H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
Most cancers is likely one of the ailments that threatens human well being and is a number one reason behind mortality worldwide. Excessive ranges of reactive oxygen species (ROS) have been noticed in most cancers tissues in contrast with regular tissues in vivo, and it’s not but recognized how this influences chemotherapeutic drug motion. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer utilized in photodynamic remedy (PDT) and a telomerase inhibitor used within the remedy of telomerase-positive most cancers.
Right here, we investigated the anticancer exercise of TMPyP4 in A549 and PANC cells cultured in H2O2. The outcomes confirmed that in comparison with TMPyP4 alone, the mix of TMPyP4 and H2O2 exhibited sensitization results on cell viability and colony formation inhibition and apoptosis in A549 and PANC cells, however had no impact in human regular MIHA cells.
Mechanistically, the mix of TMPyP4 and H2O2 prompts excessive ROS and mitochondrial membrane potential in A549 and PANC cells, leading to intense DNA harm and DNA harm responses. Consequently, in comparison with TMPyP4 alone, TMPyP4 and H2O2 mixed remedy upregulates the expression of BAX, cleaved caspase 3, and p-JNK and downregulates the expression of Bcl-2 in A549 and PANC cells. Taken collectively, these knowledge prompt that H2O2 enhanced the anticancer exercise of TMPyP4-mediated ROS-dependent DNA harm and associated apoptotic protein regulation, revealing that the excessive ROS tumor microenvironment performs an vital position in chemotherapeutic drug motion.
Survival of an launched ectomycorrhizal Laccaria bicolor pressure in a European forest plantation monitored by mitochondrial ribosomal DNA evaluation
Mitochondrial and nuclear genes have totally different inheritance, thus research of fungal populations ought to use each mitochondrial and nuclear markers. Utilizing nuclear markers, the S238N pressure of the ectomycorrhizal basidiomycete Laccaria bicolor ((Maire) Orton) has been beforehand proven to persist for a minimum of 10 yr after outplanting in a plantation of Douglas fir (Pseudotsuga menziesii (Mir.) Franco) inoculated with this pressure. Within the current research, we’ve got sampled 539 sporophores of Laccaria spp. from this plantation, a few of which had the S238N nuclear genotype, to review mitochondrial DNA polymorphism and persistence of the inoculated S238N mitochondrial genome.
Size polymorphism in fragments of the big subunit of mitochondrial ribosomal DNA (LrDNA) allowed distinction of the haplotypes current within the plantation on the species stage. As well as, heteroduplex evaluation and sequencing revealed intraspecific polymorphism of LrDNA among the many L. bicolor sporophores and enabled particular identification of S238N LrDNA. This haplotype was solely retained in sporophores carrying the S238N nuclear genome, confirming the survival of this launched pressure in a pure inhabitants.
Bioallethrin enhances technology of ROS, damages DNA, impairs the redox system and causes mitochondrial dysfunction in human lymphocytes
Bioallethrin is an artificial pesticide that’s extensively used to manage insect pests. The broad use of bioallethrin has resulted in inevitable human publicity. On this research we report the impact of various concentrations of bioallethrin (10 to 200 µM, 2 h at 37 °C) on human lymphocytes underneath in vitro circumstances. Bioallethrin remedy resulted in lack of cell viability (> 30% at 200 µM bioallethrin). Oxidative stress markers like lipid peroxidation and protein oxidation have been considerably elevated accompanied by decrease ratio of decreased to oxidized glutathione.
Enhanced ROS technology was noticed by way of fluorescence spectroscopy and microscopy. Bioallethrin-induced oxidative stress additionally compromised the antioxidant defence because it decreased antioxidant capability of cells and inhibited main antioxidant enzymes. Biomolecular modifications and systemic toxicity by bioallethrin resulted in plasma membrane harm with mitochondrial depolarization.
Comet assay confirmed nuclear DNA fragmentation and strand scission with vital enhance in tail size and olive tail second. Apoptosis and necrosis of cells was confirmed by way of acridine orange/ethidium bromide twin staining and visualization underneath fluorescence microscope. Thus, bioallethrin causes oxidative harm and compromises the antioxidant system resulting in DNA harm, mobile and organelle toxicity, leading to apoptosis and necrosis of human lymphocytes.
