Mitochondrial genome stability in human: understanding the role of DNA repair pathways
Mitochondria are semiautonomous organelles in eukaryotic cells and possess their very own genome that replicates independently. Mitochondria play a significant function in oxidative phosphorylation on account of which its genome is often uncovered to oxidative stress. Components together with ionizing radiation, radiomimetic medication and replication fork stalling also can lead to several types of mutations in mitochondrial DNA (mtDNA) resulting in genome fragility.
Mitochondria from myopathies, dystonia, most cancers affected person samples present frequent mtDNA mutations reminiscent of level mutations, insertions and large-scale deletions that would account for mitochondria-associated illness pathogenesis. The mechanism by which such mutations come up following publicity to numerous DNA-damaging brokers isn’t nicely understood. One of many well-studied restore pathways in mitochondria is base excision restore.
Different restore pathways reminiscent of mismatch restore, homologous recombination and microhomology-mediated finish becoming a member of have additionally been reported. Curiously, nucleotide excision restore and classical nonhomologous DNA finish becoming a member of should not detected in mitochondria. On this assessment, we summarize the potential causes of mitochondrial genome fragility, their implications in addition to numerous DNA restore pathways that function in mitochondria.
Lack of Mitochondrial Protease CLPP Prompts Sort I IFN Responses via the Mitochondrial DNA-cGAS-STING Signaling Axis
Caseinolytic mitochondrial matrix peptidase proteolytic subunit (CLPP) is a serine protease that degrades broken or misfolded mitochondrial proteins. CLPP-null mice exhibit progress retardation, deafness, and sterility, resembling human Perrault syndrome, but additionally show immune system alterations. Nevertheless, the molecular mechanisms and signaling pathways underlying immunological modifications in CLPP-null mice stay unclear.
On this research, we report the steady-state activation of sort I IFN signaling and antiviral gene expression in CLPP-deficient cells and tissues, leading to marked resistance to RNA and DNA virus an infection. Depletion of the cyclic GMP-AMP (cGAS)-stimulator of IFN genes (STING) DNA sensing pathway reduces steady-state IFN-I signaling and abrogates the broad antiviral phenotype of CLPP-null cells. Furthermore, we report that CLPP deficiency results in mitochondrial DNA (mtDNA) instability and packaging alterations.
Pharmacological and genetic approaches to deplete mtDNA or inhibit cytosolic launch markedly scale back antiviral gene expression, implicating mtDNA stress as the driving force of IFN-I signaling in CLPP-null mice. Our work locations the cGAS-STING-IFN-I innate immune pathway downstream of CLPP and should have implications for understanding Perrault syndrome and different human ailments involving CLPP dysregulation.
Mitochondrial DNA from osteoarthritic sufferers drives purposeful impairment of mitochondrial exercise: a research on transmitochondrial cybrids
With the redefinition of osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now thought of a systemic sickness with a low grade of power irritation. Mitochondrial dysfunction is nicely documented in OA and has the capability to change chondrocyte and synoviocyte perform. Transmitochondrial cybrids are steered as a helpful mobile mannequin to review mitochondrial biology in vitro, as they carry totally different mitochondrial variants with the identical nuclear background.
The purpose of this work was to review mitochondrial and metabolic perform of cybrids with mitochondrial DNA from wholesome (N) and OA donors. On this work, the authors exhibit that cybrids from OA sufferers behave otherwise from cybrids from N donors in a number of mitochondrial parameters. Moreover, OA cybrids behave equally to OA chondrocytes. These outcomes improve our understanding of the function of mitochondria within the degeneration strategy of OA and current cybrids as a helpful mannequin to review OA pathogenesis.
Mitochondrial DNA permits AIM2 inflammasome activation and hepatocyte pyroptosis in non-alcoholic fatty liver illness
Nonalcoholic fatty liver illness (NAFLD) is typified by accumulating extra liver triacylglycerol, irritation, and liver dysfunction. This research was aimed to analyze the function of mitochondrial DNA synthesis-induced activation of Absent in melanoma 2 (AIM2) inflammasome and pyroptosis in NAFLD. Mice had been raised on a high-fat food plan for 24 weeks to ascertain NAFLD fashions. F4/80 immunofluorescence was carried out to mirror the inflammatory response within the liver of mice. Western blot, ELISA, and immunofluorescence had been adopted to find out the expression of AIM2 inflammasome-related proteins and components.
