase 3B expressed in: E.coli |
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DNA Topoisomerase-I 70 kDa (Recombinant) |
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| 20-abx073615 | Abbexa |
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Recombinant (E.Coli) Taq Plus DNA Polymerase |
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| RP-395 | Alpha Diagnostics | 250 U | EUR 196.8 |
Recombinant human DNA repair protein REV1 |
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| P2230 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA repair protein REV1 |
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Recombinant DNA Repair Protein RAD50 (RAD50) |
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| 4-RPK111Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
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Recombinant DNA Repair Protein RAD50 (RAD50) |
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| 4-RPK111Hu02 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
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Recombinant DNA Repair Protein RAD50 (RAD50) |
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| 4-RPK111Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Repair Protein RAD50 expressed in: E.coli |
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Recombinant human DNA-binding protein RFX2 |
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| P2855 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-binding protein RFX2 |
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Recombinant Human DNA Topoisomerase-I 70kDa |
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| 7-03661 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Topoisomerase-I 70kDa |
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| 7-03662 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Topoisomerase-I 70kDa |
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| 7-03663 | CHI Scientific | 1mg | Ask for price |
DNA Ligase IV recombinant monoclonal antibody |
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| A5820 | Bimake | 100ul X 3 | EUR 714 |
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Description: A recombinant monoclonal antibody from rabbit against human DNA Ligase IV for WB, IHC, IF,ELISA |
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Recombinant DNA expression in Pichia pastoris |
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| HESAP-1002-10G | Cyagen | 10G | EUR 2250 |
Recombinant human DNA-binding protein RFXANK |
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| P2771 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-binding protein RFXANK |
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Recombinant Human DNA Polymerase β (C-6His) |
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| C159-10ug | Novoprotein | 10ug | EUR 187.2 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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Recombinant Human DNA Polymerase β (C-6His) |
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| C159-1mg | Novoprotein | 1mg | EUR 2739.6 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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Recombinant Human DNA Polymerase β (C-6His) |
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| C159-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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Recombinant Human DNA Polymerase β (C-6His) |
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| C159-50ug | Novoprotein | 50ug | EUR 442.8 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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Recombinant ATP Dependent DNA ligase I (LIG1) |
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| 4-RPB269Hu01 | Cloud-Clone |
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Description: Recombinant Human ATP Dependent DNA ligase I expressed in: E.coli |
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Recombinant ATP Dependent DNA ligase I (LIG1) |
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| 4-RPB269Ra01 | Cloud-Clone |
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Description: Recombinant Rat ATP Dependent DNA ligase I expressed in: E.coli |
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Recombinant Human 8-Oxoguanine DNA Glycosylase |
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| 7-03277 | CHI Scientific | 5µg | Ask for price |
Recombinant Human 8-Oxoguanine DNA Glycosylase |
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| 7-03278 | CHI Scientific | 20µg | Ask for price |
Recombinant Human 8-Oxoguanine DNA Glycosylase |
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| 7-03279 | CHI Scientific | 1mg | Ask for price |
Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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| 4-RPH625Hu01 | Cloud-Clone |
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Description: Recombinant Human N-Methylpurine DNA Glycosylase expressed in: E.coli |
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Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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| 4-RPH625Mu01 | Cloud-Clone |
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Description: Recombinant Mouse N-Methylpurine DNA Glycosylase expressed in: E.coli |
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Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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| 4-RPH625Ra01 | Cloud-Clone |
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Description: Recombinant Rat N-Methylpurine DNA Glycosylase expressed in: E.coli |
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Recombinant CMV ICP36 DNA Binding Protein [GST] |
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| VAng-Lsx0042-inquire | Creative Biolabs | inquire | Ask for price |
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Description: CMV ICP36 DNA Binding Protein [GST], recombinant protein from E. coli. |
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Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) |
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| 4-RPC785Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli |
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Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) |