Unearthing Neanderthal inhabitants historical past utilizing nuclear and mitochondrial DNA from cave sediments
Bones and enamel are vital sources of Pleistocene hominin DNA, however are hardly ever recovered at archaeological websites. Mitochondrial DNA has been retrieved from cave sediments, however offers restricted worth for learning inhabitants relationships. We due to this fact developed strategies for the enrichment and evaluation of nuclear DNA from sediments, and utilized them to cave deposits in western Europe and southern Siberia dated to between roughly 200,000 and 50,000 years in the past.
We detect a inhabitants substitute in northern Spain roughly 100,000 years in the past, accompanied by a turnover of mitochondrial DNA. We additionally establish two radiation occasions in Neanderthal historical past through the early a part of the Late Pleistocene. Our work lays the bottom for learning the inhabitants historical past of historical hominins from hint quantities of nuclear DNA in sediments.
Mitochondrial DNA mutations contribute to excessive altitude pulmonary edema by way of elevated oxidative stress and metabolic reprogramming throughout hypobaric hypoxia
Excessive altitude pulmonary edema (HAPE) is skilled by non-acclimatized sea stage people on publicity to excessive altitude hypoxic circumstances. Obtainable proof means that genetic elements and perturbed mitochondrial redox standing could play an vital position in HAPE pathophysiology. Nevertheless, the exact mechanism has not been absolutely understood.
Within the current research, sequencing of mitochondrial DNA (mtDNA) from HAPE topics and acclimatized controls was carried out to establish pathogenic mutations and to find out their position in HAPE. Hypobaric hypoxia induced oxidative stress and metabolic alterations have been additionally assessed in HAPE topics. mtDNA copy quantity, mitochondrial oxidative phosphorylation (mtOXPHOS) exercise, mitochondrial biogenesis have been measured to find out mitochondrial features.
The information revealed that the mutations in Advanced I genes impacts the secondary construction of protein in HAPE topics. Additional, elevated oxidative stress throughout hypobaric hypoxia, decreased mitochondrial biogenesis and mtOXPHOS exercise induced metabolic reprogramming which may contribute to mitochondrial dysfunctions in HAPE people.
Recombinant Rat DNA polymerase beta (Polb) |
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| MBS968051-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1140 |
Recombinant Rat DNA topoisomerase 1 (Top1) |
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| MBS1472351-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1615 |
Recombinant Rat DNA topoisomerase 1 (Top1) |
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| MBS1472351-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1350 |
Recombinant Rat DNA topoisomerase 1 (Top1) |
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| MBS1472351-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1370 |
Recombinant Rat DNA topoisomerase 1 (Top1) |
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| MBS1472351-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1630 |
Recombinant Rat DNA topoisomerase 1 (Top1) |
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| MBS1472351-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1615 |
Recombinant Rat DNA polymerase lambda (Poll) |
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| MBS1354670-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1435 |
Recombinant Rat DNA polymerase lambda (Poll) |
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| MBS1354670-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1125 |
Recombinant Rat DNA polymerase lambda (Poll) |
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| MBS1354670-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1195 |
Recombinant Rat DNA polymerase lambda (Poll) |
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| MBS1354670-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1350 |
Recombinant Rat DNA polymerase lambda (Poll) |
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| MBS1354670-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1400 |
Recombinant Rat DNA ligase 1 (Lig1) , partial |
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| MBS1300869-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA-3-methyladenine glycosylase (Mpg) |
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| MBS961429-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1195 |
Recombinant Rat DNA-3-methyladenine glycosylase (Mpg) |
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| MBS961429-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 845 |
Recombinant Rat DNA-3-methyladenine glycosylase (Mpg) |
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| MBS961429-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 985 |
Recombinant Rat DNA-3-methyladenine glycosylase (Mpg) |
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| MBS961429-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1015 |
Recombinant Rat DNA-3-methyladenine glycosylase (Mpg) |
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| MBS961429-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1120 |
Recombinant Rat DNA-binding protein A (Csda) |
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| MBS1281882-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1235 |
Recombinant Rat DNA-binding protein A (Csda) |
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| MBS1281882-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 895 |
Recombinant Rat DNA-binding protein A (Csda) |
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| MBS1281882-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1025 |
Recombinant Rat DNA-binding protein A (Csda) |
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| MBS1281882-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1075 |
Recombinant Rat DNA-binding protein A (Csda) |
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| MBS1281882-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1165 |
Recombinant Rat DNA repair protein XRCC1 (Xrcc1) |
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| MBS1447175-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1485 |
Recombinant Rat DNA repair protein XRCC1 (Xrcc1) |
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| MBS1447175-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1190 |
Recombinant Rat DNA repair protein XRCC1 (Xrcc1) |