EdU immunofluorescence was utilized for the examination of mitochondrial DNA expression and circulation cytometry for cell pyroptosis. Agarose gel electrophoresis was used to detect the integrity of extracted mouse mitochondrial DNA (mtDNA). The degrees of AIM2 inflammasome-related proteins within the liver and the degrees of IL-1β and IL-18 in serum had been elevated in high-fat diet-induced NAFLD mice. AIM2 inflammasome activation and pyroptosis had been triggered, and suppressed activation of AIM2 inflammasome alleviated the irritation and pyroptosis within the liver of NAFLD mice. Mitochondria had been severely broken and mtDNA was synthesized after NAFLD modeling.
Additional, mtDNA therapy may promote palmitate (PA)-induced activation of AIM2 inflammasome and pyroptosis. Furthermore, inhibition of IRF1 gene alleviated PA-induced AIM2 inflammasome activation and pyroptosis. In conclusion, mitochondrial DNA synthesis may allow AIM2 inflammasome activation and induce the hepatocyte pyroptosis, thereby exacerbating NAFLD.
Haplotypes traceability and genetic variability of the breeding inhabitants of pacu (Piaractus mesopotamicus) revealed by mitochondrial DNA
The principle goal of this research was to estimate the genetic range ranges and haplotype traceability in pacu Piaractus mesopotamicus from the breeding program positioned in Brazil by analyses of the mitochondrial DNA management area (mtDNA). Furthermore, broodstocks from eight business fish farms had been used for comparative analysis, 4 from Brazil (Br1-Br4) and 4 from Argentina (Ar1-Ar4). The descriptive outcomes revealed 47 polymorphic websites and 51 mutations, which evidenced 34 haplotypes. Ten haplotypes had been shared amongst fish farms and 24 had been unique.
The nucleotide range (π) ranged from 0.00031 to 0.01462 and haplotype range (Hd) from 0.125 to 0.868. The evaluation of molecular variance (AMOVA) indicated excessive construction current within the analyzed shares (FST = 0.13356 and ФST = 0.52707). The genetic range was excessive in a lot of the business broodstocks, particularly these from Brazil. We noticed seven haplotypes within the genetic breeding inhabitants, of which 4 had been unique and three shared among the many business fish farms.
S. aureus DNA Gyrase |
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| TG2000GSA-3 | TopoGen | 500 units | EUR 859.2 |
S. aureus DNA Gyrase |
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| TG2000GSA-5 | TopoGen | 1000 units | EUR 1262.4 |
Acinetobacter |
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| PVT14723 | Lifescience Market | 2 ug | EUR 843.6 |
Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (50ug Relaxed DNA + 100u Gyrase) |
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| TG2000G-1KIT | TopoGen | 100 assays | EUR 456 |
Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (250ug Relaxed DNA + 500u Gyrase) |
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| TG2000G-3KIT | TopoGen | 500 assays | EUR 1182 |
Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (500ug Relaxed DNA + 1000u Gyrase) |
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| TG2000G-5KIT | TopoGen | 1000 assays | EUR 1934.4 |
Purified E. coli DNA Gyrase and Relaxed DNA Assay Kit (1mg Relaxed DNA + 2000u Gyrase) |
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| TG2000G-7KIT | TopoGen | 2000 assays | EUR 3412.8 |
Purified E. coli DNA Gyrase Drug Screening Kit (50ug Relaxed DNA + 100u Gyrase) |
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| TG2001G-1KIT | TopoGen | 100 assays | EUR 496.8 |
Purified E. coli DNA Gyrase Drug Screening Kit (250ug Relaxed DNA + 500u Gyrase) |
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| TG2001G-3KIT | TopoGen | 500 assays | EUR 1262.4 |
Purified E. coli DNA Gyrase Drug Screening Kit (500ug Relaxed DNA + 1000u Gyrase) |
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| TG2001G-5KIT | TopoGen | 1000 assays | EUR 2203.2 |
Purified E. coli DNA Gyrase Drug Screening Kit (1mg Relaxed DNA + 2000u Gyrase) |
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| TG2001G-7KIT | TopoGen | 2000 assays | EUR 3547.2 |
E. coli DNA gyrase - for 100 assays |
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| TOP2-100EC | ProFoldin | 100 assays | EUR 309.4 |
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Description: This product includes wild-type E. coli gyrase for 100 assays (40 ul of 2000 nM stock solution) |
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P. aeruginosa DNA gyrase - for 100 assays |
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| TOP2-100PA | ProFoldin | 100 assays | EUR 309.4 |
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Description: This product includes 50 ul of 2 uM P. aeruginosa gyrase |
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S. aureus DNA gyrase - for 100 assays |
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| TOP2-100SA | ProFoldin | 100 assays | EUR 309.4 |
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Description: This product includes 43 ul of 7.5 uM S. aureus gyrase. |
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E. coli DNA Topoisomerase II (Gyrase) Assay Kit Plus (E. coli gyrase included) |
