H 2 O 2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage
Most cancers is likely one of the ailments that threatens human well being and is a number one reason behind mortality worldwide. Excessive ranges of reactive oxygen species (ROS) have been noticed in most cancers tissues in contrast with regular tissues in vivo, and it’s not but recognized how this influences chemotherapeutic drug motion. Cationic porphyrin 5,10,15,20-tetra-(N-methyl-4-pyridyl) porphyrin (TMPyP4) is a photosensitizer utilized in photodynamic remedy (PDT) and a telomerase inhibitor used within the remedy of telomerase-positive most cancers.
Right here, we investigated the anticancer exercise of TMPyP4 in A549 and PANC cells cultured in H2O2. The outcomes confirmed that in comparison with TMPyP4 alone, the mix of TMPyP4 and H2O2 exhibited sensitization results on cell viability and colony formation inhibition and apoptosis in A549 and PANC cells, however had no impact in human regular MIHA cells.
Mechanistically, the mix of TMPyP4 and H2O2 prompts excessive ROS and mitochondrial membrane potential in A549 and PANC cells, leading to intense DNA harm and DNA harm responses. Consequently, in comparison with TMPyP4 alone, TMPyP4 and H2O2 mixed remedy upregulates the expression of BAX, cleaved caspase 3, and p-JNK and downregulates the expression of Bcl-2 in A549 and PANC cells. Taken collectively, these knowledge prompt that H2O2 enhanced the anticancer exercise of TMPyP4-mediated ROS-dependent DNA harm and associated apoptotic protein regulation, revealing that the excessive ROS tumor microenvironment performs an vital position in chemotherapeutic drug motion.
Survival of an launched ectomycorrhizal Laccaria bicolor pressure in a European forest plantation monitored by mitochondrial ribosomal DNA evaluation
Mitochondrial and nuclear genes have totally different inheritance, thus research of fungal populations ought to use each mitochondrial and nuclear markers. Utilizing nuclear markers, the S238N pressure of the ectomycorrhizal basidiomycete Laccaria bicolor ((Maire) Orton) has been beforehand proven to persist for a minimum of 10 yr after outplanting in a plantation of Douglas fir (Pseudotsuga menziesii (Mir.) Franco) inoculated with this pressure. Within the current research, we’ve got sampled 539 sporophores of Laccaria spp. from this plantation, a few of which had the S238N nuclear genotype, to review mitochondrial DNA polymorphism and persistence of the inoculated S238N mitochondrial genome.
Size polymorphism in fragments of the big subunit of mitochondrial ribosomal DNA (LrDNA) allowed distinction of the haplotypes current within the plantation on the species stage. As well as, heteroduplex evaluation and sequencing revealed intraspecific polymorphism of LrDNA among the many L. bicolor sporophores and enabled particular identification of S238N LrDNA. This haplotype was solely retained in sporophores carrying the S238N nuclear genome, confirming the survival of this launched pressure in a pure inhabitants.
Bioallethrin enhances technology of ROS, damages DNA, impairs the redox system and causes mitochondrial dysfunction in human lymphocytes
Bioallethrin is an artificial pesticide that’s extensively used to manage insect pests. The broad use of bioallethrin has resulted in inevitable human publicity. On this research we report the impact of various concentrations of bioallethrin (10 to 200 µM, 2 h at 37 °C) on human lymphocytes underneath in vitro circumstances. Bioallethrin remedy resulted in lack of cell viability (> 30% at 200 µM bioallethrin). Oxidative stress markers like lipid peroxidation and protein oxidation have been considerably elevated accompanied by decrease ratio of decreased to oxidized glutathione.
Enhanced ROS technology was noticed by way of fluorescence spectroscopy and microscopy. Bioallethrin-induced oxidative stress additionally compromised the antioxidant defence because it decreased antioxidant capability of cells and inhibited main antioxidant enzymes. Biomolecular modifications and systemic toxicity by bioallethrin resulted in plasma membrane harm with mitochondrial depolarization.