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| MBS1447175-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1250 |
Recombinant Rat DNA repair protein XRCC1 (Xrcc1) |
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| MBS1447175-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1435 |
Recombinant Rat DNA repair protein XRCC1 (Xrcc1) |
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| MBS1447175-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1465 |
Recombinant Rat DNA-binding protein RFX2 (Rfx2) |
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| MBS1132719-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1545 |
Recombinant Rat DNA-binding protein RFX2 (Rfx2) |
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| MBS1132719-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1265 |
Recombinant Rat DNA-binding protein RFX2 (Rfx2) |
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| MBS1132719-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1305 |
Recombinant Rat DNA-binding protein RFX2 (Rfx2) |
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| MBS1132719-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1525 |
Recombinant Rat DNA-binding protein RFX2 (Rfx2) |
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| MBS1132719-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1530 |
Recombinant Rat DNA primase large subunit (Prim2) |
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| MBS1257617-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1370 |
Recombinant Rat DNA primase large subunit (Prim2) |
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| MBS1257617-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1075 |
Recombinant Rat DNA primase large subunit (Prim2) |
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| MBS1257617-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1130 |
Recombinant Rat DNA primase large subunit (Prim2) |
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| MBS1257617-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1255 |
Recombinant Rat DNA primase large subunit (Prim2) |
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| MBS1257617-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1330 |
Recombinant Rat N-glycosylase/DNA lyase (Ogg1) |
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| MBS1181339-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1220 |
Recombinant Rat N-glycosylase/DNA lyase (Ogg1) |
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| MBS1181339-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 880 |
Recombinant Rat N-glycosylase/DNA lyase (Ogg1) |
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| MBS1181339-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1010 |
Recombinant Rat N-glycosylase/DNA lyase (Ogg1) |
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| MBS1181339-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1055 |
Recombinant Rat N-glycosylase/DNA lyase (Ogg1) |
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| MBS1181339-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1150 |
Recombinant Rat DNA topoisomerase I, mitochondrial (Top1mt) |
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| MBS1327711-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1410 |
Recombinant Rat DNA topoisomerase I, mitochondrial (Top1mt) |
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| MBS1327711-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1130 |
Recombinant Rat DNA topoisomerase I, mitochondrial (Top1mt) |
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| MBS1327711-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1170 |
Recombinant Rat DNA topoisomerase I, mitochondrial (Top1mt) |
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| MBS1327711-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1320 |
Recombinant Rat DNA topoisomerase I, mitochondrial (Top1mt) |
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| MBS1327711-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1375 |
Recombinant Rat DNA repair protein SWI5 homolog (Swi5) |
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| MBS1350430-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1015 |
Recombinant Rat DNA repair protein SWI5 homolog (Swi5) |
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| MBS1350430-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 580 |
Recombinant Rat DNA repair protein SWI5 homolog (Swi5) |
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| MBS1350430-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 765 |
Recombinant Rat DNA repair protein SWI5 homolog (Swi5) |
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| MBS1350430-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 695 |
Recombinant Rat DNA repair protein SWI5 homolog (Swi5) |
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| MBS1350430-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 895 |
Recombinant Rat DNA polymerase alpha subunit B (Pola2) |
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| MBS1216567-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1460 |
Recombinant Rat DNA polymerase alpha subunit B (Pola2) |
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| MBS1216567-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1155 |
Recombinant Rat DNA polymerase alpha subunit B (Pola2) |
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| MBS1216567-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1220 |
Recombinant Rat DNA polymerase alpha subunit B (Pola2) |
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| MBS1216567-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1390 |
Recombinant Rat DNA polymerase alpha subunit B (Pola2) |
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| MBS1216567-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1430 |
Recombinant Rat DNA polymerase delta subunit 2 (Pold2) |
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| MBS1347113-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1335 |
Recombinant Rat DNA polymerase delta subunit 2 (Pold2) |
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| MBS1347113-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1030 |
Recombinant Rat DNA polymerase delta subunit 2 (Pold2) |
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| MBS1347113-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1130 |
Recombinant Rat DNA polymerase delta subunit 2 (Pold2) |
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| MBS1347113-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1200 |