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| DSA020KE | ProFoldin | 20 assays | EUR 221.78 |
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Description: This product includes160 ul of 10 x Buffer T2, 84 ul of 10 x relaxed DNA, 6 ul of 1500 x H19 dye, 90 ul of 10 x ATP and 550 ul of 10 x H19 dilution buffer. It is for 20 assays in 96-well plate format. E. coli gyrase is not included. |
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100 BP DNA LADDER, 500UL PER KIT |
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| M-DNA-100BP | CORNING | 1/pk | EUR 87.6 |
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Description: Bioscience Mol Bio; DNA Ladder |
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1 KB DNA LADDER, 500UL PER KIT |
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| M-DNA-1KB | CORNING | 1/pk | EUR 84 |
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Description: Bioscience Mol Bio; DNA Ladder |
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S. aureus Gyrase DNA Supercoiling Assay Plus-100 |
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| DSA100KSE | ProFoldin | 100 assays | EUR 681.29 |
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Description: This product includes 500 ul of 10 x Buffer T2, 410 ul of 10 x relaxed DNA, 22 ul of 1500 x H19 dye, 450 ul of 10 x ATP, 43 ul 7.5 uM S. aureus gyrase, 820 ul of 2 M potassium glutamate and 3000 ul of 10 x H19 dilution buffer. It is for 100 assays in a 96-well plate format. |
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POLA2 Antibody / DNA polymerase alpha subunit B |
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| RQ6788 | NSJ Bioreagents | 100ug | EUR 419 |
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Description: DNA polymerase alpha subunit 2/B is an enzyme that in humans is encoded by the POLA2 gene. POLA2 may play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity). |
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metallo-b-lactamase inhibitor, DNA aptamer, Biotinylated |
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| AD-159-B | Alpha Diagnostics | Custom | Ask for price |
DNA Topoisomerase II (Gyrase) Assay Kit (enzyme not included) |
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| DSA020K | ProFoldin | 20 assays | EUR 184.03 |
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Description: This product includes the reaction buffer (T2 Buffer), relaxed plasmid DNA and fluorescence dye H19 for 20 assays of DNA supercoiling reactions a 96-well plate assay format or 40 assays in a 384-well assay format. |
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Multivalent B-cell receptor specific, DNA apatamer, Biotinylated |
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| AD-156-B | Alpha Diagnostics | Custom | Ask for price |
Acinetobacter baumannii PCR kit |
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| PCR-H681-48D | Bioingentech | 50T | EUR 543.6 |
Acinetobacter baumannii PCR kit |
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| PCR-H681-96D | Bioingentech | 100T | EUR 686.4 |
S. aureus Gyrase DNA Supercoiling Assay Kit Plus (enzyme included) |
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| DSA020KSE | ProFoldin | 20 assays | EUR 240.65 |
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Description: This product includes160 ul of 10 x Buffer T2, 84 ul of 10 x relaxed DNA, 6 ul of 1500 x H19 dye, 90 ul of 10 x ATP, 10 ul 7.5 uM S. aureus gyrase, 180 ul of 2 M potassium glutamate and 550 ul of 10 x H19 dilution buffer. It is for 20 assays in a 96-well plate format. |
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P. aeruginosa Gyrase DNA Supercoiling Assay Kit Plus (enzyme included) |
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| DSA100KP | ProFoldin | 100 assays | EUR 590.51 |
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Description: This product includes all the reagents for 100 assays of P. aeruginosa gyrase DNA supercoiling activity. This product includes 600 ul of 10 x Buffer T2, 405 ul of 10 x relaxed DNA, 20 ul of 1500 x H19 dye, 450 ul of 10 x ATP, 3000 ul of 10 x H19 dilution buffer and 50 ul 100 x P. aeruginosa gyrase. |
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Platelet-Derived Growth Factor B-chain (36t), DNA Aptamer, Biotinylated |
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| AD-136-B | Alpha Diagnostics | Custom | Ask for price |
Rat Pola2/ DNA polymerase alpha subunit B ELISA Kit |
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| E0777Ra | Sunlong | 1 Kit | EUR 775.2 |
Human POLA2/ DNA polymerase alpha subunit B ELISA Kit |
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| E1985Hu | Sunlong | 1 Kit | EUR 726 |
ELISA kit for Rat DNA polymerase alpha subunit B |
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| EK3396 | SAB | 96 tests | EUR 663.6 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Rat DNA polymerase alpha subunit B in samples from serum, plasma, tissue homogenates and other biological fluids. |
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Rat Pola2(DNA polymerase alpha subunit B) ELISA Kit |