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| 4-RPC785Ra01 | Cloud-Clone |
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Description: Recombinant Rat Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli |
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Recombinant Single-stranded DNA Binding Protein |
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| TTOPP-1902 | Cyagen | 100ug | Ask for price |
DNA Polymerase beta recombinant monoclonal antibody |
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| A5473 | Bimake | 100ul X 3 | EUR 714 |
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Description: A recombinant monoclonal antibody from rabbit against human DNA Polymerase beta for WB,ELISA |
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TOP1 DNA Topoisomerase-IHuman Recombinant Protein |
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| PROTP11387-1 | BosterBio | Regular: 20ug | EUR 380.4 |
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Description: DNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 Dalton (excluding glycosilation) 102 kDa total mass. The TOP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. |
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Recombinant Tar DNA Binding Protein 43kDa (TDP43) |
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| 4-RPB951Hu01 | Cloud-Clone |
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Description: Recombinant Human Tar DNA Binding Protein 43kDa expressed in: E.coli |
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Recombinant Tar DNA Binding Protein 43kDa (TDP43) |
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| 4-RPB951Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tar DNA Binding Protein 43kDa expressed in: E.coli |
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Recombinant human DNA topoisomerase I, mitochondrial |
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| P2243 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA topoisomerase I, mitochondrial |
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Recombinant human DNA polymerase delta subunit 2 |
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| P2733 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA polymerase delta subunit 2 |
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Recombinant Polymerase DNA Directed Delta 1 (POLd) |
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| 4-RPC717Hu01 | Cloud-Clone |
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Description: Recombinant Human Polymerase DNA Directed Delta 1 expressed in: E.coli |
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Recombinant human DNA polymerase subunit gamma-1 |
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| P2838 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA polymerase subunit gamma-1 |
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Recombinant Polymerase DNA Directed Alpha 1 (POLa1) |
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| 4-RPC713Hu01 | Cloud-Clone |
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Description: Recombinant Human Polymerase DNA Directed Alpha 1 expressed in: E.coli |
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Recombinant Polymerase DNA Directed Alpha 1 (POLa1) |
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| 4-RPC713Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Polymerase DNA Directed Alpha 1 expressed in: E.coli |
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Recombinant Polymerase DNA Directed Gamma 1 (POLg1) |
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| 4-RPF723Hu01 | Cloud-Clone |
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Description: Recombinant Human Polymerase DNA Directed Gamma 1 expressed in: E.coli |
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DNA Polymerase Delta Subunit 2 Recombinant Protein |
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| 92-121 | ProSci | 0.05 mg | EUR 852.9 |
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Description: DNA Polymerase Delta Subunit 2 (POLD2) belongs to the DNA polymerase delta/II small subunit family. POLD2 can form a heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. POLD2 possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. POLD2 is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). |
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UNG Uracil DNA Glycosylase E.Coli Recombinant Protein |
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| PROTP12295 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: UNG E.Coli Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229 a.a) and having a molecular mass of 28.1kDa. |
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Recombinant Human DNA Lyase/OGG1 Protein, Gst Tag |
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| E40KMH992 | EnoGene | 20ug | EUR 495 |
Recombinant Human DNA Damage Inducible Transcript 3 |
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| 7-04969 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 3 |
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| 7-04970 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 3 |
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| 7-04971 | CHI Scientific | 1mg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 4 |
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| 7-04972 | CHI Scientific | 2µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 4 |
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| 7-04973 | CHI Scientific | 10µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 4 |
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| 7-04974 | CHI Scientific | 1mg | Ask for price |
Recombinant DNA Damage Inducible Transcript 3 (DDIT3) |
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| 4-RPJ282Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Damage Inducible Transcript 3 expressed in: E.coli |
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Recombinant DNA Damage Inducible Transcript 3 (DDIT3) |
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| 4-RPJ282Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Damage Inducible Transcript 3 expressed in: E.coli |
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DNA Damage Inducible Transcript 3 Human (Recombinant) |