Recombinant Rat DNA polymerase delta subunit 2 (Pold2) |
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| MBS1347113-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1285 |
Recombinant Rat DNA mismatch repair protein Mlh1 (Mlh1) |
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| MBS966407-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1605 |
Recombinant Rat DNA mismatch repair protein Mlh1 (Mlh1) |
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| MBS966407-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1340 |
Recombinant Rat DNA mismatch repair protein Mlh1 (Mlh1) |
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| MBS966407-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1365 |
Recombinant Rat DNA mismatch repair protein Mlh1 (Mlh1) |
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| MBS966407-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1615 |
Recombinant Rat DNA mismatch repair protein Mlh1 (Mlh1) |
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| MBS966407-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1605 |
Recombinant Rat DNA repair protein RAD50 (Rad50) , partial |
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| MBS1386358-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA polymerase epsilon subunit 3 (Pole3) |
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| MBS1360335-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1065 |
Recombinant Rat DNA polymerase epsilon subunit 3 (Pole3) |
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| MBS1360335-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 650 |
Recombinant Rat DNA polymerase epsilon subunit 3 (Pole3) |
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| MBS1360335-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 820 |
Recombinant Rat DNA polymerase epsilon subunit 3 (Pole3) |
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| MBS1360335-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 755 |
Recombinant Rat DNA polymerase epsilon subunit 3 (Pole3) |
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| MBS1360335-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 960 |
Recombinant Rat DNA topoisomerase 2-alpha (Top2a) , partial |
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| MBS953442-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA replication licensing factor MCM6 (Mcm6) |
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| MBS1404294-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1370 |
Recombinant Rat DNA replication licensing factor MCM6 (Mcm6) |
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| MBS1404294-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1075 |
Recombinant Rat DNA replication licensing factor MCM6 (Mcm6) |
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| MBS1404294-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1130 |
Recombinant Rat DNA replication licensing factor MCM6 (Mcm6) |
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| MBS1404294-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1255 |
Recombinant Rat DNA replication licensing factor MCM6 (Mcm6) |
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| MBS1404294-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1330 |
Recombinant Rat DNA fragmentation factor subunit beta (Dffb) |
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| MBS1405486-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1225 |
Recombinant Rat DNA fragmentation factor subunit beta (Dffb) |
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| MBS1405486-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 880 |
Recombinant Rat DNA fragmentation factor subunit beta (Dffb) |
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| MBS1405486-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1015 |
Recombinant Rat DNA fragmentation factor subunit beta (Dffb) |
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| MBS1405486-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1060 |
Recombinant Rat DNA fragmentation factor subunit beta (Dffb) |
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| MBS1405486-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1155 |
Recombinant Rat cytomegalovirus DNA polymerase (UL54), partial |
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| MBS1312159-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat ATP-dependent DNA helicase Q1 (Recql) |
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| MBS1337961-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1480 |
Recombinant Rat ATP-dependent DNA helicase Q1 (Recql) |
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| MBS1337961-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1180 |
Recombinant Rat ATP-dependent DNA helicase Q1 (Recql) |
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| MBS1337961-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1240 |
Recombinant Rat ATP-dependent DNA helicase Q1 (Recql) |
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| MBS1337961-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1420 |
Recombinant Rat ATP-dependent DNA helicase Q1 (Recql) |
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| MBS1337961-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1455 |
Recombinant Rat ATP-dependent DNA helicase PIF1 (Pif1) |
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| MBS1455378-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1490 |
Recombinant Rat ATP-dependent DNA helicase PIF1 (Pif1) |
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| MBS1455378-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1195 |
Recombinant Rat ATP-dependent DNA helicase PIF1 (Pif1) |
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| MBS1455378-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1250 |
Recombinant Rat ATP-dependent DNA helicase PIF1 (Pif1) |
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| MBS1455378-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1440 |
Recombinant Rat ATP-dependent DNA helicase PIF1 (Pif1) |
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| MBS1455378-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1465 |
Recombinant Rat DNA-binding protein inhibitor ID-3 (Id3) |
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| MBS954946-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1040 |
Recombinant Rat DNA-binding protein inhibitor ID-3 (Id3) |
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| MBS954946-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 620 |