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| ER0533 | FN Test | 96T | EUR 681.12 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 18.75pg/ml |
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Human DNA polymerase alpha subunit B, POLA2 ELISA KIT |
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| ELI-26200h | Lifescience Market | 96 Tests | EUR 988.8 |
Mouse DNA polymerase alpha subunit B, Pola2 ELISA KIT |
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| ELI-26201m | Lifescience Market | 96 Tests | EUR 1038 |
Bovine DNA polymerase alpha subunit B, POLA2 ELISA KIT |
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| ELI-09178b | Lifescience Market | 96 Tests | EUR 1113.6 |
Acinetobacter baumannii RT PCR kit |
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| RTq-H681-100D | Bioingentech | 100T | EUR 860.4 |
Acinetobacter baumannii RT PCR kit |
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| RTq-H681-150D | Bioingentech | 150T | EUR 969.6 |
Acinetobacter baumannii RT PCR kit |
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| RTq-H681-50D | Bioingentech | 50T | EUR 717.6 |
Gyrase Assay Buffer 5x |
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| TG4030 | TopoGen | 1ml | EUR 174 |
Taq DNA polymerase (TQ21) , DNA Aptamer, Biotinylated |
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| AD-146-B | Alpha Diagnostics | Custom | Ask for price |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04978 | CHI Scientific | 5µg | Ask for price |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04979 | CHI Scientific | 25µg | Ask for price |
Recombinant Human DNA Fragmentation Factor Subunit Alpha |
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| 7-04980 | CHI Scientific | 1mg | Ask for price |
DNA Polymerase Delta Subunit 2 Recombinant Protein |
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| 92-121 | ProSci | 0.05 mg | EUR 852.9 |
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Description: DNA Polymerase Delta Subunit 2 (POLD2) belongs to the DNA polymerase delta/II small subunit family. POLD2 can form a heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. POLD2 possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. POLD2 is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). |
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Recombinant human DNA polymerase delta subunit 2 |
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| P2733 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA polymerase delta subunit 2 |
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Recombinant human DNA polymerase subunit gamma-1 |
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| P2838 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA polymerase subunit gamma-1 |
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Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa) |
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| 4-RPL426Hu01 | Cloud-Clone |
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Description: Recombinant Human DNA Fragmentation Factor Subunit Alpha expressed in: E.coli |
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Recombinant DNA Fragmentation Factor Subunit Alpha (DFFa) |
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| 4-RPL426Mu01 | Cloud-Clone |
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Description: Recombinant Mouse DNA Fragmentation Factor Subunit Alpha expressed in: E.coli |
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E. coli DNA Topoisomerase II (Gyrase) Assay Kit Plus-100 (enzyme included) |
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| DSA100KE | ProFoldin | 100 assays | EUR 590.51 |
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Description: This product includes all the reagents for 100 assays of E. coli gyrase DNA supercoiling activity. This product includes 600 ul of 10 x Buffer T2, 405 ul of 10 x relaxed DNA, 20 ul of 1500 x H19 dye, 450 ul of 10 x ATP, 3000 ul of 10 x H19 dilution buffer and 50 ul 100 x E.coli gyrase. |
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96-well E. coli Gyrase DNA Cleavage Assay Kit Plus (enzyme included) |
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| T2C96KE | ProFoldin | 96 assays | EUR 597.7 |
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Description: This product includes 300 ul of 10 x reaction buffer, 30 ul of 10 x DNA, 260 ul of SDS solution, 30 ul of 100 mM ATP, 260 ul of proteinase K solutions, 10 ml of TDC matrix, 6 ml of rinse buffer, 500 ul of 10 x dye, a black receiver plate, a V-bottom reaction plate, 26 ul of 100 x E. coli Gyrase and a TDC filter plate. A plate filtration device and a vacuum line are needed for the plate filtration process. |
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96-Well E. coli gyrase DNA Decatenation Assay Kit Plus (enzyme included) |
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| T2DD-96KE | ProFoldin | 96 assays | EUR 591.41 |
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Description: This product includes the assay buffer, concatenated DNA, E. coli gyrase, ATP, fluorescence dye, rinse buffer and a TDD filter plate for 96 assays of E. coli gyrase DNA decatenation reactions. |