Comet assay confirmed nuclear DNA fragmentation and strand scission with vital enhance in tail size and olive tail second. Apoptosis and necrosis of cells was confirmed by way of acridine orange/ethidium bromide twin staining and visualization underneath fluorescence microscope. Thus, bioallethrin causes oxidative harm and compromises the antioxidant system resulting in DNA harm, mobile and organelle toxicity, leading to apoptosis and necrosis of human lymphocytes.
Unearthing Neanderthal inhabitants historical past utilizing nuclear and mitochondrial DNA from cave sediments
Bones and enamel are vital sources of Pleistocene hominin DNA, however are hardly ever recovered at archaeological websites. Mitochondrial DNA has been retrieved from cave sediments, however offers restricted worth for learning inhabitants relationships. We due to this fact developed strategies for the enrichment and evaluation of nuclear DNA from sediments, and utilized them to cave deposits in western Europe and southern Siberia dated to between roughly 200,000 and 50,000 years in the past.
We detect a inhabitants substitute in northern Spain roughly 100,000 years in the past, accompanied by a turnover of mitochondrial DNA. We additionally establish two radiation occasions in Neanderthal historical past through the early a part of the Late Pleistocene. Our work lays the bottom for learning the inhabitants historical past of historical hominins from hint quantities of nuclear DNA in sediments.
Mitochondrial DNA mutations contribute to excessive altitude pulmonary edema by way of elevated oxidative stress and metabolic reprogramming throughout hypobaric hypoxia
Excessive altitude pulmonary edema (HAPE) is skilled by non-acclimatized sea stage people on publicity to excessive altitude hypoxic circumstances. Obtainable proof means that genetic elements and perturbed mitochondrial redox standing could play an vital position in HAPE pathophysiology. Nevertheless, the exact mechanism has not been absolutely understood.
Within the current research, sequencing of mitochondrial DNA (mtDNA) from HAPE topics and acclimatized controls was carried out to establish pathogenic mutations and to find out their position in HAPE. Hypobaric hypoxia induced oxidative stress and metabolic alterations have been additionally assessed in HAPE topics. mtDNA copy quantity, mitochondrial oxidative phosphorylation (mtOXPHOS) exercise, mitochondrial biogenesis have been measured to find out mitochondrial features.
The information revealed that the mutations in Advanced I genes impacts the secondary construction of protein in HAPE topics. Additional, elevated oxidative stress throughout hypobaric hypoxia, decreased mitochondrial biogenesis and mtOXPHOS exercise induced metabolic reprogramming which may contribute to mitochondrial dysfunctions in HAPE people.
) Thymine-DNA Glycosylase (Recombinant) |
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| 20-abx073364 | Abbexa |
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) Taq DNA Polymerase (Recombinant) |
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| abx073521-10000U | Abbexa | 10000 U | EUR 592 |
Taq DNA Polymerase (Recombinant) |
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| abx073521-1000U | Abbexa | 1000 U | EUR 230 |
Taq DNA Polymerase (Recombinant) |
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| abx073521-3000U | Abbexa | 3000 U | EUR 328 |
) DNA Topoisomerase-I (Recombinant) |
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| 20-abx073616 | Abbexa |
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) Pfu DNA Polymerase (Recombinant) |
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| abx074017-100U | Abbexa | 100 U | EUR 328 |
Pfu DNA Polymerase (Recombinant) |
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| abx074017-2500U | Abbexa | 2500 U | EUR 1274 |
Pfu DNA Polymerase (Recombinant) |
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| abx074017-500U | Abbexa | 500 U | EUR 439 |
 Recombinant T4 DNA Ligase |
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| 7-03622 | CHI Scientific | 20,000IU | Ask for price |
Recombinant T4 DNA Ligase |
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| 7-03623 | CHI Scientific | 100,000IU | Ask for price |
Recombinant T4 DNA Ligase |
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| 7-03624 | CHI Scientific | 500,000IU | Ask for price |
 Recombinant Taq DNA Polymerase |
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| 7-03634 | CHI Scientific | 1,000U | Ask for price |
Recombinant Taq DNA Polymerase |
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| 7-03635 | CHI Scientific | 3,000U | Ask for price |
Recombinant Taq DNA Polymerase |
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| 7-03636 | CHI Scientific | 10,000U | Ask for price |
 Recombinant Pfu DNA Polymerase |
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| 7-03322 | CHI Scientific | 100U | Ask for price |
Recombinant Pfu DNA Polymerase |
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| 7-03323 | CHI Scientific | 500U | Ask for price |
Recombinant Pfu DNA Polymerase |
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| 7-03324 | CHI Scientific | 2500U | Ask for price |
 Recombinant human DNA-directed DNA/RNA polymerase mu |
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| P2815 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-directed DNA/RNA polymerase mu |