Recombinant Rat DNA-binding protein inhibitor ID-3 (Id3) |
|||
| MBS954946-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 795 |
Recombinant Rat DNA-binding protein inhibitor ID-3 (Id3) |
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| MBS954946-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 720 |
Recombinant Rat DNA-binding protein inhibitor ID-3 (Id3) |
|||
| MBS954946-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 930 |
Recombinant Rat DNA-binding protein inhibitor ID-2 (Id2) |
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| MBS951961-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1055 |
Recombinant Rat DNA-binding protein inhibitor ID-2 (Id2) |
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| MBS951961-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 640 |
Recombinant Rat DNA-binding protein inhibitor ID-2 (Id2) |
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| MBS951961-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 810 |
Recombinant Rat DNA-binding protein inhibitor ID-2 (Id2) |
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| MBS951961-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 745 |
Recombinant Rat DNA-binding protein inhibitor ID-2 (Id2) |
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| MBS951961-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 945 |
Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1) |
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| MBS960727-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1085 |
Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1) |
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| MBS960727-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 675 |
Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1) |
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| MBS960727-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 840 |
Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1) |
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| MBS960727-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 785 |
Recombinant Rat DNA-binding protein inhibitor ID-1 (Id1) |
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| MBS960727-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 980 |
Recombinant Rat DNA damage-binding protein 1 (Ddb1) , partial |
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| MBS1325384-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA polymerase subunit gamma-1 (Polg) , partial |
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| MBS1298236-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA- (apurinic or apyrimidinic site) lyase (Apex1) |
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| MBS959810-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1195 |
Recombinant Rat DNA- (apurinic or apyrimidinic site) lyase (Apex1) |
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| MBS959810-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 845 |
Recombinant Rat DNA- (apurinic or apyrimidinic site) lyase (Apex1) |
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| MBS959810-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 985 |
Recombinant Rat DNA- (apurinic or apyrimidinic site) lyase (Apex1) |
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| MBS959810-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1015 |
Recombinant Rat DNA- (apurinic or apyrimidinic site) lyase (Apex1) |
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| MBS959810-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1120 |
Recombinant Rat DNA mismatch repair protein Msh2 (Msh2) , partial |
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| MBS965586-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA replication complex GINS protein SLD5 (Gins4) |
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| MBS1448178-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1140 |
Recombinant Rat DNA replication complex GINS protein SLD5 (Gins4) |
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| MBS1448178-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 730 |
Recombinant Rat DNA replication complex GINS protein SLD5 (Gins4) |
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| MBS1448178-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 895 |
Recombinant Rat DNA replication complex GINS protein SLD5 (Gins4) |
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| MBS1448178-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 875 |
Recombinant Rat DNA replication complex GINS protein SLD5 (Gins4) |
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| MBS1448178-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1045 |
Recombinant Rat DNA-binding protein SMUBP-2 (Ighmbp2) , partial |
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| MBS1416390-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA damage-inducible transcript 4 protein (Ddit4) |
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| MBS1450732-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1120 |
Recombinant Rat DNA damage-inducible transcript 4 protein (Ddit4) |
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| MBS1450732-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 735 |
Recombinant Rat DNA damage-inducible transcript 4 protein (Ddit4) |
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| MBS1450732-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 900 |
Recombinant Rat DNA damage-inducible transcript 4 protein (Ddit4) |
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| MBS1450732-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 885 |
Recombinant Rat DNA damage-inducible transcript 4 protein (Ddit4) |
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| MBS1450732-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1055 |
Recombinant Rat DNA (cytosine-5)-methyltransferase 3-like (Dnmt3l) |
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| MBS1364918-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1290 |
Recombinant Rat DNA (cytosine-5)-methyltransferase 3-like (Dnmt3l) |
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| MBS1364918-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 970 |
Recombinant Rat DNA (cytosine-5)-methyltransferase 3-like (Dnmt3l) |
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| MBS1364918-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1085 |
Recombinant Rat DNA (cytosine-5)-methyltransferase 3-like (Dnmt3l) |