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96-Well S. aureus gyrase DNA Decatenation Assay Kit Plus (enzyme included) |
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| T2DD-96KS | ProFoldin | 96 assays | EUR 681.29 |
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Description: This product includes 600 ul of 10 x assay buffer, 500 ul of 10 x concatenated DNA, 120 ul of 10 mM ATP, 100 ul of 50 x S. aureus gyrase, 600 ul of Stop solution (0.4 M EDTA), 500 ul of 10 x fluorescence dye, 2 ml of 10 x rinse buffer, one V-bottom plate, a TDD filter plate and one black 96-well plates for 96 assays of DNA decatenation reactions. |
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Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.0250 | Bachem | 250.0mg | EUR 166.8 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.1000 | Bachem | 1.0g | EUR 428.4 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Fmoc-b,b-diphenyl-Ala-OH |
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| B-2725.5000 | Bachem | 5.0g | EUR 1603.2 |
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Description: Sum Formula: C30H25NO4; CAS# [201484-50-6] |
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Acinetobacter baumannii Beta-lactamase (NDM-1) |
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| 1-CSB-RP076174Ba | Cusabio |
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Description: Recombinant Acinetobacter baumannii Beta-lactamase(NDM-1),partial expressed in E.coli |
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Acinetobacter baumannii Elongation factor Tu (tuf1) |
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| 1-CSB-YP025342AUD | Cusabio |
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Description: Recombinant Acinetobacter baumannii Elongation factor Tu(tuf1) expressed in Yeast |
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Acinetobacter baumannii Elongation factor Tu (tuf1) |
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| 1-CSB-EP025342AUD | Cusabio |
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Description: Recombinant Acinetobacter baumannii Elongation factor Tu(tuf1) expressed in E.coli |
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Acinetobacter calcoaceticus Catechol 1, 2-dioxygenase |
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| 1-CSB-EP306913AWR | Cusabio |
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Description: Recombinant Acinetobacter calcoaceticus Catechol 1,2-dioxygenase expressed in E.coli |
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Acinetobacter baumannii One-Step PCR kit |
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| Oneq-H681-100D | Bioingentech | 100T | EUR 1039.2 |
Acinetobacter baumannii One-Step PCR kit |
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| Oneq-H681-150D | Bioingentech | 150T | EUR 1177.2 |
Acinetobacter baumannii One-Step PCR kit |
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| Oneq-H681-50D | Bioingentech | 50T | EUR 861.6 |
Human Neutrophil Elastase (DNA I) , DNA Aptamer, Biotinylated |
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| AD-155-B | Alpha Diagnostics | Custom | Ask for price |
5X SA Gyrase Assay Buffer |
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| TG4045 | TopoGen | 1ml | EUR 187.2 |
Pola2 ELISA Kit| Rat DNA polymerase alpha subunit B ELISA Kit |
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| EF017366 | Lifescience Market | 96 Tests | EUR 826.8 |
Analyte Mix B |
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| 507-B | Scientific Laboratory Supplies | 1ML | EUR 182.4 |
Analyte Mix B |
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| 5081-B | Scientific Laboratory Supplies | 1ML | EUR 129.96 |
Phenolics Mix B |
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| 8040-B | Scientific Laboratory Supplies | 1ML | EUR 61.56 |
DNA pol ? B Polyclonal Antibody |
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| ABP52796-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of DNA pol ? B from Human. This DNA pol ? B antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DNA pol ? B |
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DNA pol ? B Polyclonal Antibody |
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| ABP52796-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of DNA pol ? B from Human. This DNA pol ? B antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DNA pol ? B |
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DNA pol ? B Polyclonal Antibody |
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| ABP52796-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of DNA pol ? B from Human. This DNA pol ? B antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human DNA pol ? B |
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DNA pol ? B Polyclonal Antibody |
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| ES3795-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against DNA pol ? B from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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DNA pol ? B Polyclonal Antibody |