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 DNA-PKcs recombinant monoclonal antibody |
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| A5876 | Bimake | 100ul X 3 | EUR 595 |
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Description: A recombinant monoclonal antibody from rabbit against human DNA-PKcs for WB, IHC,ELISA |
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) Recombinant DNA Methyltransferase 1 (DNMT1) |
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| 4-RPJ244Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Methyltransferase 1 expressed in: E.coli |
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) Recombinant DNA Methyltransferase 3B (DNMT3B) |
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| 4-RPJ246Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Methyltransferase 3B expressed in: E.coli |
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) Recombinant Uracil DNA Glycosylase (UNG) |
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| 4-RPG917Hu01 | Cloud-Clone |
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Description: Recombinant Human Uracil DNA Glycosylase expressed in: E.coli |
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, beta (Recombinant)) Polymerase (DNA directed), beta (Recombinant) |
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| 20-abx073237 | Abbexa |
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) 8-Oxoguanine DNA Glycosylase (Recombinant) |
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| 20-abx073274 | Abbexa |
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) Taq Plus DNA Polymerase (Recombinant) |
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| abx073522-2500U | Abbexa | 2.500 U | EUR 592 |
Taq Plus DNA Polymerase (Recombinant) |
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| abx073522-250U | Abbexa | 250 U | EUR 230 |
Taq Plus DNA Polymerase (Recombinant) |
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| abx073522-750U | Abbexa | 750 U | EUR 328 |
) N-Methylpurine-DNA Glycosylase (Recombinant) |
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| 20-abx073622 | Abbexa |
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, lambda (Recombinant)) Polymerase (DNA directed), lambda (Recombinant) |
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| 20-abx073724 | Abbexa |
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) E.Coli Formamidopyrimidine-DNA Glycosylase (Recombinant) |
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| 20-abx073795 | Abbexa |
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) Tyrosyl-DNA Phosphodiesterase 2 (Recombinant) |
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| 20-abx073819 | Abbexa |
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) E.Coli Adenine DNA Glycosylase (Recombinant) |
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| 20-abx074009 | Abbexa |
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 Recombinant Taq Plus DNA Polymerase |
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| 7-03631 | CHI Scientific | 250U | Ask for price |
Recombinant Taq Plus DNA Polymerase |
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| 7-03632 | CHI Scientific | 750U | Ask for price |
Recombinant Taq Plus DNA Polymerase |
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| 7-03633 | CHI Scientific | 2,500U | Ask for price |
 Recombinant Human DNA Topoisomerase-I |
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| 7-03658 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Topoisomerase-I |
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| 7-03659 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Topoisomerase-I |
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| 7-03660 | CHI Scientific | 1mg | Ask for price |
 T4 DNA Ligase) Recombinant (E.Coli) T4 DNA Ligase |
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| RP-374 | Alpha Diagnostics | 20 KU | EUR 164 |
 Taq DNA Polymerase) Recombinant (E.Coli) Taq DNA Polymerase |
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| RP-394 | Alpha Diagnostics | 1000 IU | EUR 164 |
 Genomic DNA - Rat Male |
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| D1434999-G01 | Biochain | 100 ug | EUR 188 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Genomic DNA - Rat Female |
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| D1434999-G02 | Biochain | 100 ug | EUR 188 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 Rat Methylated DNA Control |
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| D6434149 | Biochain | 5 ug | Ask for price |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
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 n-DNA-Ab/ Rat n- DNA- Ab ELISA Kit |
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| ELA-E1126r | Lifescience Market | 96 Tests | EUR 886 |
 DNA Ligase IV recombinant monoclonal antibody |
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| A5820 | Bimake | 100ul X 3 | EUR 595 |
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Description: A recombinant monoclonal antibody from rabbit against human DNA Ligase IV for WB, IHC, IF,ELISA |
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 DNA Polymerase beta recombinant monoclonal antibody |
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| A5473 | Bimake | 100ul X 3 | EUR 595 |