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| 22060953-1 | Bio-WORLD | 5 µg | EUR 137.27 |
DNA Damage Inducible Transcript 4 (Recombinant) Human |
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| 22060954-1 | Bio-WORLD | 2 µg | EUR 137.27 |
DNA Binding Protein-7 (DBP-7), human recombinant |
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| 7603-100 | Biovision | each | EUR 705.6 |
DNA Binding Protein-7 (DBP-7), human recombinant |
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| 7603-1000 | Biovision | each | EUR 3909.6 |
DNA Binding Protein-7 (DBP-7), human recombinant |
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| 7603-20 | Biovision | each | EUR 294 |
Thymine-DNA Glycosylase (Recombinant) |
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| 20-abx073364 | Abbexa |
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MutY Adenine DNA Glycosylase E.Coli Recombinant Protein |
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| PROTP17802 | BosterBio | Regular: 5ug | EUR 380.4 |
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Description: MutY Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 373 amino acids (1-350) and having a molecular mass of 41.5kDa. MutY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
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Recombinant E.coli DNA ligase Protein, His, E.coli-1mg |
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| QP7075-1mg | EnQuireBio | 1mg | EUR 3037.2 |
Recombinant CAdV-1 DNA polymerase (POL) (aa 1-1149) |
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| VAng-Cr4088-inquire | Creative Biolabs | inquire | Ask for price |
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Description: CAdV-1 (strain CLL) DNA polymerase (POL), recombinant protein. |
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Recombinant Human p53 and DNA-Damage Regulated 1 |
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| 7-05842 | CHI Scientific | 5µg | Ask for price |
Recombinant Human p53 and DNA-Damage Regulated 1 |
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| 7-05843 | CHI Scientific | 20µg | Ask for price |
Recombinant Human p53 and DNA-Damage Regulated 1 |
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| 7-05844 | CHI Scientific | 1mg | Ask for price |
Recombinant E.coli DNA ligase Protein, His, E.coli-10ug |
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| QP7075-10ug | EnQuireBio | 10ug | EUR 426 |
Recombinant E.coli DNA ligase Protein, His, E.coli-50ug |
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| QP7075-50ug | EnQuireBio | 50ug | EUR 567.6 |
p53 and DNA-Damage Regulated 1 Human, Recombinant |
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| 22060958-1 | Bio-WORLD | 5 µg | EUR 137.27 |
Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa) |
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| 4-RPL426Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Fragmentation Factor Subunit Alpha expressed in: E.coli |
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Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa) |
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| 4-RPL426Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Fragmentation Factor Subunit Alpha expressed in: E.coli |
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Recombinant E.coli DNA ligase Protein, His, E.coli-100ug |
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| QP7075-100ug | EnQuireBio | 100ug | EUR 925.2 |
Recombinant E.coli DNA ligase Protein, His, E.coli-200ug |
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| QP7075-200ug | EnQuireBio | 200ug | EUR 1468.8 |
Recombinant E.coli DNA ligase Protein, His, E.coli-500ug |
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| QP7075-500ug | EnQuireBio | 500ug | EUR 1936.8 |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04978 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04979 | CHI Scientific | 25µg | Ask for price |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04980 | CHI Scientific | 1mg | Ask for price |
Recombinant other T4 DNA Protein, Untagged, E.coli-20,000IU |
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| QP10872-20000IU | EnQuireBio | 20,000IU | EUR 186 |
DNA Cytosine-5--Methyltransferase 3-Like (Recombinant) |
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| 20-abx073992 | Abbexa |
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Recombinant other T4 DNA Protein, Untagged, E.coli-100,000IU |
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| QP10872-100000IU | EnQuireBio | 100,000IU | EUR 392.4 |
Recombinant other T4 DNA Protein, Untagged, E.coli-500,000IU |
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| QP10872-500000IU | EnQuireBio | 500,000IU | EUR 1263.6 |
Recombinant Human DNA Polymerase/POLD2 Protein, His Tag |
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| E40KMH993 | EnoGene | 20ug | EUR 495 |
Recombinant Human DNA Polymeraseβ/POLB Protein, His Tag |
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| E40KMH994 | EnoGene | 20ug | EUR 495 |
DNAI1 Recombinant Protein (Rat) |
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| RP198266 | ABM | 100 ug | Ask for price |
DNAI2 Recombinant Protein (Rat) |
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| RP198269 | ABM | 100 ug | Ask for price |
DNAL1 Recombinant Protein (Rat) |
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| RP198401 | ABM | 100 ug | Ask for price |
DNAL4 Recombinant Protein (Rat) |
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| RP198404 | ABM | 100 ug | Ask for price |
Recombinant Damage Specific DNA Binding Protein 2 (DDB2) |
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| 4-RPA319Hu01 | Cloud-Clone |
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Description: Recombinant Human Damage Specific DNA Binding Protein 2 expressed in: E.coli |
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Recombinant Damage Specific DNA Binding Protein 2 (DDB2) |
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| 4-RPA319Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Damage Specific DNA Binding Protein 2 expressed in: E.coli |
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Dnaaf1 Recombinant Protein (Rat) |
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| RP198257 | ABM | 100 ug | Ask for price |
Dnaaf2 Recombinant Protein (Rat) |