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| ES3795-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against DNA pol ? B from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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DNA Helicase B (HELB) Antibody |
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| abx233821-100ug | Abbexa | 100 ug | EUR 661.2 |
Adenosine, DNA Aptamer, Biotinylated |
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| AD-103-B | Alpha Diagnostics | Custom | Ask for price |
Acinetobacter baumannii Outer membrane protein Omp38 (omp38) |
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| 1-CSB-YP387720AUD | Cusabio |
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Description: Recombinant Acinetobacter baumannii Outer membrane protein Omp38(omp38) expressed in Yeast |
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Acinetobacter baylyi Catechol 1, 2-dioxygenase (catA) |
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| 1-CSB-EP357202AWW | Cusabio |
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Description: Recombinant Acinetobacter baylyi Catechol 1,2-dioxygenase(catA) expressed in E.coli |
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Acinetobacter baumannii Outer membrane protein Omp38 (omp38) |
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| 1-CSB-EP387720AUD | Cusabio |
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Description: Recombinant Acinetobacter baumannii Outer membrane protein Omp38(omp38) expressed in E.coli |
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50-1500bp DNA Marker, Ready-to-use |
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| M109-B | Bio Basic | 5x100loading, 500prep | EUR 263.58 |
DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PK) Antibody |
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| 20-abx013061 | Abbexa |
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DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Antibody |
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| 20-abx008825 | Abbexa |
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DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs) Antibody |
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| abx232474-100ug | Abbexa | 100 ug | EUR 610.8 |
Calcineurin Subunit B Type 1 Recombinant Protein |
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| 92-008 | ProSci | 0.05 mg | EUR 821.4 |
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Description: Calcineurin Subunit B Type 1 belongs to the calcineurin regulatory subunit family. Calcineurin Subunit B Type 1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase. It is composed of a catalytic subunit (A) and a regulatory subunit (B). It contains four EF-hand domains and four functional calcium-binding sites. Calcineurin Subunit B Type 1 plays an improtant role in the T cell activation pathway. |
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Recombinant Succinate Dehydrogenase Complex Subunit B (SDHB) |
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| 4-RPJ756Hu01 | Cloud-Clone |
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Description: Recombinant Human Succinate Dehydrogenase Complex Subunit B expressed in: E.coli |
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Recombinant Succinate Dehydrogenase Complex Subunit B (SDHB) |
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| 4-RPJ756Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Succinate Dehydrogenase Complex Subunit B expressed in: E.coli |
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Fmoc-b-Ala-OH |
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| B-1025.0005 | Bachem | 5.0g | EUR 138 |
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Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OH |
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| B-1025.0025 | Bachem | 25.0g | EUR 283.2 |
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Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OH |
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| B-1025.0100 | Bachem | 100.0g | EUR 762 |
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Description: Sum Formula: C18H17NO4; CAS# [35737-10-1] |
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Fmoc-b-Ala-OPfp |
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| B-1765.0005 | Bachem | 5.0g | EUR 283.2 |
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Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8] |
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Fmoc-b-Ala-OPfp |
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| B-1765.0025 | Bachem | 25.0g | EUR 1009.2 |
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Description: Sum Formula: C24H16F5NO4; CAS# [149303-38-8] |
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Purgeable Gases Mix B |
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| 5022-B | Scientific Laboratory Supplies | 1ML | EUR 27.36 |
Purgeable Gases Mix B |
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| 624-B | Scientific Laboratory Supplies | 1ML | EUR 249.66 |