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Description: A recombinant monoclonal antibody from rabbit against human DNA Polymerase beta for WB,ELISA |
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) Recombinant DNA Repair Protein RAD50 (RAD50) |
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| 4-RPK111Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
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Recombinant DNA Repair Protein RAD50 (RAD50) |
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| 4-RPK111Hu02 | Cloud-Clone |
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Description: Recombinant Human DNA Repair Protein RAD50 expressed in: E.coli |
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Recombinant DNA Repair Protein RAD50 (RAD50) |
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| 4-RPK111Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Repair Protein RAD50 expressed in: E.coli |
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) Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) |
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| 4-RPC785Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli |
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Recombinant Tyrosyl DNA Phosphodiesterase 1 (TDP1) |
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| 4-RPC785Ra01 | Cloud-Clone |
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Description: Recombinant Rat Tyrosyl DNA Phosphodiesterase 1 expressed in: E.coli |
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) Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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| 4-RPH625Hu01 | Cloud-Clone |
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Description: Recombinant Human N-Methylpurine DNA Glycosylase expressed in: E.coli |
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Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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| 4-RPH625Mu01 | Cloud-Clone |
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Description: Recombinant Mouse N-Methylpurine DNA Glycosylase expressed in: E.coli |
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Recombinant N-Methylpurine DNA Glycosylase (MPG) |
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| 4-RPH625Ra01 | Cloud-Clone |
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Description: Recombinant Rat N-Methylpurine DNA Glycosylase expressed in: E.coli |
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) O-6-Methylguanine-DNA Methyltransferase (Recombinant) |
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| 20-abx073555 | Abbexa |
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) DNA Topoisomerase-I 70 kDa (Recombinant) |
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| 20-abx073615 | Abbexa |
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 Recombinant Human DNA Topoisomerase-I 70kDa |
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| 7-03661 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Topoisomerase-I 70kDa |
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| 7-03662 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Topoisomerase-I 70kDa |
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| 7-03663 | CHI Scientific | 1mg | Ask for price |
 Recombinant Human N-Methylpurine-DNA Glycosylase |
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| 7-03169 | CHI Scientific | 2µg | Ask for price |
Recombinant Human N-Methylpurine-DNA Glycosylase |
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| 7-03170 | CHI Scientific | 10µg | Ask for price |
Recombinant Human N-Methylpurine-DNA Glycosylase |
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| 7-03171 | CHI Scientific | 1mg | Ask for price |
 Recombinant Human 8-Oxoguanine DNA Glycosylase |
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| 7-03277 | CHI Scientific | 5µg | Ask for price |
Recombinant Human 8-Oxoguanine DNA Glycosylase |
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| 7-03278 | CHI Scientific | 20µg | Ask for price |
Recombinant Human 8-Oxoguanine DNA Glycosylase |
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| 7-03279 | CHI Scientific | 1mg | Ask for price |
 TOP1 DNA Topoisomerase-IHuman Recombinant Protein |
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| PROTP11387-1 | BosterBio | Regular: 20ug | EUR 317 |
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Description: DNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 Dalton (excluding glycosilation) 102 kDa total mass. The TOP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. |
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 Recombinant human DNA repair protein REV1 |
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| P2230 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA repair protein REV1 |
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 Recombinant human DNA topoisomerase I, mitochondrial |
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| P2243 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA topoisomerase I, mitochondrial |
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 Recombinant human DNA-binding protein RFXANK |
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| P2771 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-binding protein RFXANK |