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| RP198260 | ABM | 100 ug | Ask for price |
DNAJA1 Recombinant Protein (Rat) |
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| RP198272 | ABM | 100 ug | Ask for price |
DNAJA2 Recombinant Protein (Rat) |
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| RP198275 | ABM | 100 ug | Ask for price |
DnaJa3 Recombinant Protein (Rat) |
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| RP198278 | ABM | 100 ug | Ask for price |
DnaJa3 Recombinant Protein (Rat) |
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| RP198281 | ABM | 100 ug | Ask for price |
DNAJA4 Recombinant Protein (Rat) |
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| RP198284 | ABM | 100 ug | Ask for price |
DNAJB1 Recombinant Protein (Rat) |
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| RP198287 | ABM | 100 ug | Ask for price |
DNAJB2 Recombinant Protein (Rat) |
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| RP198302 | ABM | 100 ug | Ask for price |
DNAJB3 Recombinant Protein (Rat) |
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| RP198305 | ABM | 100 ug | Ask for price |
DNAJB4 Recombinant Protein (Rat) |
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| RP198308 | ABM | 100 ug | Ask for price |
DNAJB5 Recombinant Protein (Rat) |
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| RP198311 | ABM | 100 ug | Ask for price |
DNAJB6 Recombinant Protein (Rat) |
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| RP198314 | ABM | 100 ug | Ask for price |
DNAJB7 Recombinant Protein (Rat) |
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| RP198317 | ABM | 100 ug | Ask for price |
DNAJB8 Recombinant Protein (Rat) |
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| RP198320 | ABM | 100 ug | Ask for price |
DNAJB9 Recombinant Protein (Rat) |
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| RP198323 | ABM | 100 ug | Ask for price |
DNAJC2 Recombinant Protein (Rat) |
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| RP198350 | ABM | 100 ug | Ask for price |
DNAJC3 Recombinant Protein (Rat) |
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| RP198371 | ABM | 100 ug | Ask for price |
DNAJC4 Recombinant Protein (Rat) |
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| RP198377 | ABM | 100 ug | Ask for price |
DNAJC5 Recombinant Protein (Rat) |
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| RP198380 | ABM | 100 ug | Ask for price |
DNAJC7 Recombinant Protein (Rat) |
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| RP198392 | ABM | 100 ug | Ask for price |
DNAJC8 Recombinant Protein (Rat) |
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| RP198395 | ABM | 100 ug | Ask for price |
DNAJC9 Recombinant Protein (Rat) |
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| RP198398 | ABM | 100 ug | Ask for price |
DNALI1 Recombinant Protein (Rat) |
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| RP198407 | ABM | 100 ug | Ask for price |
DNASE1 Recombinant Protein (Rat) |
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| RP198410 | ABM | 100 ug | Ask for price |
Recombinant human DNA-binding protein inhibitor ID-1 |
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| P1872 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-binding protein inhibitor ID-1 |
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TARDBP TAR DNA Binding Protein Human Recombinant Protein |
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| PROTQ13148 | BosterBio | Regular: 10ug | EUR 380.4 |
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Description: TARDBP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 296 amino acids (1-260 a.a) and having a molecular mass of 33.6kDa. TARDBP is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
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Recombinant human DNA-directed RNA polymerase, mitochondrial |
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| P2352 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-directed RNA polymerase, mitochondrial |
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Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT) |
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| 4-RPC027Hu01 | Cloud-Clone |
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Description: Recombinant Human O-6-Methylguanine DNA Methyltransferase expressed in: E.coli |
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Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT) |
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| 4-RPC027Ra01 | Cloud-Clone |
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Description: Recombinant Rat O-6-Methylguanine DNA Methyltransferase expressed in: E.coli |
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Recombinant Human DNA ligase 1 Protein, GST, E.coli-1mg |
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| QP6308-ec-1mg | EnQuireBio | 1mg | EUR 1958.4 |
DNAJB11 Recombinant Protein (Rat) |
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| RP198290 | ABM | 100 ug | Ask for price |
DNAJB12 Recombinant Protein (Rat) |
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| RP198293 | ABM | 100 ug | Ask for price |
DNAJB13 Recombinant Protein (Rat) |
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| RP198296 | ABM | 100 ug | Ask for price |
DNAJB14 Recombinant Protein (Rat) |
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| RP198299 | ABM | 100 ug | Ask for price |
DNAJC10 Recombinant Protein (Rat) |
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| RP198326 | ABM | 100 ug | Ask for price |
DNAJC11 Recombinant Protein (Rat) |
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| RP198329 | ABM | 100 ug | Ask for price |
DNAJC12 Recombinant Protein (Rat) |
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| RP198332 | ABM | 100 ug | Ask for price |
DNAJC14 Recombinant Protein (Rat) |
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| RP198335 | ABM | 100 ug | Ask for price |
DNAJC15 Recombinant Protein (Rat) |
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| RP198338 | ABM | 100 ug | Ask for price |
Haplogroup evaluation means that mtDNA haplogroup H2a2a1 has potential contribution within the pathobiology of HAPE in lowlanders. This research suggests contribution of altered mitochondrial features in HAPE susceptibility.