Recombinant DNA-directed RNA polymerase 132 kDa polypeptide(RPO132) ,partial |
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| CSB-EP851803MHV-B | Cusabio | 20μg | Ask for price |
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Description: In Vivo Biotinylation in E.coli |
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Recombinant Intermediate transcription factor 3 large subunit(VITF3L) |
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| CSB-EP823719MHV-B | Cusabio | 20μg | Ask for price |
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Description: In Vivo Biotinylation in E.coli |
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Recombinant human DNA-directed RNA polymerase III subunit RPC4 |
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| P1640 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human DNA-directed RNA polymerase III subunit RPC4 |
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DFFA DNA Fragmentation Factor Subunit Alpha Human Recombinant Protein |
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| PROTO00273 | BosterBio | Regular: 25ug | EUR 380.4 |
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Description: DFFA Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 351 amino acids (1- 331 a.a.) and having a molecular mass of 38.7kDa.;The DFFA is purified by proprietary chromatographic techniques. |
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Bisphenol A, DNA Aptamer, Biotinylated |
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| AD-108-B | Alpha Diagnostics | Custom | Ask for price |
Daunomycin (10.10), DNA Aptamer, Biotinylated |
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| AD-113-B | Alpha Diagnostics | Custom | Ask for price |
Daunomycin (10.10v), DNA Aptamer, Biotinylated |
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| AD-114-B | Alpha Diagnostics | Custom | Ask for price |
Ethanolamine (14.3), DNA Aptamer, Biotinylated |
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| AD-115-B | Alpha Diagnostics | Custom | Ask for price |
Hematoporphyrin IX , DNA Aptamer, Biotinylated |
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| AD-117-B | Alpha Diagnostics | Custom | Ask for price |
Pb(II) , DNA Aptamer, Biotinylated |
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| AD-131-B | Alpha Diagnostics | Custom | Ask for price |
Ramos Cells , DNA Aptamer, Biotinylated |
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| AD-138-B | Alpha Diagnostics | Custom | Ask for price |
Streptavidin (31), DNA Aptamer, Biotinylated |
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| AD-144-B | Alpha Diagnostics | Custom | Ask for price |
Tetracyclines (T24) , DNA Aptamer, Biotinylated |
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| AD-148-B | Alpha Diagnostics | Custom | Ask for price |
Thrombin(15mer) , DNA Aptamer, Biotinylated |
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| AD-150-B | Alpha Diagnostics | Custom | Ask for price |
TLR-9, DNA aptamer, Biotinylated |
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| AD-158-B | Alpha Diagnostics | Custom | Ask for price |
Human DNA primase small subunit (PRIM1) |
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| 1-CSB-EP018680HU | Cusabio |
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Description: Recombinant Human DNA primase small subunit(PRIM1) expressed in E.coli |
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Primase (DNA) Subunit 1 (PRIM1) Antibody |
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| 20-abx014428 | Abbexa |
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Primase (DNA) Subunit 1 (PRIM1) Antibody |
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| 20-abx008837 | Abbexa |
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Primase (DNA) Subunit 1 (PRIM1) Antibody |
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| abx036212-100ug | Abbexa | 100 ug | EUR 469.2 |
DNA Fragmentation Factor Subunit alpha Protein |
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| 20-abx261772 | Abbexa |
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Primase (DNA) Subunit 1 (PRIM1) Antibody |
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| abx332539-100ul | Abbexa | 100 ul | EUR 510 |
Primase (DNA) Subunit 1 (PRIM1) Antibody |
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| 20-abx301005 | Abbexa |
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DNA Polymerase Catalytic Subunit (BALF5) Antibody |
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| 20-abx319917 | Abbexa |
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Primase (DNA) Subunit 1 (PRIM1) Antibody |
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| 20-abx328360 | Abbexa |
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Primase (DNA) Subunit 1 (PRIM1) Antibody |
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| abx236776-100ug | Abbexa | 100 ug | EUR 577.2 |
The genetic range was average (π = 0.00265 and Hd = 0.424) and regarded appropriated for this breeding inhabitants of pacu. Our outcomes present help for the genetic range upkeep and mtDNA traceability of pacu business broodstocks.