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 Recombinant human DNA-binding protein RFX2 |
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| P2855 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-binding protein RFX2 |
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 Taq Plus DNA Polymerase) Recombinant (E.Coli) Taq Plus DNA Polymerase |
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| RP-395 | Alpha Diagnostics | 250 U | EUR 164 |
 Rat Anti-DNA ELISA Kit |
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| ERD0216 | Abclonal | 96Tests | EUR 521 |
) Recombinant Human DNA Polymerase β (C-6His) |
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| C159-10ug | Novoprotein | 10ug | EUR 156 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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Recombinant Human DNA Polymerase β (C-6His) |
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| C159-1mg | Novoprotein | 1mg | EUR 2283 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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Recombinant Human DNA Polymerase β (C-6His) |
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| C159-500ug | Novoprotein | 500ug | EUR 1613 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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Recombinant Human DNA Polymerase β (C-6His) |
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| C159-50ug | Novoprotein | 50ug | EUR 369 |
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Description: Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. |
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) Recombinant Tar DNA Binding Protein 43kDa (TDP43) |
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| 4-RPB951Hu01 | Cloud-Clone |
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Description: Recombinant Human Tar DNA Binding Protein 43kDa expressed in: E.coli |
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Recombinant Tar DNA Binding Protein 43kDa (TDP43) |
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| 4-RPB951Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tar DNA Binding Protein 43kDa expressed in: E.coli |
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) Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT) |
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| 4-RPC027Hu01 | Cloud-Clone |
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Description: Recombinant Human O-6-Methylguanine DNA Methyltransferase expressed in: E.coli |
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Recombinant O-6-Methylguanine DNA Methyltransferase (MGMT) |
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| 4-RPC027Ra01 | Cloud-Clone |
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Description: Recombinant Rat O-6-Methylguanine DNA Methyltransferase expressed in: E.coli |
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) Recombinant ATP Dependent DNA ligase I (LIG1) |
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| 4-RPB269Hu01 | Cloud-Clone |
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Description: Recombinant Human ATP Dependent DNA ligase I expressed in: E.coli |
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Recombinant ATP Dependent DNA ligase I (LIG1) |
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| 4-RPB269Ra01 | Cloud-Clone |
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Description: Recombinant Rat ATP Dependent DNA ligase I expressed in: E.coli |
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) Recombinant DNA Damage Inducible Transcript 3 (DDIT3) |
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| 4-RPJ282Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Damage Inducible Transcript 3 expressed in: E.coli |
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Recombinant DNA Damage Inducible Transcript 3 (DDIT3) |
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| 4-RPJ282Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Damage Inducible Transcript 3 expressed in: E.coli |
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) Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa) |
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| 4-RPL426Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Fragmentation Factor Subunit Alpha expressed in: E.coli |
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Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa) |
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| 4-RPL426Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Fragmentation Factor Subunit Alpha expressed in: E.coli |
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) Recombinant Polymerase DNA Directed Alpha 1 (POLa1) |
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| 4-RPC713Hu01 | Cloud-Clone |
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Description: Recombinant Human Polymerase DNA Directed Alpha 1 expressed in: E.coli |
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Recombinant Polymerase DNA Directed Alpha 1 (POLa1) |
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| 4-RPC713Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Polymerase DNA Directed Alpha 1 expressed in: E.coli |
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) Recombinant Polymerase DNA Directed Delta 1 (POLd) |
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| 4-RPC717Hu01 | Cloud-Clone |