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| MBS1364918-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1135 |
Recombinant Rat DNA (cytosine-5)-methyltransferase 3-like (Dnmt3l) |
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| MBS1364918-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1235 |
Recombinant Rat DNA damage-inducible transcript 3 protein (Ddit3) |
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| MBS1325261-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1090 |
Recombinant Rat DNA damage-inducible transcript 3 protein (Ddit3) |
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| MBS1325261-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 680 |
Recombinant Rat DNA damage-inducible transcript 3 protein (Ddit3) |
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| MBS1325261-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 840 |
Recombinant Rat DNA damage-inducible transcript 3 protein (Ddit3) |
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| MBS1325261-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 795 |
Recombinant Rat DNA damage-inducible transcript 3 protein (Ddit3) |
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| MBS1325261-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 985 |
Recombinant Rat DNA polymerase delta catalytic subunit (Pold1) , partial |
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| MBS1018697-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA polymerase alpha catalytic subunit (Pola1) , partial |
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| MBS1041211-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) , partial |
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| MBS1377345-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Rat A/G-specific adenine DNA glycosylase (Mutyh) |
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| MBS1415521-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1380 |
Recombinant Rat A/G-specific adenine DNA glycosylase (Mutyh) |
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| MBS1415521-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 1085 |
Recombinant Rat A/G-specific adenine DNA glycosylase (Mutyh) |
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| MBS1415521-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1140 |
Recombinant Rat A/G-specific adenine DNA glycosylase (Mutyh) |
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| MBS1415521-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1270 |
Recombinant Rat A/G-specific adenine DNA glycosylase (Mutyh) |
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| MBS1415521-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1340 |
Recombinant Rat Single-stranded DNA-binding protein 3 (Ssbp3) |
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| MBS1427462-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1235 |
Recombinant Rat Single-stranded DNA-binding protein 3 (Ssbp3) |
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| MBS1427462-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 900 |
Recombinant Rat Single-stranded DNA-binding protein 3 (Ssbp3) |
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| MBS1427462-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 1025 |
Recombinant Rat Single-stranded DNA-binding protein 3 (Ssbp3) |
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| MBS1427462-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1080 |
Recombinant Rat Single-stranded DNA-binding protein 3 (Ssbp3) |
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| MBS1427462-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1170 |
Recombinant Rat DNA-directed RNA polymerase III subunit RPC9 (Crcp) |
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| MBS1449574-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1070 |
Recombinant Rat DNA-directed RNA polymerase III subunit RPC9 (Crcp) |
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| MBS1449574-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 655 |
Recombinant Rat DNA-directed RNA polymerase III subunit RPC9 (Crcp) |
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| MBS1449574-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 825 |
Recombinant Rat DNA-directed RNA polymerase III subunit RPC9 (Crcp) |
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| MBS1449574-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 765 |
Recombinant Rat DNA-directed RNA polymerase III subunit RPC9 (Crcp) |
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| MBS1449574-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 965 |
Recombinant Rat DNA-directed RNA polymerase I subunit RPA12 (Znrd1) |
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| MBS1280767-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1045 |
Recombinant Rat DNA-directed RNA polymerase I subunit RPA12 (Znrd1) |
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| MBS1280767-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 625 |
Recombinant Rat DNA-directed RNA polymerase I subunit RPA12 (Znrd1) |
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| MBS1280767-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 800 |
Recombinant Rat DNA-directed RNA polymerase I subunit RPA12 (Znrd1) |
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| MBS1280767-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 725 |
Recombinant Rat DNA-directed RNA polymerase I subunit RPA12 (Znrd1) |
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| MBS1280767-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 935 |
Recombinant Rat DNA-directed RNA polymerase II subunit RPB7 (Polr2g) |
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| MBS966602-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1095 |
Recombinant Rat DNA-directed RNA polymerase II subunit RPB7 (Polr2g) |
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| MBS966602-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 685 |
Recombinant Rat DNA-directed RNA polymerase II subunit RPB7 (Polr2g) |
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| MBS966602-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 845 |
Recombinant Rat DNA-directed RNA polymerase II subunit RPB7 (Polr2g) |
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| MBS966602-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 800 |
Haplogroup evaluation means that mtDNA haplogroup H2a2a1 has potential contribution within the pathobiology of HAPE in lowlanders. This research suggests contribution of altered mitochondrial features in HAPE susceptibility.