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Description: Recombinant Human Polymerase DNA Directed Delta 1 expressed in: E.coli |
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) Recombinant Polymerase DNA Directed Gamma 1 (POLg1) |
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| 4-RPF723Hu01 | Cloud-Clone |
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Description: Recombinant Human Polymerase DNA Directed Gamma 1 expressed in: E.coli |
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) Recombinant Z-DNA Binding Protein 1 (ZBP1) |
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| 4-RPB552Hu01 | Cloud-Clone |
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Description: Recombinant Human Z-DNA Binding Protein 1 expressed in: E.coli |
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 MUTM Formamidopyrimidine-DNA Glycosylase E.Coli Recombinant Protein |
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| PROTP05523 | BosterBio | Regular: 10ug | EUR 317 |
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Description: MUTM Recombinant produced in E. coli is a single polypeptide chain containing 289 amino acids (1-269) and having a molecular mass of 32.4kDa.;MUTM is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
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) DNA Cytosine-5--Methyltransferase 3-Like (Recombinant) |
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| 20-abx073992 | Abbexa |
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 Recombinant Human DNA Damage Inducible Transcript 3 |
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| 7-04969 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 3 |
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| 7-04970 | CHI Scientific | 20µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 3 |
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| 7-04971 | CHI Scientific | 1mg | Ask for price |
 Recombinant Human DNA Damage Inducible Transcript 4 |
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| 7-04972 | CHI Scientific | 2µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 4 |
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| 7-04973 | CHI Scientific | 10µg | Ask for price |
Recombinant Human DNA Damage Inducible Transcript 4 |
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| 7-04974 | CHI Scientific | 1mg | Ask for price |
 Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04978 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04979 | CHI Scientific | 25µg | Ask for price |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04980 | CHI Scientific | 1mg | Ask for price |
 Recombinant Human O-6-Methylguanine-DNA Methyltransferase |
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| 7-03133 | CHI Scientific | 5µg | Ask for price |
Recombinant Human O-6-Methylguanine-DNA Methyltransferase |
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| 7-03134 | CHI Scientific | 20µg | Ask for price |
Recombinant Human O-6-Methylguanine-DNA Methyltransferase |
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| 7-03135 | CHI Scientific | 1mg | Ask for price |
 Recombinant CMV ICP36 DNA Binding Protein [GST] |
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| VAng-Lsx0042-inquire | Creative Biolabs | inquire | Ask for price |
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Description: CMV ICP36 DNA Binding Protein [GST], recombinant protein from E. coli. |
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 UNG Uracil DNA Glycosylase E.Coli Recombinant Protein |
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| PROTP12295 | BosterBio | Regular: 10ug | EUR 317 |
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Description: UNG E.Coli Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229 a.a) and having a molecular mass of 28.1kDa. |
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 MutY Adenine DNA Glycosylase E.Coli Recombinant Protein |
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| PROTP17802 | BosterBio | Regular: 5ug | EUR 317 |
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Description: MutY Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 373 amino acids (1-350) and having a molecular mass of 41.5kDa. MutY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
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 TDG Thymine-DNA Glycosylase Human Recombinant Protein |
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| PROTQ13569 | BosterBio | Regular: 20ug | EUR 317 |
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Description: TDG Human Recombinant produced in E. coli is a single polypeptide chain containing 433 amino acids (1-410) and having a molecular mass of 48.4 kDa.;TDG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
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 Recombinant human DNA-directed RNA polymerase, mitochondrial |
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| P2352 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-directed RNA polymerase, mitochondrial |
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 Recombinant human DNA polymerase delta subunit 2 |
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| P2733 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA polymerase delta subunit 2 |
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 Recombinant human DNA polymerase subunit gamma-1 |
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| P2838 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA polymerase subunit gamma-1 |
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 DiscoveryProbe? DNA Damage/DNA Repair Library |
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| L1033-.1 | ApexBio | 100 uL/well(10 mM solution) | EUR 3889 |
DiscoveryProbe? DNA Damage/DNA Repair Library |
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| L1033-.25 | ApexBio | 250 uL/well(10 mM solution) | EUR 6905 |
DiscoveryProbe? DNA Damage/DNA Repair Library |
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| L1033-5 | ApexBio | 5 mg/well | EUR 9005 |
 Rat DNA Methyltransferase 1 ELISA kit |
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| E02D0320-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA Methyltransferase 1 ELISA kit |
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| E02D0320-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA Methyltransferase 1 ELISA kit |
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| E02D0320-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Rat DNA Methyltransferase 3A ELISA kit |
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| E02D0321-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA Methyltransferase 3A ELISA kit |
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| E02D0321-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA Methyltransferase 3A ELISA kit |
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| E02D0321-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Rat DNA Methyltransferase 3beta ELISA kit |
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| E02D0322-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3beta in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA Methyltransferase 3beta ELISA kit |
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| E02D0322-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3beta in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA Methyltransferase 3beta ELISA kit |
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| E02D0322-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA Methyltransferase 3beta in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 ELISA kit) Rat DNA (Double Stranded) ELISA kit |
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| E02A0440-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA (Double Stranded) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA (Double Stranded) ELISA kit |
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| E02A0440-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA (Double Stranded) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat DNA (Double Stranded) ELISA kit |
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| E02A0440-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A competitive ELISA for quantitative measurement of Rat DNA (Double Stranded) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Rat Uracil DNA Glycosylase ELISA kit |
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| E02U0076-192T | BlueGene | 192 tests | EUR 1270 |
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Description: A sandwich ELISA for quantitative measurement of Rat Uracil DNA Glycosylase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Uracil DNA Glycosylase ELISA kit |
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| E02U0076-48 | BlueGene | 1 plate of 48 wells | EUR 520 |
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Description: A sandwich ELISA for quantitative measurement of Rat Uracil DNA Glycosylase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat Uracil DNA Glycosylase ELISA kit |
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| E02U0076-96 | BlueGene | 1 plate of 96 wells | EUR 685 |
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Description: A sandwich ELISA for quantitative measurement of Rat Uracil DNA Glycosylase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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 Rat N-DNA-AB ELISA Kit |
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| ERN0082 | Abclonal | 96Tests | EUR 521 |
ELISA Kit) Rat DNA methyltransferase(DNAM)ELISA Kit |
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| GA-E0805RT-48T | GenAsia Biotech | 48T | EUR 317 |
Rat DNA methyltransferase(DNAM)ELISA Kit |
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| GA-E0805RT-96T | GenAsia Biotech | 96T | EUR 496 |
ELISA Kit) Rat DNA methyltransferase3α(DNAM3α)ELISA Kit |
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| GA-E0807RT-48T | GenAsia Biotech | 48T | EUR 317 |
Rat DNA methyltransferase3α(DNAM3α)ELISA Kit |
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| GA-E0807RT-96T | GenAsia Biotech | 96T | EUR 496 |
 Rat Mitochondrial DNA Copy Number Kit |
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| MCN2 | Detroit R&D | 1 Kit | EUR 349 |
Rat DNA methyltransferase3α(DNAM3α)ELISA Kit |
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| QY-E10845 | Qayee Biotechnology | 96T | EUR 361 |
Rat DNA methyltransferase(DNAM)ELISA Kit |
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| QY-E10847 | Qayee Biotechnology | 96T | EUR 361 |
 DNA pol |
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| ABF9055 | Lifescience Market | 100 ug | EUR 438 |
 DNA Polymerase |
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| ABD3082 | Lifescience Market | 100 ug | EUR 438 |
DNA Polymerase |
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| ABF5235 | Lifescience Market | 100 ug | EUR 438 |
 DNA antibody |
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| 10R-D114b | Fitzgerald | 100 ug | EUR 560 |
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Description: Mouse monoclonal DNA antibody |
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DNA antibody |
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| 10C-CR6034M1 | Fitzgerald | 100 ug | EUR 241 |
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Description: Mouse monoclonal DNA antibody |
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DNA antibody |
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| 10-D20A | Fitzgerald | 500 ug | EUR 493 |
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Description: Mouse monoclonal DNA antibody |
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 pUC18 DNA |
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| G40-300 | GeneOn | 50µg | EUR 56 |
pUC18 DNA |
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| G40-305 | GeneOn | 5x50µg | EUR 147 |
 pBR322 DNA |
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| MSD14 | Bio Basic | 50ug | EUR 152.66 |
 DNA-fectamine |
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| DNAF001 | Bio Basic | 1ml | EUR 278.81 |
 T7 DNA |
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| 310-005 | GeneOn | 200µg | EUR 82 |
T7 DNA |
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| 310-025 | GeneOn | 5x200 µg | EUR 225 |
 DNA Antibody |
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| abx023805-02mg | Abbexa | 0.2 mg | EUR 648 |
 DNA-Fect |
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| DF37100-1 | Neuromics | 1 ml | EUR 349 |
 DNA-Fect293 |
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| DF37293-1 | Neuromics | 1 ml | EUR 291 |
 Rat Real-time PCR DNA Quantitation after QPCR DNA Damage Analysis Kit |
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| DD2R | Detroit R&D | 1 Kit | EUR 430 |
 ELISA Kit) Mouse Anti-DNA Antibody (DNA) ELISA Kit |
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| abx257816-96tests | Abbexa | 96 tests | EUR 746 |
 Antibody) DNA Ligase I (DNA Ligase I) Antibody |
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| abx232431-100ug | Abbexa | 100 ug | EUR 481 |
 , DNA Aptamer, Biotinylated) Taq DNA polymerase (TQ21) , DNA Aptamer, Biotinylated |
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| AD-146-B | Alpha Diagnostics | Custom | Ask for price |
 , DNA Aptamer, unlabeled) Taq DNA polymerase (TQ21) , DNA Aptamer, unlabeled |
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| AD-146-U | Alpha Diagnostics | Custom | Ask for price |
, human recombinant) DNA Binding Protein-7 (DBP-7), human recombinant |
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| 7603-100 | Biovision | EUR 588 | |
DNA Binding Protein-7 (DBP-7), human recombinant |
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| 7603-1000 | Biovision | EUR 3258 | |
DNA Binding Protein-7 (DBP-7), human recombinant |
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| 7603-20 | Biovision | EUR 245 | |
) Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) |
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| 4-RPA317Hu01 | Cloud-Clone |
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|
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Description: Recombinant Human Chromodomain Helicase DNA Binding Protein 3 expressed in: E.coli |
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Recombinant Chromodomain Helicase DNA Binding Protein 3 (CHD3) |
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| 4-RPA317Mu01 | Cloud-Clone |
|
|
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Description: Recombinant Mouse Chromodomain Helicase DNA Binding Protein 3 expressed in: E.coli |
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) Recombinant Damage Specific DNA Binding Protein 2 (DDB2) |
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| 4-RPA319Hu01 | Cloud-Clone |
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|
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Description: Recombinant Human Damage Specific DNA Binding Protein 2 expressed in: E.coli |
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Recombinant Damage Specific DNA Binding Protein 2 (DDB2) |
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| 4-RPA319Mu01 | Cloud-Clone |
|
|
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Description: Recombinant Mouse Damage Specific DNA Binding Protein 2 expressed in: E.coli |
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) Recombinant Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) |
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| 4-RPK362Mu01 | Cloud-Clone |
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|
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Description: Recombinant Mouse Protein Kinase, DNA Activated, Catalytic Polypeptide expressed in: E.coli |
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Haplogroup evaluation means that mtDNA haplogroup H2a2a1 has potential contribution within the pathobiology of HAPE in lowlanders. This research suggests contribution of altered mitochondrial features in HAPE susceptibility.
